Patents by Inventor Daniel Raftery
Daniel Raftery has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10274496Abstract: A metabolic profiling approach for identifying biomarkers that provide highly sensitive and specific colorectal cancer (CRC) detection and monitoring using serum samples. The methods can be used for distinguishing CRC patients from both healthy controls and polyp patients, as well as to monitor disease progression or response to therapy. Receiver operator characteristic curves generated based on these models showed high sensitivities for differentiating CRC patients from healthy controls or polyp patients, good specificities, low false discovery rates, and excellent areas under the curve were obtained. Monte Carlo cross validation (MCCV) was also applied, demonstrating the robust diagnostic power of this metabolic profiling approach.Type: GrantFiled: January 16, 2015Date of Patent: April 30, 2019Assignee: UNIVERSITY OF WASHINGTONInventors: Daniel Raftery, Danijel Djukovic, Haiwei Gu, Jiangjiang Zhu
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Patent number: 9739780Abstract: Methods for the detection and screening of hepatocellular carcinoma (HCC) patients and for the monitoring of HCC treatment using a panel or panels of small molecule metabolite biomarkers are disclosed. In other aspects, methods for detection and screening for the progression of high-risk conditions, such as HCV infections, to HCC and to monitoring treatment using a panel or panels of small molecule metabolite biomarkers are disclosed. The biomarkers are sensitive and specific for the detection of HCC, and can also be used to classify HCV infections that are regarded as precursors of HCC.Type: GrantFiled: May 21, 2013Date of Patent: August 22, 2017Assignee: PURDUE RESEARCH FOUNDATIONInventors: Michael Daniel Raftery, Jeremiah Bowers, Siwei Wei, Hamid Reza Baniasadi
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Publication number: 20170097355Abstract: Methods for detecting and measuring metabolic changes useful in the detection of cancer, and in differentiating between ovarian cancer and benign ovarian tumor are described, as well as the unexpected and valuable combination of detecting both lipidomic and aqueous metabolites. Two independent LC-MS-based metabolomics platforms, including a global lipidomics approach, were used to screen for differentially abundant plasma metabolites between cases with serous ovarian carcinoma and controls with benign serous ovarian tumor. The identified biomarkers can be used to distinguish between ovarian cancer and benign tumors. Standards and kits for use with the methods for detecting cancer are also provided.Type: ApplicationFiled: October 6, 2016Publication date: April 6, 2017Applicant: UNIVERSITY OF WASHINGTONInventors: Daniel RAFTERY, Haiwei GU, Chris LI
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Publication number: 20170023575Abstract: The present disclosure relates to a panel of a plurality of metabolite species that is useful for the identification or detection of subjects having pancreatic cancer, including methods for identifying such metabolic biomarkers within biological samples. The disclosure also includes a statistical model for predicting the presence of pancreatic cancer in a subject's biofluid by quantifying and comparing positive and negative fold changes in metabolite species' concentration; comparing the subject's metabolite species' concentrations to a predetermined value.Type: ApplicationFiled: June 9, 2016Publication date: January 26, 2017Applicant: Purdue Research FoundationInventors: M. Daniel Raftery, Vincent Asiago, Kwadwo Owusu-sarfo, Bowei Xi
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Publication number: 20160363560Abstract: Methods for the detection and screening of esophageal adenocarcinoma (EAC) patients and for the monitoring of EAC treatment using a panel or panels of small molecule metabolite biomarkers are disclosed. In other aspects, methods for detection and screening for the progression of high-risk conditions (BE and HGD) to EAC and to monitoring treatment using a panel or panels of small molecule metabolite biomarkers are disclosed. The biomarkers are sensitive and specific for the detection of EAC, and can also be used to classify Barrett's esophagus (BE) and high-grade dysplasia (HGD), which are widely regarded as precursors of EAC.Type: ApplicationFiled: January 29, 2014Publication date: December 15, 2016Applicant: Purdue Research FoundationInventors: M. Daniel Raftery, Jian Zhang, Zane Hammoud
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Publication number: 20160341729Abstract: A metabolic profiling approach for identifying biomarkers that provide highly sensitive and specific colorectal cancer (CRC) detection and monitoring using serum samples. The methods can be used for distinguishing CRC patients from both healthy controls and polyp patients, as well as to monitor disease progression or response to therapy. Receiver operator characteristic curves generated based on these models showed high sensitivities for differentiating CRC patients from healthy controls or polyp patients, good specificities, low false discovery rates, and excellent areas under the curve were obtained. Monte Carlo cross validation (MCCV) was also applied, demonstrating the robust diagnostic power of this metabolic profiling approach.Type: ApplicationFiled: January 16, 2015Publication date: November 24, 2016Applicant: UNIVERSITY OF WASHINGTONInventors: Daniel Raftery, Danijel Djukovic, Haiwei Gu, Jiangjiang Zhu
