Abstract: AAV capsid proteins comprising a modification in the amino acid sequence and virus vectors comprising the modified AAV capsid protein are described. Also described are methods of administering the virus vectors and virus capsids to a cell or to a subject in vivo.

Abstract: The present disclosure provides AAV capsid proteins comprising a modification in the amino acid sequence and virus vectors comprising the modified AAV capsid protein. The disclosure also provides methods of administering the vims vectors and virus capsids of the disclosure to a cell or to a subject in vivo.

Abstract: Provided herein are gene therapy compositions and methods for treating, preventing, and/or curing NPC1. More specifically, the disclosure provides Adeno-associated virus (AAV) vectors for delivery of nucleic acids and nucleic acids (including AAV transfer cassettes) for treating, preventing, and/or curing NPC1.

Abstract: The present disclosure provides recombinant AAV capsid proteins comprising a modification in the amino acid sequence and virus vectors comprising the recombinant AAV capsid proteins. The disclosure also provides methods of administering the virus vectors and vims capsids of the disclosure to a cell or to a subject in vivo.

Abstract: A patient support apparatus includes a sensor capable of detecting vital signs, setting acceptable limits for the vital signs, and includes structures for monitoring the vital signs and providing local and/or remote indications to caregivers if the vital signs fall outside of acceptable limits.

Abstract: Provided herein are gene therapy compositions and methods for treating, preventing, and/or curing NPC1. More specifically, the disclosure provides Adeno-associated virus (AAV) vectors for delivery of nucleic acids and nucleic acids (including AAV transfer cassettes) for treating, preventing, and/or curing NPC1.

Abstract: An electrode system for neurological monitoring is disclosed, including a housing with a recess dimensioned to hold an electrode. A conductive gel is applied to said electrode to limit direct contact by said electrode to a patient's skin. The recess defines a wall in said housing that engages the patient's skin. A thin bead of adhesive applied to the top surface of the wall secures the housing, and therefore the electrode, to the patient. Finer electrical conductor wires in a more flexible insulator lead from the electrode to a connector that fits into a neurological monitoring amplifier. The electrode system further comprising a template structure for precisely locating and adjusting to a patient's dimensions.

Abstract: A patient support apparatus includes a sensor capable of detecting vital signs, setting acceptable limits for the vital signs, and includes structures for monitoring the vital signs and providing local and/or remote indications to caregivers if the vital signs fall outside of acceptable limits.

Abstract: AAV capsid proteins comprising a modification in the amino acid sequence and virus vectors comprising the modified AAV capsid protein are described. Also described are methods of administering the virus vectors and virus capsids to a cell or to a subject in vivo.

Abstract: The present disclosure provides AAV capsid proteins comprising a modification in the amino acid sequence and virus vectors comprising the modified AAV capsid protein. The disclosure also provides methods of administering the virus vectors and virus capsids of the disclosure to a cell or to a subject in vivo.

Abstract: The present disclosure provides AAV capsid proteins comprising a modification in the amino acid sequence and virus vectors comprising the modified AAV capsid protein. The disclosure also provides methods of administering the vims vectors and vims capsids of the disclosure to a cell or to a subject in vivo.

Abstract: The present disclosure provides recombinant AAV capsid proteins comprising a modification in the amino acid sequence and virus vectors comprising the recombinant AAV capsid proteins. The disclosure also provides methods of administering the virus vectors and virus capsids of the disclosure to a cell or to a subject in vivo.

Abstract: A patient support apparatus includes a sensor capable of detecting vital signs, setting acceptable limits for the vital signs, and includes structures for monitoring the vital signs and providing local and/or remote indications to caregivers if the vital signs fall outside of acceptable limits.

Abstract: Provided herein are gene therapy compositions and methods for treating, preventing, and/or curing NPC1. More specifically, the disclosure provides Adeno-associated virus (AAV) vectors for delivery of nucleic acids and nucleic acids (including AAV transfer cassettes) for treating, preventing, and/or curing NPC1.

Abstract: An electrode system for neurological monitoring is disclosed, including a housing with a recess dimensioned to hold an electrode. A conductive is applied to said electrode to limit direct contact by said electrode to a patient's skin. The recess defines a wall in said housing that engages the patient's skin. A thin bead of adhesive applied to the top surface of the wall secures the housing, and therefore the electrode, to the patient. Finer electrical conductor wires in a more flexible insulator lead from the electrode to a connector that fits into a neurological monitoring amplifier.

Abstract: A patient support apparatus includes an upper frame that is movable to raise and lower relative to a base frame frame. A mattress support deck is coupled to the upper frame and includes a foot deck section. The foot deck section is movable with respect to the rest of the mattress support deck to raise and lower. A drainage bag support is coupled to the foot deck section and is configured to support a drainage bag. Control circuitry controls movement of the upper frame and the foot deck section. The control circuitry has a lockout mode to limit the movement of the upper frame and foot deck section to prevent the drainage bag from touching a floor.

Abstract: An electrode assembly for use in computer tomographic (CT) scans and magnetic resonance imaging (MRI) procedures include lead wires of 40 gauge copper electrical conductors, free of tin, in PVC insulation attached to electrodes. The electrodes, which may also be made of silver, gold or silver chloride or be made of metal-filled or metal-coated plastic, are attached to lead wires by any of the following (1) crimping using copper or polymer crimps; (2) shrink-wrap connections or ties, (3) radio frequency welding or heat staking; or (4) using conductive adhesives. The present electrode assembly reduces artifacts in the resulting images during CT scans and MRI procedures and thereby results in clearer images.

Abstract: A multi-electrode applicator includes a carrier with recesses formed in pre-selected locations on one side. Each recess carries an electrode, and optionally both an applicator and an electrode, so that, when that side of the carrier is applied to a surface, the electrodes engage the surface in their pre-selected locations. An adhesive is applied to the underside of the carrier to cause the carrier to stick to the skin surface. A release paper may be applied over the adhesive so that, when the paper is removed, the adhesive is exposed and the carrier can then be stuck to the skin. The carrier may be flat or curved, and the electrodes may be self-embedding electrodes, a stimulating- or recording-type electrode, or a ground electrode-reference electrode pair. Electrical conductor connects the electrode to a monitor directly or via a multi-pin connector.

Abstract: A system includes a monitoring electrode for neurological monitoring and operable to generate an analog electrical signal from brain activity of a patient; an analog-to-digital converter in electrical connection with the monitoring electrode; a transmitter in electrical connection with the analog-to-digital converter for transmitting a digital electrical signal corresponding to the analog signal; a receiver in electrical communication with the transmitter and operable to receive the transmission of the digital electrical signal; and a digital-to-analog converter in electrical connection with the receiver for converting the digital electrical signal received by the receiver back to an analog electrical signal for processing by an analog amplifier.

Abstract: A patient support apparatus includes an upper frame that is movable to raise and lower relative to a base frame frame. A mattress support deck is coupled to the upper frame and includes a foot deck section. The foot deck section is movable with respect to the rest of the mattress support deck to raise and lower. A drainage bag support is coupled to the foot deck section and is configured to support a drainage bag. Control circuitry controls movement of the upper frame and the foot deck section. The control circuitry has a lockout mode to limit the movement of the upper frame and foot deck section to prevent the drainage bag from touching a floor.