Abstract: The various implementations disclosed and contemplated herein relate to methods, systems, and devices for reducing or eliminating the pain of various procedures that pierce or otherwise generate pain in a patient's skin. Specific embodiments relate to devices and systems having at least two stimulation components that stimulate the target area with at least one of vibration and electrical stimulation. Some embodiments include stimulation components that are positioned on the fingers of the user, while other embodiments include a syringe-receiving component with stimulation components on flexible arms extending from the syringe-receiving component.

Abstract: The present invention relates to a method and composition for preventing surgical adhesions during surgery. Tissue surfaces and/or surgical articles involved in the surgery are separated by a biomaterial provided in the form of a non-crosslinked, decellularized and purified mammalian tissue (e.g. bovine pericardium). The biomaterial effectively inhibits fibrosis, scar formation, and surgical adhesions, while also serving as a scaffold for recellularization of the tissue site.

Abstract: A staple line buttress material having an adhesive surface, packaged and provided in sterile, ready-to-use form. The material can be used to retrofit surgical staplers to provide an improved staple line, and with improved ease of use.

Abstract: A combination medical device comprising a circular stapler instrument (4) and one or more portions of preformed buttress material (16) adapted to be stably positioned upon the staple cartridge (12) and/or anvil (14) components of the stapler (4) prior or at the time of use. Positioned buttress material(s) (16) are delivered to a tissue site where the circular stapler (4) is actuated to connect previously severed tissue portions. An embodiment of the invention allows tissue portions to be joined without the use of sutures. The buttress material (16) is made up of two regions, one of which serves primarily to secure the buttress material (16) to the stapler (4) prior to acuation, and one of which serves primarily to form the improved seal. The former region is severed and discarded upon activation of the circular stapler (4) to form anastomoses, while the remaining material secures and seals the newly connected tissue. Methods of use and preparation of the buttress material (16) are also described.

Abstract: The present invention relates to a method and composition for preventing surgical adhesions during surgery. Tissue surfaces and/or surgical articles involved in the surgery are separated by a biomaterial provided in the form of a non-crosslinked, decellularized and purified mammalian tissue (e.g. bovine pericardium). The biomaterial effectively inhibits fibrosis, scar formation, and surgical adhesions, while also serving as a scaffold for recellularization of the tissue site.