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Publication number: 20160322210Abstract: Globally Optimized Targeted (GOT)-MS, combines many of the advantages of targeted detection and global profiling in metabolomics analysis, including the capability to detect unknowns, broad metabolite coverage, and excellent quantitation. A global search of precursor and product ions using a single triple quadrupole (QQQ) mass spectrometer includes SIM incremental scanning or incremental MS scanning performed in the mass range of 40-2000 Da, followed by tandem MS/MS scanning with incremental collision energy for precursor ions to profile product ions.Type: ApplicationFiled: April 27, 2016Publication date: November 3, 2016Applicant: UNIVERSITY OF WASHINGTONInventors: Daniel RAFTERY, Haiwei GU
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Publication number: 20150133331Abstract: Methods for the detection and screening of hepatocellular carcinoma (HCC) patients and for the monitoring of HCC treatment using a panel or panels of small molecule metabolite biomarkers are disclosed. In other aspects, methods for detection and screening for the progression of high-risk conditions, such as HCV infections, to HCC and to monitoring treatment using a panel or panels of small molecule metabolite biomarkers are disclosed. The biomarkers are sensitive and specific for the detection of HCC, and can also be used to classify HCV infections that are regarded as precursors of HCC.Type: ApplicationFiled: May 21, 2013Publication date: May 14, 2015Applicant: Purdue Research FoundationInventors: Michael Daniel Raftery, Jeremiah Bowers, Siwei Wei, Hamid Reza Baniasadi
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Publication number: 20150056605Abstract: The present disclosure relates to a panel of a plurality of metabolite species that is useful for the identification or detection of subjects having pancreatic cancer, including methods for identifying such metabolic biomarkers within biological samples. The disclosure also includes a statistical model for predicting the presence of pancreatic cancer in a subject's biofluid by quantifying and comparing positive and negative fold changes in metabolite species' concentration; comparing the subject's metabolite species' concentrations to a predetermined value.Type: ApplicationFiled: August 21, 2014Publication date: February 26, 2015Applicant: PURDUE RESEARCH FOUNDATIONInventors: M. Daniel Raftery, Vincent M. Asiago, Kwadwo Owusu-sarfo, Bowei Xi
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Publication number: 20140162903Abstract: The present disclosure relates to a panel of metabolite species that is useful for forecasting the outcome of preoperative chemotherapy for the treatment of breast cancer, including methods for identifying and using such metabolite species that can be measured in biological samples taken before treatment. In preferred embodiments, a method of forecasting a treatment outcome before subjecting a breast cancer patient to preoperative chemotherapy is disclosed that includes measuring the concentration of at least one metabolite species in a sample of a biofluid taken from the breast cancer patient before preoperative chemotherapy treatment.Type: ApplicationFiled: October 31, 2013Publication date: June 12, 2014Applicant: Purdue Research FoundationInventors: M. Daniel Raftery, Siwei Wei, Susan E. Clare
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Publication number: 20140148349Abstract: Methods for the detection and screening of esophageal adenocarcinoma (EAC) patients and for the monitoring of EAC treatment using a panel or panels of small molecule metabolite biomarkers are disclosed. In other aspects, methods for detection and screening for the progression of high-risk conditions (BE and HGD) to EAC and to monitoring treatment using a panel or panels of small molecule metabolite biomarkers are disclosed. The biomarkers are sensitive and specific for the detection of EAC, and can also be used to classify Barrett's esophagus (BE) and high-grade dysplasia (HGD), which are widely regarded as precursors of EAC.Type: ApplicationFiled: January 29, 2014Publication date: May 29, 2014Applicant: Purdue Research FoundationInventors: M. Daniel Raftery, Jian Zhang, Zane Hammoud
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Patent number: 8653006Abstract: Methods for the detection and screening of esophageal adenocarcinoma (EAC) patients and for the monitoring of EAC treatment using a panel or panels of small molecule metabolite biomarkers are disclosed. In other aspects, methods for detection and screening for the progression of high-risk conditions (BE and HGD) to EAC and to monitoring treatment using a panel or panels of small molecule metabolite biomarkers are disclosed. The biomarkers are sensitive and specific for the detection of EAC, and can also be used to classify Barrett's esophagus (BE) and high-grade dysplasia (HGD), which are widely regarded as precursors of EAC.Type: GrantFiled: September 6, 2011Date of Patent: February 18, 2014Assignee: Purdue Research FoundationInventors: M. Daniel Raftery, Jian Zhang, Zane Hammoud
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Publication number: 20130282300Abstract: A method for differentiating complex biological samples, each sample having one or more metabolite species. The method comprises producing a mass spectrum by subjecting the sample to a mass spectrometry analysis, the mass spectrum containing individual spectral peaks representative of the one or more metabolite species contained within the sample; subjecting the individual spectral peaks of the mass spectrum to a statistical pattern recognition analysis; identifying the one or more metabolite species contained within the sample by analyzing the individual spectral peaks of the mass spectrum; and assigning the sample into a defined sample class.Type: ApplicationFiled: June 14, 2013Publication date: October 24, 2013Inventors: M. Daniel Raftery, Huanwen Chen, Zhengzheng Pan
