Abstract: The present disclosure relates to compositions and methods of engineered IgG Fc constructs, wherein the Fc constructs include one or more Fc domains.

Abstract: Fc-antigen binding constructs having a PD-L1 binding domain and two or more Fc domains are described as are methods for using such constructs. Also described are polypeptides making up such constructs. Fc domain monomers that are included in the constructs can include amino acid substitutions that promote homodimerization or heterodimerization.

Abstract: Glycoproteins having particular sialylation patterns, and methods of making and using such glycoproteins, are described.

Abstract: Glycoproteins having particular sialylation patterns, and methods of making and using such glycoproteins, are described.

Abstract: The present invention discloses a system comprising a method and apparatus that integrates learning across interchangeable, multiple literacies and provides a means for increasing simultaneous literacy acquisition density. Information acquired through multiple senses results in more information acquired faster and with longer retention possible. The system presents information selectively through one or more sensory pathways, then interprets behavioral responses to this information, analyzing the responses qualitatively and quantitatively. Tracked and stored data is applied over various learning environments to develop individual learner profiles. In this way, the specific sensory pathways that an individual learner responds to can be optimized and specifically tailored for enhanced learning performance.

Abstract: A control system and control method of a wind farm which allows taking into account dynamic variations in the possibilities of reactive power generation of each wind turbine with respect to maximum reactive power generation capacities. The system calculates an initial torque and a maximum reactive power limit such that it is not necessary to apply limitations to the initial torque.

Abstract: A control system and control method of a wind farm allows taking into account dynamic variations in the possibilities of reactive power generation of each wind turbine with respect to maximum reactive power generation capacities. The system is configured to receive from at least one first wind turbine of the wind turbines of the wind farm a maximum reactive power limit desired lower than a minimum reactive power capacity required. The system is configured to calculate the individual reactive power setpoints for each of the at least two wind turbines of the wind farm such that the individual reactive power setpoint for the at least one first wind turbine of the wind farm does not exceed the maximum reactive power limit desired.

Abstract: The present disclosure relates to compositions and methods of engineered Fc-antigen binding domain constructs, where the Fc-antigen binding domain constructs include at least two Fc domains and at least one antigen binding domain.

Abstract: Glycoproteins having particular sialylation patterns, and methods of making and using such glycoproteins, are described.

Abstract: Mixing device and applicator for sealants formed by a main body and a handle (1), wherein the main body comprises a container-carrying sheath (7), a rotating cylinder (14), a gear module (11) that can be coupled to a rotor and a set of mechanisms that eject the sealant material. By actuating a trigger (2), a speed regulator (3) and a rotation selector (4) present in the handle (1) in a first action the cylinder (11) rotates in one sense mixing the material and in a second action it changes the sense of rotation and by actuating a cylinder locking system (19 and 20) present in the main body the device ejects the sealant material.

Abstract: The present disclosure relates to engineered IgG Fc constructs and uses thereof.

Abstract: Disclosed herein is a novel gene signature of metastatic cancer cells and a novel three-dimensional (3D) culture system for use in improved methods of predicting metastasis or prognosis in cancer. Accordingly, described herein are methods of determining a risk of metastasis, methods of predicting prognosis for cancer patients, methods of treating a cancer patient identified at high risk of metastasis, methods of treating a cancer patient identified as having poorer prognosis, methods for determining the migration capacity of a tumor, methods of screening a tumor for sensitivity to a drug, and kits for use in performing these methods.

Abstract: The present invention relates to engineered IgG Fc constructs and uses thereof.

Abstract: The present invention relates to compositions and methods of engineered IgG Fc constructs, wherein said Fc constructs include one or more Fc domains.

Abstract: The present invention discloses a system comprising a method and apparatus that integrates learning across interchangeable, multiple literacies and provides a means for increasing simultaneous literacy acquisition density. Information acquired through multiple senses results in more information acquired faster and with longer retention possible. The system presents information selectively through one or more sensory pathways, then interprets behavioral responses to this information, analyzing the responses qualitatively and quantitatively. Tracked and stored data is applied over various learning environments to develop individual learner profiles. In this way, the specific sensory pathways that an individual learner responds to can be optimized and specifically tailored for enhanced learning performance.

Abstract: A bracket for supporting a vehicle control module, such as a powertrain control module, is disclosed. The bracket includes a body having a base wall, nodes or support posts, and side walls. The base wall includes back and module-receiving sides. An array of intersecting ribs is formed on the back side while at least one array of honeycomb segments is formed on the module-receiving side. At least one of the honeycomb segments includes a top layer. Substrate attachment arms extend outwardly from the side walls. Support posts extend from the back side of the base wall. Three intersecting ribs are provided, generally forming a triangle. One or more additional ribs may be provided. The intersecting ribs are hollow. The individual ribs function as structural beams that connect to and thus work in conjunction with the nodes or support posts and the honeycomb to provide optimum stiffness to the bracket.

Abstract: The present invention relates to compositions and methods of engineered IgG Fc constructs, wherein said Fc constructs include one or more Fc domains.

Abstract: Glycoproteins having particular sialylation patterns, and methods of making and using such glycoproteins, are described.