Patents by Inventor Daniel James Ford

Daniel James Ford has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrimidinone derivatives as CDC7 inhibitors
    Patent number: 11766434
    Abstract: The present invention relates to compounds of formula I as defined herein, and salts and solvates thereof, that function as inhibitors of cell division cycle 7 (Cdc7) kinase enzyme activity. The present invention also relates to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which Cdc7 kinase activity is implicated.
    Type: Grant
    Filed: April 29, 2021
    Date of Patent: September 26, 2023
    Assignee: Cancer Research Technology Limited
    Inventors: Emma L. Carswell, Mark David Charles, Chukuemeka Tennyson Ekwuru, Frederic Elustondo, Katherine M. Fowler, Gregory R. Ott, Jonathan R. Roffey, Joanna L. Brookfield, Daniel James Ford, Mathew L. Calder
  • PYRIMIDINONE DERIVATIVES AS CDC7 INHIBITORS
    Publication number: 20220079942
    Abstract: The present invention relates to compounds of formula I as defined herein, and salts and solvates thereof, that function as inhibitors of cell division cycle 7 (Cdc7) kinase enzyme activity. The present invention also relates to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which Cdc7 kinase activity is implicated.
    Type: Application
    Filed: April 29, 2021
    Publication date: March 17, 2022
    Inventors: Emma L. Carswell, Mark David Charles, Chukuemeka Tennyson Ekwuru, Frederic Elustondo, Katherine M. Fowler, Gregory R. Ott, Jonathan R. Roffey, Joanna L. Brookfield, Daniel James Ford, Mathew L. Calder
  • Pyrimidinone derivatives as Cdc7 inhibitors
    Patent number: 11020396
    Abstract: The present invention relates to compounds of formula I as defined herein, and salts and solvates thereof, that function as inhibitors of cell division cycle 7 (Cdc7) kinase enzyme activity. The present invention also relates to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which Cdc7 kinase activity is implicated.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: June 1, 2021
    Assignee: Cancer Research Technology Limited
    Inventors: Emma L. Carswell, Mark David Charles, Chukuemeka Tennyson Ekwuru, Frederic Elustondo, Katherine M. Fowler, Gregory R. Ott, Jonathan R. Roffey, Joanna L. Brookfield, Daniel James Ford, Mathew L. Calder
  • PYRIMIDINONE DERIVATIVES AS CDC7 INHIBITORS
    Publication number: 20190336502
    Abstract: The present invention relates to compounds of formula I as defined herein, and salts and solvates thereof, that function as inhibitors of cell division cycle 7 (Cdc7) kinase enzyme activity. The present invention also relates to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which Cdc7 kinase activity is implicated.
    Type: Application
    Filed: November 7, 2017
    Publication date: November 7, 2019
    Inventors: Emma L. Carswell, Mark David Charles, Chukuemeka Tennyson Ekwuru, Frederic Elustondo, Katherine M. Fowler, Gregory R. Ott, Jonathan R. Roffey, Joanna L. Brookfield, Daniel James Ford, Mathew L. Calder
  • Fused Pyrazole Derivatives As Kinase Inhibitors
    Publication number: 20180298009
    Abstract: A series of substituted pyrazolo[1,5-a]pyrimidine and pyrazolo[1,5-a][1,3,5]-triazine derivatives of formula (I), as defined herein, being selective inhibitors of phosphatidylinositol-4-kinase III? (PI4KIII?) activity, are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases and malaria; and organ and cell transplant rejection.
    Type: Application
    Filed: September 28, 2016
    Publication date: October 18, 2018
    Inventors: Daniel James Ford, Helen Tracey Horsley, James Thomas Reuberson
  • Pyrazolo-pyridine derivatives as kinase inhibitors
    Patent number: 10087180
    Abstract: A series of pyrazolo[3,4-b]pyridine derivatives that are substituted at the 4-position by a diaza monocyclic, bridged bicyclic or spirocyclic moiety, being selective inhibitors of phosphatidylinositol-4-kinase III? (PI4KIII?) activity, are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases and malaria; and organ and cell transplant rejection.
    Type: Grant
    Filed: June 11, 2015
    Date of Patent: October 2, 2018
    Assignee: UCB BIOPHARMA SPRL
    Inventors: Daniel James Ford, James Thomas Reuberson
  • Fused Bicyclic Heteroaromatic Derivatives as Kinase Inhibitors
    Publication number: 20180201622
    Abstract: A series of fused bicyclic heteroaromatic derivatives of formula (IA) or (IB), as defined herein, being selective inhibitors of phosphatidylinositol-4-kinase III? (PI4KIII?) activity, are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases and malaria; and organ and cell transplant rejection.
