Patents by Inventor Daniel Lockhart
Daniel Lockhart has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210024877Abstract: Methods for separating microorganisms from non-microorganism cells in a non-microorganism cell-containing sample comprise incubating the sample with particles to form particle-microorganism complexes and then separating the particle-microorganism complexes from the non-microorganism cells. These methods are used to detect the absence or presence of a microorganism in a sample that also contains non-microorganism cells. Particular reagents and combinations of reagents enhance the selective capture of microorganisms in mixed samples. Corresponding compositions and kits are also provided.Type: ApplicationFiled: April 3, 2019Publication date: January 28, 2021Inventors: Daniel Lockhart, Paul Jay, James Turner, Andrew Rogers, Matthew Crow, William Mullen
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Patent number: 10805161Abstract: Disclosed are different implementations for rapid configuration propagation across multiple servers of a distributed platform. One implementation is a push based distribution of update segments that are generated from a onetime differential analysis of an updated particular configuration relative to a previous instance of the particular configuration. Sequence numbers attached to the updated segments identify is a server's copy of a configuration is up-to-date and can receive a new updated segment or if missing intervening segments are to be retrieved from peers and applied prior to applying the new updated segment. Another implementation is a pull based distribution of compressed images of the configurations. A complete set of configurations are distributed as a compressed file system that is loaded into server memory. Individual configurations are read out of the file system and loaded into memory when implicated by client requests.Type: GrantFiled: September 13, 2017Date of Patent: October 13, 2020Assignee: Verizon Digital Media Services Inc.Inventors: Daniel Lockhart, Derek Shiell, Harkeerat Bedi, Paulo Tioseco, William Rosecrans, David Andrews
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Publication number: 20190081862Abstract: Disclosed are different implementations for rapid configuration propagation across multiple servers of a distributed platform. One implementation is a push based distribution of update segments that are generated from a onetime differential analysis of an updated particular configuration relative to a previous instance of the particular configuration. Sequence numbers attached to the updated segments identify is a server's copy of a configuration is up-to-date and can receive a new updated segment or if missing intervening segments are to be retrieved from peers and applied prior to applying the new updated segment. Another implementation is a pull based distribution of compressed images of the configurations. A complete set of configurations are distributed as a compressed file system that is loaded into server memory. Individual configurations are read out of the file system and loaded into memory when implicated by client requests.Type: ApplicationFiled: September 13, 2017Publication date: March 14, 2019Inventors: Daniel Lockhart, Derek Shiell, Harkeerat Bedi, Paulo Tioseco, William Rosecrans, David Andrews
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Patent number: 9522120Abstract: The present invention includes compositions and methods for the controlled release of active agents in a shelf-stable liquid formulation by blending one or more controlled release microbeads comprising one or more active agents, preparing a dense, thixotropic solution having a density that is at, or about, the density of the one or more microbeads comprising a thixotropic agent, water and one or more preservatives under conditions that reduce bubble formation and mixing the microbeads and the thixotropic solutions in a mixer that lacks scraping paddles.Type: GrantFiled: October 3, 2013Date of Patent: December 20, 2016Assignee: NEOS THERAPEUTICS, LPInventors: Mark Tengler, Paul Taskey, Daniel Lockhart, Russell McMahen
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Methods of formulating and designing liquid drug suspensions containing ion exchange resin particles
Patent number: 9057675Abstract: The invention relates to the formulation and quality control of liquid drug suspensions. In particular, the invention relates to methods of formulating liquid suspensions comprising drug-containing resin particles. The invention also relates to methods of confirming the acceptability of drug-containing resin particles for use in formulating liquid drug suspensions. The invention further relates to methods of formulating liquid suspensions in which drug-containing resin particles, the liquid suspension, or both are modified to achieve a desired in vitro dissolution profile. The invention also relates to a novel dissolution method and methods of predicting in vivo bioequivalence based on in vitro dissolution methods.Type: GrantFiled: May 29, 2013Date of Patent: June 16, 2015Assignee: NEOS THERAPEUTICS, LPInventors: Russell McMahen, Mark Tengler, Michael Sloane, Daniel Lockhart -
Publication number: 20140093577Abstract: The present invention includes compositions and methods for the controlled release of active agents in a shelf-stable liquid formulation by blending one or more controlled release microbeads comprising one or more active agents, preparing a dense, thixotropic solution having a density that is at, or about, the density of the one or more microbeads comprising a thixotropic agent, water and one or more preservatives under conditions that reduce bubble formation and mixing the microbeads and the thixotropic solutions in a mixer that lacks scraping paddles.Type: ApplicationFiled: October 3, 2013Publication date: April 3, 2014Applicant: NEOS THERAPEUTICS, LPInventors: Mark TENGLER, Paul Taskey, Daniel Lockhart, Russell McMahen
