Abstract: The present invention relates to the use of receptor tyrosine kinase (RTK) oligomers as markers of RTK activation and signalling. Methods are described based upon determining the presence of RTK oligomers and/or determining the nanometre spatial separation between RTK molecules assembled as RTK oligomers at the cell surface. Such methods are directed to the monitoring of RTK activation in cells and the detection of mutations in RTKs. Methods are also described for determining prognosis for subjects having diseases characterised by aberrant RTK activation and for selecting subjects for treatment with RTK inhibitors.

Abstract: The present invention relates to the use of receptor tyrosine kinase (RTK) oligomers as markers of RTK activation and signalling. Methods are described based upon determining the presence of RTK oligomers and/or determining the nanometre spatial separation between RTK molecules assembled as RTK oligomers at the cell surface. Such methods are directed to the monitoring of RTK activation in cells and the detection of mutations in RTKs. Methods are also described for determining prognosis for subjects having diseases characterised by aberrant RTK activation and for selecting subjects for treatment with RTK inhibitors.

Abstract: The present invention relates to the use of receptor tyrosine kinase (RTK) oligomers as markers of RTK activation and signalling. Methods are described based upon determining the presence of RTK oligomers and/or determining the nanometre spatial separation between RTK molecules assembled as RTK oligomers at the cell surface. Such methods are directed to the monitoring of RTK activation in cells and the detection of mutations in RTKs. Methods are also described for determining prognosis for subjects having diseases characterised by aberrant RTK activation and for selecting subjects for treatment with RTK inhibitors.

Abstract: When a loading bridge is connected to a small aircraft to allow passengers to board or deplane, a large size difference exists between the aperture of a loading bridge and the entry/exit hatch of a small aircraft; the loading bridge aperture being larger than the aircraft hatch. Accordingly, the size difference creates a potentially dangerous gap. The extensible platform on an extensible passenger loading bridge is for alleviating the gap and as such for providing a safe pathway to passengers when they board or deplane.

Abstract: A passenger loading bridge is disclosed. In particular an extensible loading bridge having at least two extensible sections for supporting aircraft from an airport terminal at ground level. A wheeled gantry is located at the aircraft facing end of the aircraft facing section. The gantry provides linear movement of the aircraft facing section along the walkway, arcuate movement about the substantially vertical axis and means for lifting or lowering the aircraft facing end of the aircraft facing section. The wheeled gantry allows lowering of the aircraft facing end of the bottom of the aircraft facing section to a height above ground being approximately equal or less than a gantry wheel diameter.

Abstract: An extensible loading bridge for passenger loading having at least two extensible sections for supporting aircraft from an airport terminal at ground level. A wheeled gantry is located at the aircraft facing end of the aircraft facing section. The gantry provides linear movement of the aircraft facing section along the walkway, arcuate movement about the substantially vertical axis and means for lifting or lowering the aircraft facing end of the aircraft facing section. The wheeled gantry allows lowering of the aircraft facing end of the bottom of the aircraft facing section to a height above ground being approximately equal or less than a gantry wheel diameter.

Abstract: An extensible platform on an extensible passenger loading bridge is disclosed in the present invention. When a loading bridge is connected to a small aircraft to allow passengers to board or deplane, a large size difference exists between the aperture of a loading bridge and the entry/exit hatch of a small aircraft; the loading bridge aperture being larger than the aircraft hatch. Accordingly, the size difference creates a potentially dangerous gap. The extensible platform on an extensible passenger loading bridge is for alleviating the gap and as such for providing a safe pathway to passengers when they board or deplane.