Abstract: Techniques are disclosed relate to systems, methods, and non-transitory computer readable media for implementing a browser extension for cyber threat intelligence and response. One system to perform operations comprising: receiving, in a sandbox of a browser by a browser extension, a selection of at least one particular indicator of compromise of the at least one of the indicator of compromise of at least scanned part of a web page; displaying one or more orchestrated responses; receiving a selection of at least one particular orchestrated response of the one or more orchestrated responses; transmitting the selected at least one particular orchestrated response to the cloud-based enrichment and analysis of cybersecurity threat intelligence system; receiving a response including a result of the at least one particular orchestrated response; and displaying the result of the at least one particular orchestrated response.

Abstract: The present invention relates to novel substituted azetidine dihydrothienopyridines with phosphodiesterase inhibitory activity, and to their use in therapy, and to pharmaceutical compositions comprising the compounds and to methods of treating diseases with the compounds (I)

Abstract: Jet engine thermal transport bus pumps are disclosed. Disclosed herein is an aircraft comprising a gas turbine engine configured to burn fuel at a fuel flow rate to generate an engine power (Pengine), the fuel characterized by a first specific heat capacity (cp_fuel) and a net heat of combustion (NHCfuel); and a thermal management system configured to transfer heat from a working fluid to the fuel, the working fluid characterized by a second specific heat capacity (cp_pump) and a first density (?pump), the thermal management system including a pump configured to generate a pump power (Ppump) to pressurize the working fluid, and wherein P ? O ? W = P p ? u ? m ? p ( c p_pump c p_water ) ? ( ? w ? a ? t ? e ? r ? p ? u ? m ? p ) 2 , F ? F ? R = ( P e ? n ? g ? i ? n ? e N ? H ? C f ? u ? e ? l ) ? ( c p_fuel c p_pump ) 0.008?POW/FFR5/3?12, FFR is between 0.

Abstract: A computer game system including a game screen that has at least one game play element, and at least one human-only readable medium, such that the human-only readable medium displays information about the at least one game play element instructing a player how to successfully accomplish a game task, and a device and non-transitory computer-readable medium having instructions to run such a system.

Abstract: This invention relates to a synthetic method for the preparation of Compound 1 and precursors thereof. Compound 1 is prepared via reaction of isoxazole 2 with phenylether (R)-3-ONa.

Abstract: A hose assembly includes a hose, a connector body, and a collar. The connector body has an outer end portion defining a fluid connector, an inner end defining a nose portion received in an inner bore of the hose end portion, and an intermediate portion including first and second annular flanges spaced apart to define a dog lock groove. The collar includes an outer end portion defining an inner radial dog lock received in the dog lock groove, an annular step portion extending radially outward of and axially inward of the dog lock in axial alignment with the first annular flange, and an inner end portion extending radially outward of and axially inward from the step portion, the inner end portion being in radial compression against an outer surface of the hose end portion.

Abstract: Transgenic plants comprising synthetic protospacer adjacent motifs (sPAMs) or synthetic guide RNA recognition sites introduced at or near the junctions the transgene insert with non-transgenic genomic DNA, methods of making such plants, and use of such plants to facilitate breeding are disclosed.

Abstract: Methods of selectively excising polynucleotide segments including segments comprising non-essential DNA and/or selectable marker genes from transgenic loci from transgenic plants as well as making targeted genetic changes with genome editing techniques are provided. Also provided are transgenic plants comprising the transgenic loci lacking the non-essential DNA and/or selectable markers and use of such methods and plants to facilitate plant breeding are disclosed.

Abstract: Transgenic INHT31 soybean plants comprising modifications of the MON89788 soybean locus which provide for facile excision of the modified MON89788 transgenic locus or portions thereof, methods of making such plants, and use of such plants to facilitate breeding are disclosed.

Abstract: A system integrating disparate emergency response capabilities within a facility including a sensor assembly comprising a plurality of sensors disposed in predetermined locations throughout the facility, wherein different ones of said plurality of sensors are determinative of different emergency conditions such as, but not limited to, fire, smoke, active shooter emergencies, etc. A display assembly comprises a plurality of displays located in different facility areas (rooms, offices, stores, etc.) as well as along pathways, defining escape routes, between each of the plurality of facility areas and an appropriate facility exit. A database, including software programing is responsive to said sensor assembly and operative to generate messaging to said plurality of displays, wherein the messaging includes variable responsive content, including evacuation mapping or lockdown instructions, dependent on detected emergency conditions (fire, active shooter, etc.).

