Abstract: Provided herein are methods of monitoring for the production of select antibodies in a non-human animal, comprising (a) immunizing a non-human animal with an immunogen; (b) obtaining a blood sample comprising antibody secreting cells (ASCs) from said non-human animal; and (c) individually assaying ASCs present in the blood sample, or a fraction thereof, for the production of select antibodies. Methods of guiding antibody production in a non-human animal for the production of select antibodies are also provided. In exemplary embodiments, the method comprises performing a cycle of (a) to (c), as above, and repeating the cycle when the percentage of ASCs producing select antibodies is below a threshold. In various aspects, the cycle is repeated until the percentage of ASCs producing select antibodies is at or above a threshold. Single cell assays are further provided herein.

Abstract: A bite registration device is provided that can be placed within a patient's mouth and adjusted to a desired position relative to the patient's maxillary and/or mandibular teeth while permitting visual inspection of the patient's anterior teeth during acquisition of the bite registration. The bite registration device is also configured to permit introduction of bite registration material without having to remove the device from the patient's mouth once optimal positioning has been established.

Abstract: A bite registration device is provided that can be placed within a patient's mouth and adjusted to a desired position relative to the patient's maxillary and/or mandibular teeth while permitting visual inspection of the patient's anterior teeth during acquisition of the bite registration. The bite registration device is also configured to permit introduction of bite registration material without having to remove the device from the patient's mouth once optimal positioning has been established.