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Patent number: 8380445Abstract: A method for differentiating complex mixtures each having one or more chemical species is provided. The method comprises producing a sample NMR spectrum by subjecting a mixture to a selective spectroscopy process, wherein the NMR spectrum has individual spectral peaks representative of the one or more chemical species within the mixture. The one or more chemical species within the mixture are identified by analyzing the individual spectral peaks, and the individual spectral peaks are then subjected to a multivariate statistical analysis.Type: GrantFiled: March 2, 2011Date of Patent: February 19, 2013Assignee: Purdue Research FoundationInventors: Daniel Raftery, Peter Sandusky
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Publication number: 20120142542Abstract: Methods for the detection and screening of esophageal adenocarcinoma (EAC) patients and for the monitoring of EAC treatment using a panel or panels of small molecule metabolite biomarkers are disclosed. In other aspects, methods for detection and screening for the progression of high-risk conditions (BE and HOD) to EAC and to monitoring treatment using a panel or panels of small molecule metabolite biomarkers are disclosed. The biomarkers are sensitive and specific for the detection of EAC, and can also be used to classify Barrett's esophagus (BE) and high-grade dysplasia (HOD), which are widely regarded as precursors of EAC.Type: ApplicationFiled: September 6, 2011Publication date: June 7, 2012Applicant: Purdue Research FoundationInventors: M. Daniel Raftery, Jian Zhang, Zane Hammoud
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Publication number: 20120107955Abstract: Results of studies of nucleosides in biofluid specimens from patients with esophageal adenocarcinoma and related disorders have identified five biomarkers of the conditions: 1-methyladenosine, N2,N2-dimethylguanosine, N2-methylguanosine, cytidine and uridine. In certain embodiments, methods of measuring these biomarkers and kits for measuring these biomarkers are provided.Type: ApplicationFiled: September 6, 2011Publication date: May 3, 2012Applicant: Purdue Research FoundationInventors: M. Daniel Raftery, Danijel Djukovic, Zane Hammoud
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Publication number: 20110202285Abstract: A method for differentiating complex mixtures each having one or more chemical species is provided. The method comprises producing a sample NMR spectrum by subjecting a mixture to a selective spectroscopy process, wherein the NMR spectrum has individual spectral peaks representative of the one or more chemical species within the mixture. The one or more chemical species within the mixture are identified by analyzing the individual spectral peaks, and the individual spectral peaks are then subjected to a multivariate statistical analysis.Type: ApplicationFiled: March 2, 2011Publication date: August 18, 2011Applicant: PURDUE RESEARCH FOUNDATIONInventors: Daniel Raftery, Peter Sandusky
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Publication number: 20110123976Abstract: A method is provided for the parallel identification of one or more metabolite species within a biological sample. The method comprises analyzing the sample to produce a spectrum containing individual spectral peaks representative of the one or more metabolite species contained within the sample; subjecting each of the individual spectral peaks to a statistical pattern recognition analysis to identify the one or more metabolite species contained within the sample; and identifying the one or more metabolite species contained within the sample by analyzing the individual spectral peaks of the spectra.Type: ApplicationFiled: October 13, 2010Publication date: May 26, 2011Applicant: Purdue Research FoundationInventors: M. Daniel Raftery, Vincent Asiago
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Publication number: 20070221835Abstract: A method for differentiating complex biological samples, each sample having one or more metabolite species. The method comprises producing a mass spectrum by subjecting the sample to a mass spectrometry analysis, the mass spectrum containing individual spectral peaks representative of the one or more metabolite species contained within the sample; subjecting the individual spectral peaks of the mass spectrum to a statistical pattern recognition analysis; identifying the one or more metabolite species contained within the sample by analyzing the individual spectral peaks of the mass spectrum; and assigning the sample into a defined sample class.Type: ApplicationFiled: March 6, 2007Publication date: September 27, 2007Inventors: Daniel Raftery, Huanwen Chen, Zhengzheng Pan
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Publication number: 20070055456Abstract: A method for differentiating complex mixtures each having one or more chemical species is provided. The method comprises producing a sample NMR spectrum by subjecting a mixture to a selective spectroscopy process, wherein the NMR spectrum has individual spectral peaks representative of the one or more chemical species within the mixture. The one or more chemical species within the mixture are identified by analyzing the individual spectral peaks, and the individual spectral peaks are then subjected to a multivariate statistical analysis.Type: ApplicationFiled: August 31, 2006Publication date: March 8, 2007Inventors: Daniel Raftery, Peter Sandusky