Abstract: Transgenic INHT31 soybean plants comprising modifications of the MON89788 soybean locus which provide for facile excision of the modified MON89788 transgenic locus or portions thereof, methods of making such plants, and use of such plants to facilitate breeding are disclosed.

Abstract: Methods of selectively excising transgenic loci from transgenic plants and use of such methods to facilitate plant breeding are disclosed.

Abstract: Transgenic INHT26 soybean plants comprising modifications of the DAS44406-6 soybean locus which provide for facile excision of the modified DAS44406-6 transgenic locus or portions thereof, methods of making such plants, and use of such plants to facilitate breeding are disclosed.

Abstract: Transgenic INHT26 soybean plants comprising modifications of the DAS44406-6 soybean locus which provide for facile excision of the modified DAS44406-6 transgenic locus or portions thereof, methods of making such plants, and use of such plants to facilitate breeding are disclosed.

Abstract: Implementations describe systems and methods for manufacturing and performing quality assessment of dental appliances. In one embodiment, a method of manufacturing a dental appliance comprises receiving, at a holder, a feature of the dental appliance, the feature comprising a first surface having a first shape, wherein the holder holds the feature of the dental appliance at a reference position. The method further includes automatically placing an object against the feature at the reference position using a robot arm, wherein the object comprises a second surface having a second shape that mates with the first shape. The method further includes applying pressure to press the object against the feature of the dental appliance and bonding the object to the feature of the dental appliance while applying the pressure.

Abstract: Disclosed are methods of obtaining clonal seeds, methods of plant cloning, methods of screening for maternal plants that produce clonal seeds asexually and methods of increasing yield of clonal seeds. Also disclosed are constructs comprising a nucleic acid that may silence the activity of a RNA-dependent DNA methylation pathway gene. Further disclosed are maternal plants comprising a construct wherein the construct comprises an exogenous nucleic acid sequence, wherein the construct renders the maternal plant defective for RNA-dependent DNA methylation.

Abstract: The present invention relates to novel substituted azetidine dihydrothienopyridines with phosphodiesterase inhibitory activity, and to their use in therapy, and to pharmaceutical compositions comprising the compounds and to methods of treating diseases with the compounds (I)

Abstract: The present invention is related to the field of liquid disinfectant formulas, specifically with obtaining disinfectant compositions applicable to hard and smooth surfaces, porous surfaces and for human use; particularly with disinfectant compositions that allow the surface or surfaces where it is applied, a disinfection with a prolonged effect, for periods greater than 24 hours. More particularly with the use of long-lasting disinfectant compounds, some of them approved by international agencies such as the EPA, and which are also approved by the FDA for cosmetic use due to their low or null toxicity. More particularly, the present invention relates to the formulation of said compositions.

Abstract: Disclosed herein are compositions, devices, methods, processes, and systems for culturing of large quantities of mammalian cells in suspension culture. Also disclosed are unique and surprising cell populations derived from the disclosed methods, processes, and systems. In many embodiments, the cells are cultured in suspension in liquid culture media that is agitated to maintain the cells in suspension, and agitation increases to maintain cells in suspension while growing and dividing to create cell spheres. The disclosed devices, methods, processes, and systems are useful in tailoring characteristics of the resulting cells based on characteristics of donor subject/initial cells. The disclosed cell populations are useful in treating subjects with cell based therapies in need thereof for various diseases and conditions.

Abstract: Transgenic INIR12 maize plants comprising a vip3Aa19 or vip3Aa20 expression cassette linked to a secondary nopaline synthase terminator element which lack a selectable marker gene and/or which comprise modifications that provide for facile excision of the INIR12 transgenic locus from the maize plant genome are provided. Genomic DNA of INIR12 transgenic plants, detection of INIR12 plants and products thereof, methods of making INIR12 plants, and use of INIR12 plants to facilitate breeding are disclosed.