Abstract: Various embodiments relate to a microbeam radiation therapy (microbeam radiosurgery) system, including: a radiation beam source; a collimator with slits, wherein the collimator only passes a radiation beam from the radiation beam source through the slits; a filtering and limiting system; a source shutoff controller connected to the radiation beam source; and a detector configured to detect events requiring the shutdown of the radiation beam source.

Abstract: Various embodiments relate to a method of performing microbeam radiation therapy (microbeam radiosurgery) for a subject, including: producing a high-energy radiation beam; shaping, attenuating, strengthening, hardening and/or otherwise appropriately modifying the high-energy radiation beam using a low-Z, high-Z, or variable-Z filter; passing the beam before or after it has been so modified through a collimator to produce high-dose regions alternating with low-dose regions; and irradiating the subject with the collimated beam so modified.

Abstract: Various embodiments relate to a method of performing microbeam radiation therapy on a subject, including: producing a high-energy radiation beam in a first direction; producing planar microbeams using the high-energy radiation beam in the first direction, wherein the microbeams have a width, wherein the planar microbeams produce scattered electrons; and applying a magnetic field in a direction lying in a plane substantially parallel to the planar microbeams, wherein the strength of the magnetic field corresponds to the width of the microbeam.

Abstract: Various embodiments relate to a method of performing microbeam radiation therapy on a subject, including: producing a high-energy radiation beam in a first direction; producing planar microbeams using the high-energy radiation beam in the first direction, wherein the microbeams have a width, wherein the planar microbeams produce scattered electrons; and applying a magnetic field in a direction lying in a plane substantially parallel to the planar microbeams, wherein the strength of the magnetic field corresponds to the width of the microbeam.

Abstract: Various embodiments relate to a microbeam radiation therapy (microbeam radiosurgery) system, including: a radiation beam source; a collimator with slits, wherein the collimator only passes a radiation beam from the radiation beam source through the slits; a filtering and limiting system; a source shutoff controller connected to the radiation beam source; and a detector configured to detect events requiring the shutdown of the radiation beam source.

Abstract: Various embodiments relate to a method of performing microbeam radiation therapy on a subject, including: affixing a collimator to the subject at a first location; producing a first high energy radiation fan beam, wherein the width of the first fan beam in a first direction is greater than the width of the first fan beam in a second direction; and moving the subject in the second direction so that the first fan beam irradiates the subject through the collimator to produce first high dose regions alternating with first low dose regions.

Abstract: Various embodiments relate to a method of performing microbeam radiation therapy (microbeam radiosurgery) for a subject, including: producing a high-energy radiation beam; shaping, attenuating, strengthening, hardening and/or otherwise appropriately modifying the high-energy radiation beam using a low-Z, high-Z, or variable-Z filter; passing the beam before or after it has been so modified through a collimator to produce high-dose regions alternating with low-dose regions; and irradiating the subject with the collimated beam so modified.

Abstract: Various embodiments relate to a method of performing microbeam radiation therapy on a subject, including: affixing a collimator to the subject at a first location; producing a first high energy radiation fan beam, wherein the width of the first fan beam in a first direction is greater than the width of the first fan beam in a second direction; and moving the subject in the second direction so that the first fan beam irradiates the subject through the collimator to produce first high dose regions alternating with first low dose regions.

Abstract: The present invention provides methods of using metal nanoparticles 0.5 to 400 nm in diameter to enhance the dose and effectiveness of x-rays or of other kinds of radiation in therapeutic regimes of ablating a target tissue, such as tumor. The metal nanoparticles can be administered intravenously, intra-arterially, or locally to achieve specific loading in and around the target tissue. The metal nanoparticles can also be linked to chemical and/or biochemical moieties which bind specifically to the target tissue. The enhanced radiation methods can also be applied to ablate unwanted tissues or cells ex vivo.

Abstract: The present invention provides methods of using metal nanoparticles 0.5 to 400 nm in diameter to enhance the dose and effectiveness of x-rays or of other kinds of radiation in therapeutic regimes of ablating a target tissue, such as tumor. The metal nanoparticles can be administered intravenously, intra-arterially, or locally to achieve specific loading in and around the target tissue. The metal nanoparticles can also be linked to chemical and/or biochemical moieties which bind specifically to the target tissue. The enhanced radiation methods can also be applied to ablate unwanted tissues or cells ex vivo.

