Abstract: A surgical instrument includes a housing having a shaft extending distally from the housing and an end effector disposed at a distal end of the shaft with first and second jaw members. The jaw members are moveable relative to one another from a first, open configuration spaced relative to one another, to a second, closed configuration. The first jaw member includes a sealing plate having proximal and distal segments each adapted to connect to an energy source via a single, wired connection and the second jaw member includes a sealing plate adapted to connect to the energy source. A resistor is disposed in circuit and is electrically coupled to the energy source. The resistor is configured to regulate the flow of energy to the proximal segment of the first jaw member via the single wired connection upon activation and until the jaw members reach the second configuration.

Abstract: Complexes of coronavirus spike proteins, as well as fragments or mutants thereof wherein the fragment or mutant thereof at least contains a receptor binding domain of said coronavirus spike protein, with linoleic acid, or a derivative or a salt or a mimetic thereof. Methods for producing the complexes of the invention by incubating coronavirus spike proteins with linoleic acid or a derivative or a salt or a mimetic thereof. . In vitro methods for identifying molecules which have therapeutic potential for diseases caused by coronaviruses by contacting the molecule with a coronavirus spike protein and linoleic acid or a derivative or salt or mimetic thereof. A method of treatment of coronavirus infection by administration of linoleic acid, or a derivative, a salt or a mimetic thereof to a subject in need thereof, by administration of an aerosol formulation or dry powder formulation to the respiratory tract, preferably by nasal administration.

Abstract: An assay device for detection or determination of an analyte in a sample uses opposable components and is suitable for assay of human chorionic gonadotropin and other protein or glycoprotein hormones.