Abstract: This invention relates to novel compounds according to Formula (I) which are antagonists of MrgX2, to pharmaceutical compositions containing them, and to their use in therapy for the treatment of MrgX2-mediated diseases and disorders.

Abstract: An imaging system for generating an image of a region of an eye, comprising: an ocular imaging device controlled by a control module to acquire, from a first viewpoint, a first ocular image of the region having an image artefact caused by obstruction from imaging of a part of the region by an object, and a second ocular image from a predetermined second viewpoint, which shows at least a portion of the part of the region that was obstructed from imaging during acquisition of the first ocular image; and an image data processing module for combining the first and second ocular images to generate an enhanced ocular image having an image artefact caused by obstruction from imaging by the object which is smaller in relation to the image artefact in the first or second ocular image, or no such image artefact.

Abstract: An ophthalmic scanning system includes a first imaging modality, a second imaging modality different from the first imaging modality, and a control system that maps the first imaging modality to the second imaging modality by compensating for at least one of an optical-mechanical and an electro-mechanical projection difference between the first and second imaging modalities. The control system provides a scan location for the second imaging modality based on a scan location of the first imaging modality.

Abstract: An in vitro method for identifying, isolating and/or enriching primate naive pluripotent stem cells, the method including analyzing transcription of a type 7 long terminal repeat (LTR7) nucleic acid sequence of a type H human endogenous retrovirus (HERVH) (LTR7/HERVH-associated transcription), and identifying, isolating and/or enriching primate naive pluripotent stem cells based on LTR7/HERVH-associated transcription, wherein LTR7/HERVH-associated transcription is a marker for primate naive pluripotent stem cells. An isolated in vitro population of primate naive pluripotent stem cells is obtained by the method, wherein in the cells LTR7/HERVH-associated transcription is elevated in comparison to control cells, wherein control cells are primed pluripotent stem cells or differentiated cells.

Abstract: An ophthalmic scanning system includes a first imaging modality, a second imaging modality different from the first imaging modality, and a control system that maps the first imaging modality to the second imaging modality by compensating for at least one of an optical-mechanical and an electro-mechanical projection difference between the first and second imaging modalities. The control system provides a scan location for the second imaging modality based on a scan location of the first imaging modality.

Abstract: An imaging system for generating an image of a region of an eye, comprising: an ocular imaging device controlled by a control module to acquire, from a first viewpoint, a first ocular image of the region having an image artefact caused by obstruction from imaging of a part of the region by an object, and a second ocular image from a predetermined second viewpoint, which shows at least a portion of the part of the region that was obstructed from imaging during acquisition of the first ocular image; and an image data processing module for combining the first and second ocular images to generate an enhanced ocular image having an image artefact caused by obstruction from imaging by the object which is smaller in relation to the image artefact in the first or second ocular image, or no such image artefact.

Abstract: A method of generating a look-up table, LUT, for constructing a dewarped B-scan image from A-scans of a cropped part of a sequence of acquired OCT A-scans, the LUT associating each of a plurality of pixel arrays that are to form the dewarped B-scan image with a respective A-scan in the cropped part. The method comprises: using an indication of a spatial distribution of scan locations of A-scans to determine a dewarp function for selecting, from among acquired A-scans, A-scans having uniformly spaced scan locations; using the function and cropping information, in accordance with which the cropped part is cropped from the acquired sequence, to select, for each array, a respective A-scan from the sequence such that A-scans are selected from the cropped part and have uniformly spaced scan locations; and storing, for each array, a respective pixel array identifier in association with a respective identifier of the selected A-scan.

Abstract: A method of generating a look-up table, LUT, for constructing a dewarped B-scan image from A-scans of a cropped part of a sequence of acquired OCT A-scans, the LUT associating each of a plurality of pixel arrays that are to form the dewarped B-scan image with a respective A-scan in the cropped part. The method comprises: using an indication of a spatial distribution of scan locations of A-scans to determine a dewarp function for selecting, from among acquired A-scans, A-scans having uniformly spaced scan locations; using the function and cropping information, in accordance with which the cropped part is cropped from the acquired sequence, to select, for each array, a respective A-scan from the sequence such that A-scans are selected from the cropped part and have uniformly spaced scan locations; and storing, for each array, a respective pixel array identifier in association with a respective identifier of the selected A-scan.

Abstract: An in vitro method for identifying, isolating and/or enriching primate naive pluripotent stem cells, the method including analyzing transcription of a type 7 long terminal repeat (LTR7) nucleic acid sequence of a type H human endogenous retrovirus (HERVH) (LTR7/HERVH-associated transcription), and identifying, isolating and/or enriching primate naive pluripotent stem cells based on LTR7/HERVH-associated transcription, wherein LTR7/HERVH-associated transcription is a marker for primate naive pluripotent stem cells. An isolated in vitro population of primate naive pluripotent stem cells is obtained by the method, wherein in the cells LTR7/HERVH-associated transcription is elevated in comparison to control cells, wherein control cells are primed pluripotent stem cells or differentiated cells.

Abstract: A seal assembly is for a spherical plain bearing with an inner ring mounted on a shaft and an outer ring disposed about the inner ring and having a concave inner surface slidably displaceable against the inner ring convex outer surface. The seal assembly includes an annular inner member disposed about the shaft axially adjacent to the bearing inner ring and having opposing first and second axial ends and an outer engagement surface extending axially between the first and second ends. A generally annular outer member has a base portion coupled with the bearing outer ring and a lip portion extending radially inwardly from the base portion and having an outer end sealingly engageable with the outer engagement surface of the seal inner member. The lip portion slidably displaces generally axially along the inner member engagement surface when the outer ring displaces axially relative to the inner ring.

Abstract: One or more type 7 long terminal repeat (LTR7) nucleic acid sequences of type H human endogenous retroviruses (HERVH) (“LTR7/HERVH nucleic acid sequences”) can be used for identifying primate naïve pluripotent stem cells. LTR7/HERVH-associated transcription can be used as a marker for primate naive pluripotent stem cells. A reporter construct that includes LTR7/HERVH nucleic acid sequences can be used for optimizing culture conditions for naïve primate pluripotent stem cells. A cell growth medium can be used for cultivation of primate naive pluripotent stem cells, which can exhibit elevated levels of LTR7/HERVH-associated transcription in comparison to control cells.