Abstract: A conductive member such as conductive pad (1) for use in radiofrequency ablation, the conductive member being flexible so as to conform to a subject's skin, the conductive member comprising a conductive skin contact layer (5) arranged for contact with the subject's skin and a conductive layer (4) over the conductive skin contact layer, in which the conductive skin contact layer (5) and the conductive layer (4) are both conductive to DC electrical signals.

Abstract: A tissue splayer (76) is described which includes an index finger portion (4) and a middle finger portion (5). The tissue splayer also includes a first pivot joint (80) coupling the index finger portion (4) to the middle finger portion (5) to permit the middle finger portion (5) to rotate relative to the index finger portion (4) about a first pivot axis (81). The tissue splayer (76) also includes a first splay mechanism (88) configured to permit rotation of the middle finger portion (5) away from the index finger portion (4) about the first pivot axis, and to resist rotation of the middle finger portion (5) towards the index finger portion (4) about the first pivot axis (81).

Abstract: A device for controlling a fluid flow in an array of fluid pathways on a microfluidic chip is provided. The device comprising: two or more resistors provided upstream of the chip wherein each upstream resistor is configured to provide a resistance at an upstream end of a fluid pathway; two or more resistors provided downstream of the chip wherein each downstream resistor is configured to provide a resistance at a downstream end of a fluid pathway, wherein the values of the resistances are selected in order to control a proportion of fluid that flows through each fluid pathway.

Abstract: A device for controlling a fluid flow in an array of fluid pathways on a microfluidic chip is provided. The device comprising: two or more resistors provided upstream of the chip wherein each upstream resistor is configured to provide a resistance at an upstream end of a fluid pathway; two or more resistors provided downstream of the chip wherein each downstream resistor is configured to provide a resistance at a downstream end of a fluid pathway, wherein the values of the resistances are selected in order to control a proportion of fluid that flows through each fluid pathway.

Abstract: A sample capture and transport unit comprises a housing defining a substrate chamber for containing a sample-capture substrate. The housing comprises at least a first part and a second part which are movable relative to one another ? i) from a first closed configuration in which the substrate chamber is inaccessible; ? ii) to a first open configuration in which access to the substrate chamber is enabled to allow capturing of a skin-print on a sample-capture substrate contained within the substrate chamber; and subsequently ? iii) into a second closed configuration in which the substrate chamber is again inaccessible. The unit further comprises a retaining mechanism for retaining it in the second closed configuration. The retaining mechanism is disablable to permit movement of the unit out of the second closed configuration. A sample can be obtained at a first location, secured for transport and analysed at a second location.

Abstract: A method of analyzing a skin-print provided on a first surface of an optically transparent substrate. The method comprises the steps of exposing the skin-print on the first surface of the optically transparent substrate to one or more reagents selected to bind with one or more metabolites present in the skin-print; transmitting electromagnetic radiation onto the skin-print through the optically transparent substrate using a radiation source to thereby produce an optical signal of said one or more reagents and/or said one or more metabolites; and detecting an optical image of the optical signal through the optically transparent substrate using a sensor. Also a skin-print analysis apparatus and a reagent cartridge for use in carrying out the method.

Abstract: A method of analysing a skin-print provided on a first surface of an optically transparent substrate. The method comprises the steps of exposing the skin-print on the first surface of the optically transparent substrate to one or more reagents selected to bind with one or more metabolites present in the skin-print; transmitting electromagnetic radiation onto the skin-print through the optically transparent substrate using a radiation source to thereby produce an optical signal of said one or more reagents and/or said one or more metabolites; and detecting an optical image of the optical signal through the optically transparent substrate using a sensor. Also a skin-print analysis apparatus and a reagent cartridge for use in carrying out the method.

Abstract: A sample capture and transport unit comprises a housing defming a substrate chamber for containing a sample-capture substrate. The housing comprises at least a first part and a second part which are movable relative to one another • i) from a first closed configuration in which the substrate chamber is inaccessible; • ii) to a first open configuration in which access to the substrate chamber is enabled to allow capturing of a skin-print on a sample-capture substrate contained within the substrate chamber; and subsequently • iii) into a second closed configuration in which the substrate chamber is again inaccessible. The unit further comprises a retaining mechanism for retaining it in the second closed configuration. The retaining mechanism is disablable to permit movement of the unit out of the second closed configuration. A sample can be obtained at a first location, secured for transport and analysed at a second location.

Abstract: A pump driver, a disposable pump cartridge for use with the pump driver and a beverage dispenser employing the pump drive are disclosed. The disposable pump cartridge comprises at least one barrel 20 having an inlet valve 24 and an outlet valve 26 associated therewith. A piston 28 movable within the barrel 20 is retained in a minimum volume position during transit by a protrusion 22 on the internal surface of the barrel 20. The piston 20 has a piston shaft 28 with a hollow end arranged, in use, to releasably engage a piston driver to drive the piston 28 from its minimum volume position to an operative position, and to reciprocate the piston 28 within the barrel 20 in its operative position to draw fluid into and pump fluid from the barrel 20 via the inlet valve 24 and outlet valve 26 respectively. Methods of engaging, disengaging and changing the disposable pump cartridge are also disclosed.

Abstract: A controller is provided for maneuvering an interrogation plane relative to a reference surface. The interrogation plane intersects the reference surface and is associated with a pole about which the interrogation plane is rotatable. The pole has an adjustable angle of inclination relative to the reference surface. The controller has a base, a handle, and an arm extending from a connection with the base to a connection with the handle. The arm has hingable joints which hinge to allow the handle to be translated relative to the base in arbitrary directions across a user surface. The controller further has position sensors which measure the translation of the handle relative to the base on the user surface. The translation provides a corresponding translation of the interrogation plane relative to the reference surface. The handle is rotatable about a rotation axis and is tillable about a tilt axis to allow the handle to be angularly moved relative to the user surface.

