Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a catheter shaft. An expandable member may be coupled to the catheter shaft. The expandable member may be capable of shifting between a folded configuration and an expanded configuration. A plurality of flexible elements may be attached to the expandable member, with a plurality of electrode assemblies disposed on the flexible elements. The flexible elements may have a grooved substrate.

Abstract: A medical device for sympathetic nerve ablation may include a catheter shaft, an expandable member disposed on or coupled to the catheter shaft, and a plurality of elongate electrode assemblies each constructed as a flexible circuit having a plurality of layers. The expandable member may be configured to shift between an unexpanded configuration and an expanded configuration. The plurality of electrode assemblies may be disposed on an outer surface of the expandable member. Each of the plurality of electrode assemblies may include enhanced tear resistance properties such as through the inclusion of a reinforcement structure with one or more of the layers of the electrode assemblies.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a catheter shaft. An expandable balloon may be coupled to the catheter shaft. The balloon may be capable of shifting between a folded configuration and an expanded configuration. A support structure may be coupled to the balloon. The support structure may be capable of shifting the balloon toward the folded configuration. A plurality of elongate flexible electrode assemblies may be disposed on the balloon. The elongate flexible electrode assemblies may be oriented at an angle relative to a longitudinal axis of the balloon.

Abstract: Medical devices and methods for making and using the same are disclosed. An example medical device may include a medical device for tissue ablation. The medical device may include an elongated shaft having a distal region. An inflatable balloon may be mounted to the distal region. The inflatable balloon may include a body region, a proximal waist, a distal waist, a proximal cone region, and a distal cone region. A skirt may be attached to the inflatable balloon and may extend proximally from the body region. An electrode assembly may be applied directly to an outer surface of the body region of the inflatable balloon. The electrode assembly may include a first conductive member applied directly to the outer surface of the body region of the inflatable balloon and extending proximally therefrom along an outer surface of the skirt.

Abstract: The disclosure pertains to an intravascular catheter, comprising an elongate member having a proximal end and a distal end, a balloon having an interior surface, an exterior surface, a lumen defined by the interior surface and a cylindrical wall extending between the interior surface and the exterior surface, the cylindrical wall having a proximal end and a distal end, the balloon having a plurality of weeping windows disposed in the wall and able to pass an electric current between the interior surface and the exterior surface and wherein the balloon wall is otherwise electrically insulative, and an electrode disposed in the balloon. The intravascular system is suited for modulation of renal nerves, for example.

Abstract: An expandable medical balloon including an inner layer formed of a poly (ether-block-amide) copolymer and an outer layer formed of a polyamide, the expandable medical balloon having a burst strength of greater than 50,000 psi, and to methods of making and using the same.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a catheter shaft. An expandable member may be coupled to the catheter shaft. The expandable member may be capable of shifting between a folded configuration and an expanded configuration. A plurality of flexible elements may be attached to the expandable member, with a plurality of electrode assemblies disposed on the flexible elements. The flexible elements may have a grooved substrate.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a catheter shaft. An expandable member may be coupled to the catheter shaft. The expandable member may be capable of shifting between a folded configuration and an expanded configuration. A plurality of flexible elements may be attached to the expandable member, with a plurality of electrode assemblies disposed on the flexible elements. The flexible elements may have a grooved substrate.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a medical device for modulating nerves. The medical device may include an elongate shaft having a distal region. A balloon may be coupled to the distal region. An electrode may be disposed within the balloon. A virtual electrode may be defined on the balloon. The virtual electrode may include a conductive region having an edge and a peripheral region disposed at least partially along the edge of the conductive region. The peripheral region may be configured to dissipate forces, electrical current, or both accumulating along the edge of the conductive region.

Abstract: The disclosure pertains to an intravascular catheter for nerve modulation, comprising an elongate member having a proximal end and a distal end, a balloon having a lumen and a balloon wall, the balloon wall comprising RF permeable sections and non-electrically conductive sections, an electrode disposed within the balloon and extending distally to the furthest distal RF permeable section. The RF permeable sections may comprise a plurality of RF permeable windows, each window having a greater circumferential dimension than an axial dimension. The intravascular system is suited for modulation of renal nerves.