    Type: Application
    Filed: March 16, 2018
    Publication date: July 19, 2018
    Inventors: Daniel James Ford, Qiuya Huang, Judi Charlotte Neuss, James Thomas Reuberson, Bart Vanderhoydonck
  • Fused bicyclic heteroaromatic derivatives as kinase inhibitors
    Patent number: 9969748
    Abstract: A series of fused bicyclic heteroaromatic derivatives of formula (IA) or (IB), as defined herein, being selective inhibitors of phosphatidylinositol-4-kinase III? (PI4KIII?) activity, are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases and malaria; and organ and cell transplant rejection.
    Type: Grant
    Filed: June 11, 2015
    Date of Patent: May 15, 2018
    Assignees: UCB Biopharma SPRL, Katholieke Universiteit Leuven, K.U. Leuven R&D
    Inventors: Daniel James Ford, Qiuya Huang, Judi Charlotte Neuss, James Thomas Reuberson, Bart Vanderhoydonck
  • Therapeutically active pyrazolo-pyrimidine derivatives
    Patent number: 9714248
    Abstract: A series of pyrazolo[3,4-d]pyrimidine derivatives that are substituted at the 4-position by a diaza monocyclic, bridged bicyclic or spirocyclic moiety, are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases and malaria; and organ and cell transplant rejection.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: July 25, 2017
    Inventors: Daniel James Ford, Richard Jeremy Franklin, Anant Ramrao Ghawalkar, Helen Tracey Horsley, Qiuya Huang, James Thomas Reuberson, Bart Vanderhoydonck
  • Fused Bicyclic Heteroaromatic Derivatives as Kinase Inhibitors
    Publication number: 20170129905
    Abstract: A series of fused bicyclic heteroaromatic derivatives of formula (IA) or (IB), as defined herein, being selective inhibitors of phosphatidylinositol-4-kinase III? (PI4KIII?) activity, are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases and malaria; and organ and cell transplant rejection.
    Type: Application
    Filed: June 11, 2015
    Publication date: May 11, 2017
    Inventors: Daniel James Ford, Qiuya Huang, Judi Charlotte Neuss, James Thomas Reuberson, Bart Vanderhoydonck
  • Pyrazolo-Pyridine Derivatives as Kinase Inhibitors
    Publication number: 20170121324
    Abstract: A series of pyrazolo[3,4-b]pyridine derivatives that are substituted at the 4-position by a diaza monocyclic, bridged bicyclic or spirocyclic moiety, being selective inhibitors of phosphatidylinositol-4-kinase III? (PI4KIII?) activity, are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases and malaria; and organ and cell transplant rejection.
    Type: Application
    Filed: June 11, 2015
    Publication date: May 4, 2017
    Inventors: Daniel James Ford, James Thomas Reuberson
  • Therapeutically Active Pyrazolo-Pyrimidine Derivatives
    Publication number: 20160194329
    Abstract: A series of pyrazolo[3,4-d]pyrimidine derivatives that are substituted at the 4-position by a diaza monocyclic, bridged bicyclic or spirocyclic moiety, are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases and malaria; and organ and cell transplant rejection.
    Type: Application
    Filed: December 20, 2013
    Publication date: July 7, 2016
    Inventors: Daniel James Ford, Richard Jeremy Franklin, Anant Ramrao Ghawalkar, Helen Tracey Horsley, Qiuya Huang, James Thomas Reuberson, Bart Vanderhoydonck
  • Therapeutically active oxazoline derivatives
    Patent number: 9382263
    Abstract: Compounds of formula (I) i.e. monocyclic or bicyclic diamine-substituted thieno[2,3-d]pyrimidine and isothiazolo[5,4-d]pyrimidine derivatives substituted by an optionally substituted oxazolin-2-yl moiety, are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases; and organ and cell transplant rejection.
    Type: Grant
    Filed: October 2, 2013
    Date of Patent: July 5, 2016
    Assignee: UCB Biopharma SPRL
    Inventors: Claire Louise Kulisa, Daniel Christopher Brookings, Daniel James Ford, Richard Jeremy Franklin, James Thomas Reuberson, Anant Ramrao Ghawalkar
  • Therapeutically active fused pyrimidine derivatives
    Patent number: 9227984
    Abstract: A series of monocyclic or bicyclic diamine-substituted thieno[2,3-d]pyrimidine and isothiazolo[5,4-d]pyrimidine derivatives are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases; and organ and cell transplant rejection.
