Abstract: Disclosed herein are caged haptens and caged hapten-antibody conjugates useful for enabling the detection of targets located proximally to each other in a sample.

Abstract: Formulations and methods for reducing blood glucose and/or increasing insulin signaling in a subject have been developed. The formulations include SBI-477 and compounds based on SBI-477 i.e., SBI-477 analogs (collectively, SBI-477 compounds) and/or Mondo family inhibitors, in an effective amount to inhibit intracellular lipid accumulation and/or increase cellular glucose uptake when compared to levels in a control subject not administered the composition. Also disclosed are methods of reducing intracellular lipid accumulation and/or increase glucose uptake in a subject in need thereof. The method includes administering to the subject an effective amount of SBI-477 compounds and/or Mondo family inhibitor to reducing intracellular lipid accumulation and/or increase glucose uptake in the subject.

Abstract: Disclosed herein are caged haptens and caged hapten-antibody conjugates useful for enabling the detection of targets located proximally to each other in a sample.

Abstract: Formulations and methods for reducing blood glucose and/or increasing insulin signaling in a subject have been developed. The formulations include SBI-477 and compounds based on SBI-477 i.e., SBI-477 analogs (collectively, SBI-477 compounds) and/or Mondo family inhibitors, in an effective amount to inhibit intracellular lipid accumulation and/or increase cellular glucose uptake when compared to levels in a control subject not administered the composition. Also disclosed are methods of reducing intracellular lipid accumulation and/or increase glucose uptake in a subject in need thereof. The method includes administering to the subject an effective amount of SBI-477 compounds and/or Mondo family inhibitor to reducing intracellular lipid accumulation and/or increase glucose uptake in the subject.

Abstract: A storage unit for storing one or more storable members. The storage unit includes a housing configured to support at least one storage tunnel. The storage tunnel is defined by a circumferential wall extending about a central axis with the circumferential wall having a minimum distance from the central axis. A support cradle is defined along a lower portion of the tunnel and includes at least one longitudinal rail extending parallel with the central axis. The at least one longitudinal rail has a support surface which is at a distance from the central axis which is less than the minimum distance of the circumferential wall.

Abstract: A pallet including a pallet deck supported along a base plane. The pallet deck defines a load support surface within a given perimeter. The pallet deck includes at least one hand hole extending therethrough. The at least one hand hole is defined by a circumferential wall extending below the load support surface. The circumferential wall has a lower edge with a curved surface defined along at least a portion of the lower edge of the circumferential wall.

Abstract: A hand settable fuze interfaces with a servomotor to deploy a net from a projectile in flight. Prior to launch, a dial is rotated to both power on the fuze and set a preset delay. The projectile is then launched from a launcher system to deliver the stowed net rapidly and accurately toward a target. After the preset delay, the net is deployed from the projectile toward the target by operation of the servomotor.

Abstract: A pallet assembly for transporting a transportable unit. The pallet assembly includes a first pallet member including a support surface with at least one wall extending upwardly therefrom and a second pallet member including a support surface with at least one wall extending therefrom. A band is configured to be secured about the at least one wall of both the first and second pallet members after the transportable unit is positioned on both the first and second pallet member support surfaces such that a unified structure for transport is formed.

Abstract: A pallet base structure including a center deck defining a support surface extending between opposed sides and having at least two lugs extending from each of the opposed sides. A pair of base side members are positioned along respective sides of the center deck. Each base side member has first and second spaced apart base legs and a support member extending between the base legs with at least two corresponding lug receiving slots defined in the support member. The respective lugs are received in the respective lug receiving slots such that the center deck support surface is aligned with an upper surface of each support member to define a planar pallet surface. A packaging system incorporating the pallet base structure is also described.

Abstract: An apparatus includes a processor and storage to store instructions that cause the processor to identify at least one correlation between a diagnosis group and a medication class for each patient of a first set of patients to derive a set of models for each diagnosis group that correlates the diagnosis group to at least one medication class based on the at least one identified correlation; and for each patient of a second set of patients, employ each model of each set of models to make at least one prediction of at least one diagnosis group as indicated in the corresponding diagnosis group record based on at least one medication class indicated in the corresponding medication class record, and compare the at least one prediction to the corresponding diagnosis group record to derive a tally of at least one of true positives or false positives for each prediction.

Abstract: Described are systems and methods that enable users to virtually experience an environment at a destination location from their own user device, control their experience and even interact with others that are physically located within the environment. Likewise, the user's experience may even be improved with the inclusion of enhancements that are presented to the user as the user experiences the environment. User's may interact with the enhancements to obtain additional enhancements, interact with others physically located within the environment, interact with and direct a guide that is physically located within the environment, and receive near real-time video and audio that is transmitted from a guide device located within the environment.

Abstract: A dispenser transport pallet assembly for transporting a dispenser having a given configuration. The assembly includes a base member having a body with a lower surface and an upper surface. A plurality of rail members extend upward from the upper surface to define a plurality of lower cavities. A top cap has a cover surface with a plurality of rail members extending downward from an inner surface thereof to define a plurality of upper cavities. Each of the upper cavities is aligned with a respective lower cavity and each pair of upper and lower cavities is configured to receive and retain a respective dispenser.

Abstract: Described are systems and methods that enable users to virtually experience an environment at a destination location from their own user device, control their experience and even interact with others that are physically located within the environment. Likewise, the user's experience may even be improved with the inclusion of enhancements that are presented to the user as the user experiences the environment. User's may interact with the enhancements to obtain additional enhancements, interact with others physically located within the environment, interact with and direct a guide that is physically located within the environment, and receive near real-time video and audio that is transmitted from a guide device located within the environment.

Abstract: Described are systems and methods that enable users to virtually experience an environment at a destination location from their own user device, control their experience and even interact with others that are physically located within the environment. Likewise, the user's experience may even be improved with the inclusion of enhancements that are presented to the user as the user experiences the environment. User's may interact with the enhancements to obtain additional enhancements, interact with others physically located within the environment, interact with and direct a guide that is physically located within the environment, and receive near real-time video and audio that is transmitted from a guide device located within the environment.

Abstract: Particular disclosed embodiments disclosed herein concern using a one or more various mass tags, which can be specifically deposited at targets through direct or indirect enzymatic-catalyzed transformation, to provide a method for identifying targets in tissue samples. The mass tags may be labeled with stable isotopes to produce mass tags having the same chemical structure but different masses. Mass codes produced by ionizing the mass tags are detected and/or quantified using mass spectrometry. The method can be used for multiplexed detection of multiple targets in a particular sample. In some embodiments, a map divided into sections representing sections of the tissue sample may be prepared, with the map sections including data corresponding to quantification data wherein the size of a mass peak is determined and correlated with the amount of a target for the corresponding tissue sample section.

Abstract: A method, performed by one or more processors, including receiving a plurality of system event records; processing the plurality of system event records using a set of event detectors to determine that a suspicious system event has occurred; sending, to a client device, a plurality of properties associated with the suspicious system event; receiving, from the client device, a selection indicator indicating a selected one or more properties of the plurality of properties; generating one or more new event detectors based on the selected one or more properties; and adding the one or more new event detectors to the set of event detectors.