Abstract: An obstetric vacuum extractor (20) comprises a cylinder (22) communicating with a cup (26), and a handle (46) connected to a piston (38) via an extensible bias element (52) to evacuate the cup. The bias element permits relative movement between the handle and the piston. The bias element limits force transmitted to the piston, and movement of the piston relative to the handle operates an indicator to confirm that low pressure has been maintained within the cup. A cup for such an extractor comprises inner (130) and outer (132) sections, at least the outer section being reconfigurable, by applying distal force to a proximal side of the cup, from a convex insertion state for insertion into a mother's birth canal into a concave engagement state for engagement with a baby's head. A boundary between the sections is shaped such that the inner section may be concave while the outer section is convex, to create an inner suction cup.

Abstract: This invention relates to medical devices for labelling a syringe filled from an ampoule, and to safer devices for filling a syringe from an ampoule, and to associated methods. We describe a device for attaching to an ampoule to label a syringe filled from the ampoule, the device comprising: an ampoule-mounting portion for mounting the device to a filled ampoule; a syringe-fitting portion to enable the device to be fitted onto said syringe; and a label holder to hold a label for contents of said ampoule; and wherein one of said syringe and said ampoule is detachable from said device; and wherein said label is configured such that in conjunction with a filling operation of said syringe and detachment of said one of said syringe and said ampoule from said device said syringe is labelled by said label.

Abstract: A controller is provided for manoeuvring an interrogation plane relative to a reference surface. The interrogation plane intersects the reference surface and is associated with a pole about which the interrogation plane is rotatable. The pole has an adjustable angle of inclination relative to the reference surface. The controller has a base, a handle, and an arm extending from a connection with the base to a connection with the handle. The arm has hingeable joints which hinge to allow the handle to be translated relative to the base in arbitrary directions across a user surface. The controller further has position sensors which measure the translation of the handle relative to the base on the user surface. The translation provides a corresponding translation of the interrogation plane relative to the reference surface. The handle is rotatable about a rotation axis and is tillable about a tilt axis to allow the handle to be angularly moved relative to the user surface.

Abstract: A docking mechanism provided for analytical apparatus, such as an acoustic bio-sensor apparatus. The mechanism is operable releasably to receive a cartridge (58) for use in analysing a sample comprising a fluid and having a flow cell (104, 106; 304, 306) for the sample and an electrically operated sensor (92) for performing the analysis. The docking mechanism has a clamping mechanism (12, 8, 10) for urging a fluid connector such as ferules (50, 52) against the cartridge to provide a fluid connection between the flow cell inlet and a sample delivery device.

Abstract: A cartridge for apparatus for analysing a sample comprising a fluid as a flow cell for receiving the sample. The cell is formed from a substantially rigid support surface (102), a sensor comprising an electrical mechanical transducer (92), for example a wafer of quartz crystal and adhesive means, such as double sided adhesive tape (100) attaching the sensor to the support surface. The support surface and sensor are spaced from each other by a membrane, which may form part of the double sides adhesive tape so as to define the flow cell between the support surface and the sensor. The flow cell also has an opening (for example, 111) through which, in use, the sample passes. The sensor, forming part of the flow cell, comes into contact with the sample to enable the sample to be analysed.

Abstract: A pump driver, a disposable pump cartridge for use with the pump driver and a beverage dispenser employing the pump drive are disclosed. The disposable pump cartridge comprises at least one barrel 20 having an inlet valve 24 and an outlet valve 26 associated therewith. A piston 28 movable within the barrel 20 is retained in a minimum volume position during transit by a protrusion 22 on the internal surface of the barrel 20. The piston 20 has a piston shaft 28 with a hollow end arranged, in use, to releasably engage a piston driver to drive the piston 28 from its minimum volume position to an operative position, and to reciprocate the piston 28 within the barrel 20 in its operative position to draw fluid into and pump fluid from the barrel 20 via the inlet valve 24 and outlet valve 26 respectively. Methods of engaging, disengaging and changing the disposable pump cartridge are also disclosed.

Abstract: A docking mechanism provided for analytical apparatus, such as an acoustic bio-sensor apparatus. The mechanism is operable releasably to receive a cartridge (58) for use in analysing a sample comprising a fluid and having a flow cell (104, 106; 304, 306) for the sample and an electrically operated sensor (92) for performing the analysis. The docking mechanism has a clamping mechanism (12, 8, 10) for urging fluid connector means such as ferules (50, 52) against the cartridge to provide a fluid connection between the flow cell inlet and a sample delivery means.

Abstract: A cartridge for apparatus for analysing a sample comprising a fluid as a flow cell for receiving the sample. The cell is formed from a substantially rigid support surface (102), a sensor comprising an electrical mechanical transducer (92), for example a wafer of quartz crystal and adhesive means, such as double sided adhesive tape (100) attaching the sensor to the support surface. The support surface and sensor are spaced from each other by a membrane, which may form part of the double sides adhesive tape so as to define the flow cell between the support surface and the sensor. The flow cell also has an opening (for example, 111) through which, in use, the sample passes. The sensor, forming part of the flow cell, comes into contact with the sample to enable the sample to be analysed.

Abstract: The invention provides an inhaler of the non-reservoir kind (i.e. one which operates by dispensing individually packaged doses) characterised by the feature that a moisture-proof barrier—which may optionally comprise substantially or partly an external region of the inhaler-encloses the dose-storage region of the inhaler without enclosing the doses individually, and incorporates a similarly moisture-proof aperture through which the medicament doses can, in use, be individually dispensed. The invention also provides a method of filling such an inhaler.