Abstract: A device case for a portable electronic device includes a device stand attached to a hack surface of the case housing. The device stand is formed by an inner stand and outer stand connected by releasable hinged connections to the back surface of the case housing. A track is formed on a surface of the outer stand that the inner stand slides along. A locking portion such as a cavity or channel on the outer stand locks the inner stand into an open position with respect to the outer stand. At least a portion of the outer stand is flexible such that applying a threshold pressure to the device case causes the portion of the outer stand to flex such that the locking portion releases the inner and outer stand from the open position without damaging the stand.

Abstract: The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.

Abstract: A water resistant device case includes a front and back assembly that mate to enclose an electronic device. The front assembly includes a rigid front frame, a touch screen cover bonded to the front frame, an inner bumper attached to the rigid front frame and an elastomeric main seal attached around a periphery of the rigid front frame. The back assembly includes a rigid back frame, an elastomeric over mold formed on an exterior of the back frame and an inner bumper attached to the rigid back frame. A snap tab attached to the rigid back frame mates with a snap hook on the front assembly to hold the front and back assemblies together when the device is enclosed within the case. A main water resistant seal is formed around a perimeter of the front and back assemblies by the elastomeric main seal on the front assembly being held against an inner surface of the rigid back frame.

Abstract: The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.

Abstract: A protective case for a portable electronic device includes a rigid plastic frame bonded to a stretchable rubber cover and a back panel insert that can be removably inserted into a pocket in the rear of the stretchable rubber cover and plastic frame. To position a device in the case, the device is simply inserted into the front opening of the rigid plastic frame and stretchable rubber cover such that the edges of the stretchable cover stretch over the device and secure the device in the case. A variety of different removable back panels allow the stand to be easily reconfigured to include a stand for the device case, a pocket adapted to hold payment cards, a folding style wallet, a mirror or a fabric covering.

Abstract: A water resistant device case includes a front and back assembly that mate to enclose an electronic device. The front assembly includes a rigid front frame, a touch screen cover bonded to the front frame, an inner bumper attached to the rigid front frame and an elastomeric main seal attached around a periphery of the rigid front frame. The back assembly includes a rigid back frame, an elastomeric over mold formed on an exterior of the black frame and an inner bumper attached to the rigid back frame. A snap tab attached to the rigid back frame mates with a snap hook on the front assembly to hold the front and back assemblies together when the device is enclosed within the case. A main water resistant seal is formed around a perimeter of the front and back assemblies by the elastomeric main seal on the front assembly being held against an inner surface of the rigid back frame.

Abstract: A protective case for a portable electronic device includes a back frame and a front cover. The back frame has a rigid plastic back frame with an elastomeric material bonded to portions of the plastic frame. An elastomeric insert is positioned around a portion of the interior perimeter of the back frame to provide impact resistance. Back frame engagement members are positioned on the perimeter of the rigid plastic back frame. The front cover mates with the back frame to enclose the elastomeric insert and the device. The front cover includes a touch screen cover and a rigid plastic front frame bonded to a perimeter of the touch screen cover. Front cover engagement members extend from the rigid plastic front frame that engage the back frame engagement members to hold the front cover on the back frame and enclose the device.

Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.

Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.

Abstract: A protective case for a portable electronic device includes a rigid plastic frame bonded to a stretchable rubber cover and a back panel insert that can be removably inserted into a pocket in the rear of the stretchable rubber cover and plastic frame. To position a device in the case, the device is simply inserted into the front opening of the rigid plastic frame and stretchable rubber cover such that the edges of the stretchable cover stretch over the device and secure the device in the case. A variety of different removable back panels allow the stand to be easily reconfigured to include a stand for the device case, a pocket adapted to hold payment cards, a folding style wallet, a mirror or a fabric covering.

Abstract: A device case for a portable electronic device includes a device stand attached to a back surface of the case housing. The device stand is formed by an inner stand and outer stand connected by releasable hinged connections to the back surface of the case housing. A track is formed on a surface of the outer stand that the inner stand slides along. A locking portion such as a cavity or channel on the outer stand locks the inner stand into an open position with respect to the outer stand. At least a portion of the outer stand is flexible such that applying a threshold pressure to the device case causes the portion of the outer stand to flex such that the locking portion releases the inner and outer stand from the open position without damaging the stand.

Abstract: The present invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof; as further described herein. The present invention further provides pharmaceutical compositions comprising these compounds, and combinations comprising these compounds combined with or used with a therapeutic co-agent, as well as therapeutic uses of these compounds and compositions. These are useful in the treatment of diseases such as cancer that are associated with activation of ERK1 and/or ERK2, and especially for MAPK pathway dependent cancers showing resistance to Raf and/or MEK inhibitory cancer therapeutics.

Abstract: A device case for a portable electronic device includes a device stand attached to a back surface of the case housing. The device stand is formed by an inner stand and outer stand connected by releasable hinged connections to the hack surface of the case housing. A track is formed on a surface of the outer stand that the inner stand glides along. A locking portion such as a cavity or channel on the outer stand locks the inner stand into an open position with respect to the outer stand. At least a portion of the outer stand is flexible such that applying a threshold pressure to the device case causes the portion of the outer stand to flex such that the locking portion releases the inner and outer stand from the open position without damaging the stand.