Abstract: The present invention provides methods of using metal nanoparticles 0.5 to 400 nm in diameter to enhance the dose and effectiveness of x-rays or of other kinds of radiation in therapeutic regimes of ablating a target tissue, such as tumor. The metal nanoparticles can be administered intravenously, intra-arterially, or locally to achieve specific loading in and around the target tissue. The metal nanoparticles can also be linked to chemical and/or biochemical moieties which bind specifically to the target tissue. The enhanced radiation methods can also be applied to ablate unwanted tissues or cells ex vivo.

Abstract: The present invention provides methods of using metal nanoparticles 0.5 to 400 nm in diameter to enhance the dose and effectiveness of x-rays or of other kinds of radiation in therapeutic regimes of ablating a target tissue such as tumor. The metal nanoparticles can be administered intravenously, intra-arterially, or locally to achieve specific loading in and around the target tissue. The metal nanoparticles can also be linked to chemical and/or biochemical moieties which bind specifically to the target tissue. The enhanced radiation methods can also be applied to ablate unwanted tissues or cells ex vivo.

Abstract: The present invention provides methods of using metal nanoparticles 0.5 to 400 nm in diameter to enhance the dose and effectiveness of x-rays or of other kinds of radiation in therapeutic regimes of ablating a target tissue such as tumor. The metal nanoparticles can be administered intravenously, intra-arterially, or locally to achieve specific loading in and around the target tissue. The metal nanoparticles can also be linked to chemical and/or biochemical moieties which bind specifically to the target tissue. The enhanced radiation methods can also be applied to ablate unwanted tissues or cells ex vivo.

Abstract: The present invention covers halogenated derivatives of boronated phorphyrins containing multiple carborane cages having the formula which selectively accumulate in neoplastic tissue within the irradiation volume and thus can be used in cancer therapies including, but not limited to, boron neutron-capture therapy and photodynamic therapy. The present invention also covers methods for using these halogenated derivatives of boronated porphyrins in tumor imaging and cancer treatment.

Abstract: Metal nanoparticles are described that are useful for enhancing the contrast of x-rays or other radiation sources. A method is disclosed whereby the agents are administered intravenously or intra-arterially to detect coronary senses and other vascular features. It is also disclosed how directing moieties attached to the metal particles are used to detect specific targets.

Abstract: The present invention provides methods of using metal nanoparticles 0.5 to 400 nm in diameter to enhance the dose and effectiveness of x-rays or of other kinds of radiation in therapeutic regimes of ablating a target tissue such as tumor. The metal nanoparticles can be administered intravenously, intra-arterially, or locally to achieve specific loading in and around the target tissue. The metal nanoparticles can also be linked to chemical and/or biochemical moieties which bind specifically to the target tissue. The enhanced radiation methods can also be applied to ablate unwanted tissues or cells ex vivo.

Abstract: The present invention covers radiosensitizers containing as an active ingredient halogenated derivatives of boronated porphyrins containing multiple carborane cages having the structure which selectively accumulate in neoplastic tissue within the irradiation volume and thus can be used in cancer therapies including, but not limited to, boron neutron—capture therapy and photodynamic therapy. The present invention also covers methods for using these radiosensitizers in tumor imaging and cancer treatment.

Abstract: The present invention covers halogenated derivatives of boronated phorphyrins containing multiple carborane cages having the formula 1

Abstract: The present invention covers halogenated derivatives of boronated porphyrins containing multiple carborane cages having the formula which selectively accumulate in neoplastic tissue within the irradiation volume and thus can be used in cancer therapies including, but not limited to, boron neutron- capture therapy and photodynamic therapy. The present invention also covers methods for using these halogenated derivatives of boronated porphyrins in tumor imaging and cancer treatment.

Abstract: The present invention covers radiosensitizers containing as an active ingredient halogenated derivatives of boronated porphyrins containing multiple carborane cages which selectively accumulate in neoplastic tissue within the irradiation volume and thus can be used in cancer therapies including, but not limited to, boron neutron-capture therapy and photodynamic therapy. The present invention also covers methods for using these radiosensitizers in tumor imaging and cancer treatment.