Abstract: An expandable medical balloon for transmitting radiofrequency energy, the medical balloon comprising at least one polymeric electrically-insulating layer and at least one polymeric electrically-conductive layer, wherein at least portions of the polymeric electrically-insulating layer are moveable relative to the polymeric electrically-conductive in said at least one pressurizable expanded state.

Abstract: The disclosure pertains to an intravascular catheter for nerve modulation, comprising an elongate member having a proximal end and a distal end, a balloon having a lumen and a balloon wall, the balloon wall comprising RF permeable sections and non-electrically conductive sections, an electrode disposed within the balloon and extending distally to the furthest distal RF permeable section. The RF permeable sections may comprise a plurality of RF permeable windows, each window having a greater circumferential dimension than an axial dimension. The intravascular system is suited for modulation of renal nerves.

Abstract: The present invention provides medical devices comprising nanocomposite materials. By utilizing nanocomposites in the production thereof, the inventive medical devices can be produced with various advantageous properties. Methods of producing the inventive medical devices are also provided. Inasmuch as the inventive devices are expected to provide certain advantages in their use, there is also provided a method of medical care including methods of treatment or diagnosis, wherein the inventive devices are brought into therapeutic contact with a body to be treated or diagnosed thereby.

Abstract: The disclosure pertains to an intravascular catheter for nerve modulation, comprising an elongate member having a proximal end and a distal end, a balloon having a lumen and a balloon wall, the balloon wall comprising RF permeable sections and non-electrically conductive sections, an electrode disposed within the balloon and extending distally to the furthest distal RF permeable section. The RF permeable sections may comprise a plurality of RF permeable windows, each window having a greater circumferential dimension than an axial dimension. The intravascular system is suited for modulation of renal nerves.

Abstract: Medical devices and methods for forming the medical devices are disclosed in the present application. In one illustrative example, a medical device may comprise a catheter shaft extending from a proximal end to a distal end and may include a plurality of lumens extending through at least a portion of the catheter shaft. In some examples, the medical device may further include a balloon member disposed proximate the distal end of the catheter shaft, and the catheter shaft may comprise a frangible portion disposed proximate the distal end of the catheter shaft.

Abstract: Described is a guide catheter for guiding other medical devices into or through a body lumen, comprising: a polymeric, tubular inner liner having a textured inner surface; and, a polymeric jacket bonded to an exterior of the inner liner; wherein the texture of the inner surface of the inner liner reduces the coefficient of friction between the inner liner and the other medical devices.

Abstract: An expandable medical balloon including an inner layer formed of a poly(ether-block-amide) copolymer and an outer layer formed of a polyamide, the expandable medical balloon having a burst strength of greater than 50,000 psi, and to methods of making and using the same.

Abstract: A medical device for sympathetic nerve ablation may include a catheter shaft, an expandable member disposed on or coupled to the catheter shaft, and a plurality of elongate electrode assemblies each constructed as a flexible circuit having a plurality of layers. The expandable member may be configured to shift between an unexpanded configuration and an expanded configuration. The plurality of electrode assemblies may be disposed on an outer surface of the expandable member. Each of the plurality of electrode assemblies may include enhanced tear resistance properties such as through the inclusion of a reinforcement structure with one or more of the layers of the electrode assemblies.

Abstract: An expandable medical balloon comprising an inner layer formed of a polymer material having a first flexural modulus, an intermediate layer formed of a material having a second flexural and an outer layer formed of a material having a third flexural modulus, wherein the flexural modulus of the inner layer and outer layer is 50,000 psi to about 80,000 psi, the flexural modulus of the intermediate layer is about 130,000 to about 230,000 psi and the calculated burst strength of the balloon determined on a 90 degree bend in the balloon is about 35,000 psi or higher.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a catheter shaft. An expandable member may be coupled to the catheter shaft. The expandable member may be capable of shifting between a folded configuration and an expanded configuration. A plurality of flexible elements may be attached to the expandable member, with a plurality of electrode assemblies disposed on the flexible elements. The flexible elements may have a grooved substrate.