    Type: Grant
    Filed: August 15, 2012
    Date of Patent: January 5, 2016
    Assignees: UCB Pharma S.A., Katholieke Universiteit Leuven, K.U.Leuven R&D
    Inventors: Daniel Christopher Brookings, Daniel James Ford, Anant Ramrao Ghawalkar, Jean Herman, Qiuya Huang, Claire Louise Kulisa, Thierry Louat, Judi Charlotte Neuss, James Thomas Reuberson, Bart Vanderhoydonck
  • Therapeutically Active Oxazoline Derivatives
    Publication number: 20150274748
    Abstract: Compounds of formula (I) i.e. monocyclic or bicyclic diamine-substituted thieno[2,3-d]pyrimidine and isothiazolo[5,4-d]pyrimidine derivatives substituted by an optionally substituted oxazolin-2-yl moiety, are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases; and organ and cell transplant rejection.
    Type: Application
    Filed: October 2, 2013
    Publication date: October 1, 2015
    Inventors: Claire Louise Kulisa, Daniel Christopher Brookings, Daniel James Ford, Richard Jeremy Franklin, James Thomas Reuberson, Anant Ramrao Ghawalkar
  • Therapeutically active thiazolo-pyrimidine derivatives
    Patent number: 9096614
    Abstract: A series of thiazolo[5,4-d]pyrimidine derivatives of formula (I) or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof: (I) Q represents a group of formula (Qa), (Qb), (Qc), (Qd) or (Qe) are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases; and organ and cell transplant rejection.
    Type: Grant
    Filed: November 8, 2012
    Date of Patent: August 4, 2015
    Inventors: Daniel Christopher Brookings, Daniel James Ford, Richard Jeremy Franklin, Anant Ramrao Ghawalkar, Claire Louise Kulisa, Judi Charlotte Neuss, James Thomas Reuberson
  • Quinoline derivatives as kinase inhibitors
    Patent number: 9029392
    Abstract: Disclosed are a series of quinoline and quinoxaline derivatives comprising a fluorinated ethyl side-chain, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.
    Type: Grant
    Filed: September 2, 2011
    Date of Patent: May 12, 2015
    Assignee: UCB Pharma S.A.
    Inventors: Andrew Harry Parton, Mezher Hussein Ali, Daniel Christopher Brookings, Julien Alistair Brown, Daniel James Ford, Richard Jeremy Franklin, Judi Charlotte Neuss, Joanna Rachel Quincey, Jackalyn Hinkins
  • Therapeutically Active Thiazolo-Pyrimidine Derivatives
    Publication number: 20140315885
    Abstract: A series of thiazolo[5,4-d]pyrimidine derivatives of formula (I) or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof: (I) Q represents a group of formula (Qa), (Qb), (Qc), (Qd) or (Qe) are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases; and organ and cell transplant rejection.
    Type: Application
    Filed: November 8, 2012
    Publication date: October 23, 2014
    Inventors: Daniel Christopher Brookings, Daniel James Ford, Richard Jeremy Franklin, Anant Ramrao Ghawalkar, Claire Louise Kulisa, Judi Charlotte Neuss, James Thomas Reuberson
  • Therapeutically Active Fused Pyrimidine Derivatives
    Publication number: 20140309222
    Abstract: A series of monocyclic or bicyclic diamine-substituted thieno[2,3-d]pyrimidine and isothiazolo[5,4-d]pyrimidine derivatives are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases; and organ and cell transplant rejection.
    Type: Application
    Filed: August 15, 2012
    Publication date: October 16, 2014
    Applicants: KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D, UCB PHARMA S.A.
    Inventors: Daniel Christopher Brookings, Daniel James Ford, Anant Ramrao Ghawalkar, Jean Herman, Qiuya Huang, Claire Louise Kulisa, Thierry Louat, Judi Charlotte Neuss, James Thomas Reuberson, Bart Vanderhoydonck
  • Therapeutically active pyrazolo-pyrimidine derivatives
    Patent number: RE48622
    Abstract: A series of pyrazolo[3,4-d]pyrimidine derivatives that are substituted at the 4-position by a diaza monocyclic, bridged bicyclic or spirocyclic moiety, are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases and malaria; and organ and cell transplant rejection.
    Type: Grant
    Filed: July 22, 2019
    Date of Patent: July 6, 2021
    Assignees: UCB Biopharma SRL, Katholieke Universiteit Leuven, K.U. Leuven R&D
    Inventors: Daniel James Ford, Richard Jeremy Franklin, Anant Ramrao Ghawalkar, Helen Tracey Horsley, Qiuya Huang, James Thomas Reuberson, Bart Vanderhoydonck