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Methods of Formulating and Designing Liquid Drug Suspensions Containing Ion Exchange Resin Particles
Publication number: 20140033806Abstract: The invention relates to the formulation and quality control of liquid drug suspensions. In particular, the invention relates to methods of formulating liquid suspensions comprising drug-containing resin particles. The invention also relates to methods of confirming the acceptability of drug-containing resin particles for use in formulating liquid drug suspensions. The invention further relates to methods of formulating liquid suspensions in which drug-containing resin particles, the liquid suspension, or both are modified to achieve a desired in vitro dissolution profile. The invention also relates to a novel dissolution method and methods of predicting in vivo bioequivalence based on in vitro dissolution methods.Type: ApplicationFiled: May 29, 2013Publication date: February 6, 2014Applicant: NEOS THERAPEUTICS, LPInventors: Russell McMAHEN, Mark Tengler, Michael Sloane, Daniel Lockhart -
Methods of formulating and designing liquid drug suspensions containing ion exchange resin particles
Patent number: 8512759Abstract: The invention relates to the formulation and quality control of liquid drug suspensions. In particular, the invention relates to methods of formulating liquid suspensions comprising drug-containing resin particles. The invention also relates to methods of confirming the acceptability of drug-containing resin particles for use in formulating liquid drug suspensions. The invention further relates to methods of formulating liquid suspensions in which drug-containing resin particles, the liquid suspension, or both are modified to achieve a desired in vitro dissolution profile. The invention also relates to a novel dissolution method and methods of predicting in vivo bioequivalence based on in vitro dissolution methods.Type: GrantFiled: June 7, 2012Date of Patent: August 20, 2013Assignee: Neos Therapeutics, LPInventors: Russell McMahen, Mark Tengler, Michael Sloane, Daniel Lockhart -
Patent number: 8470375Abstract: The invention relates to the formulation and quality control of liquid drug suspensions. In particular, the invention relates to methods of formulating liquid suspensions comprising drug-containing resin particles. The invention also relates to methods of confirming the acceptability of drug-containing resin particles for use in formulating liquid drug suspensions. The invention further relates to methods of formulating liquid suspensions in which drug-containing resin particles, the liquid suspension, or both are modified to achieve a desired in vitro dissolution profile. The invention also relates to a novel dissolution method and methods of predicting in vivo bioequivalence based on in vitro dissolution methods.Type: GrantFiled: January 5, 2011Date of Patent: June 25, 2013Assignee: NEOS Therapeutics, LPInventors: Russell McMahen, Mark Tengler, Michael Sloane, Daniel Lockhart
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Publication number: 20130084340Abstract: The present invention includes compositions and methods for the controlled release of active agents in a shelf-stable liquid formulation by blending one or more controlled release microbeads comprising one or more active agents, preparing a dense, thixotropic solution having a density that is at, or about, the density of the one or more microbeads comprising a thixotropic agent, water and one or more preservatives under conditions that reduce bubble formation and mixing the microbeads and the thixotropic solutions in a mixer that lacks scraping paddles.Type: ApplicationFiled: November 26, 2012Publication date: April 4, 2013Applicant: NEOS THERAPEUTICS, LPInventors: Mark Tengler, Paul Taskey, Daniel Lockhart, Russell McMahen
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Patent number: 8318210Abstract: The present invention includes compositions and methods for the controlled release of active agents in a shelf-stable liquid formulation by blending one or more controlled release microbeads comprising one or more active agents, preparing a dense, thixotropic solution having a density that is at, or about, the density of the one or more microbeads comprising a thixotropic agent, water and one or more preservatives under conditions that reduce bubble formation and mixing the microbeads and the thixotropic solutions in a mixer that lacks scraping paddles.Type: GrantFiled: February 28, 2005Date of Patent: November 27, 2012Assignee: Neos Therapeutics, LPInventors: Mark Tengler, Paul Taskey, Daniel Lockhart, Russ McMahen
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Publication number: 20070074781Abstract: Systems, methods and media for faster filling of bags with material are disclosed. An accelerating mechanism accelerates material flowing through a chute from a material supply to a bag of a bag supplier.Type: ApplicationFiled: September 9, 2005Publication date: April 5, 2007Inventor: Daniel Lockhart
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Publication number: 20060193877Abstract: The present invention includes compositions and methods for the controlled release of active agents in a shelf-stable liquid formulation by blending one or more controlled release microbeads comprising one or more active agents, preparing a dense, thixotropic solution having a density that is at, or about, the density of the one or more microbeads comprising a thixotropic agent, water and one or more preservatives under conditions that reduce bubble formation and mixing the microbeads and the thixotropic solutions in a mixer that lacks scraping paddles.Type: ApplicationFiled: February 28, 2005Publication date: August 31, 2006Applicant: PFab, LPInventors: Mark Tengler, Paul Taskey, Daniel Lockhart, Russ McMahen