Patents by Inventor Daniel P. C. McGee

Daniel P. C. McGee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of 2'-O-alkyl guanosine and related compounds
    Patent number: 5506351
    Abstract: An improved process for preparing 2'-O-substituted guanosine comprising reacting an unprotected 2,6-diaminopurine riboside with an alkyl halide in the presence of a sodium hydride or a base of equal strength followed by a deamination step with adenosine deaminase. Such modified guanosine molecules can be used to synthesize 2'-O-modified oligonucleotides. The above alkylating process can also be used to prepare 3'-O-alkyl- and 2',3'-di-O-alkyl-2,6-diaminopurine ribosides. The deamination of these nucleosides yields the corresponding guanosine derivatives.
    Type: Grant
    Filed: July 23, 1992
    Date of Patent: April 9, 1996
    Assignee: ISIS Pharmaceuticals
    Inventor: Daniel P. C. McGee
  • Pharmacologically active compound and use
    Patent number: 5420156
    Abstract: 1-Ethylphenoxathiin 10,10-dioxide (I) ##STR1## inhibits monoamine oxidase-A and is useful in the treatment of disorders such as depression.
    Type: Grant
    Filed: December 8, 1993
    Date of Patent: May 30, 1995
    Assignee: Burroughs Wellcome Co.
    Inventors: Morton Harfenist, Daniel P. C. McGee, Helen L. White, Barrett R. Cooper
  • Tricyclic derivatives of substituted pyrimidines
    Patent number: 4704392
    Abstract: Compounds useful as antiviral agents are depicted in the formula: ##STR1## wherein: X is oxygen or NH, Y is hydrogen, iodo, fluoro, methyl or trifluoromethyl, Z is hydrogen or fluoro and Z' is fluoro; and the wavy line indicates that the group may be above or below the plane of the ring; and the pharmaceutically acceptable acid addition salts thereof.
    Type: Grant
    Filed: April 14, 1986
    Date of Patent: November 3, 1987
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Julien P. H. Verheyden, John C. Martin, G. V. Bindu Madhavan, Daniel P. C. McGee, Ernest J. Prisbe
  • Process for preparing 2,6-substituted-9-(1,3-dihydroxy-2-propoxymethyl)-purines and certain derivatives
    Patent number: 4621140
    Abstract: Process and novel intermediates for preparing 9-(1,3-dihydroxy-2-propoxymethyl)guanine and 2,6-diamino-9-(1,3-dihydroxy-2-propoxymethyl)purine and certain esters thereof. The present process and intermediates reduce the number of reaction steps to prepare these compounds as compared to prior processes. The products are useful as antiviral agents.
    Type: Grant
    Filed: February 23, 1984
    Date of Patent: November 4, 1986
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Julien P. H. Verheyden, John C. Martin, Daniel P. C. McGee
  • Purinyl or pyrimidinyl substituted hydroxycyclopentane compounds useful as antivirals
    Patent number: 4605659
    Abstract: Novel 4-substituted-5-hydroxymethyl-1,2-cyclopentanediols or 1-cyclopentanol substituted at the 3-position by various heterocyclic groups are useful as antiviral agents.
    Type: Grant
    Filed: April 30, 1985
    Date of Patent: August 12, 1986
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Julien P. H. Verheyden, John C. Martin, G. V. Bindu Madhaven, Daniel P. C. McGee, Ernest J. Prisbe
  • Process for preparing the cyclic phosphate ester of substituted 9-(1,3-dihydroxy-2-propoxymethyl)purines
    Patent number: 4590269
    Abstract: An improved process for preparing the cyclic phosphate ester of substituted 9-(1,3-dihydroxy-2-propoxymethyl)purines which are useful as antiviral agents.
    Type: Grant
    Filed: March 29, 1984
    Date of Patent: May 20, 1986
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Ernest J. Prisbe, Daniel P. C. McGee