Abstract: Novel selective estrogen receptor degraders (SERDs) according to the formula: pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, wherein either R1 or R2 is independently selected from Cl, F, —CF3, or —CH3, and the other is hydrogen, and methods for their use are provided.

Abstract: The present disclosure provides an aerosol unit for an aerosol dispenser. The aerosol unit includes an axially oriented body, having a distal inlet part and a proximal outlet part. The aerosol unit also includes a carrier member arranged in the body, transversally to the axis between the inlet part and the outlet part. The carrier member includes through-holes which place the inlet part in fluid communication with the outlet part, and the carrier member is insert-moulded into the body such that a contact surface between the carrier and the body forms an air-tight seal.

Abstract: A locking mechanism for an aerosol dispenser is presented having a first body structure, a second body structure rotatably attached to the first body structure, a spindle rotatably attached to the second body structure, the spindle having an actuator rotationally cooperating with the first body structure such that rotation of the first body structure relative to the second body structure causes rotation of the actuator and of the spindle, a movable element arranged around the spindle, the spindle being rotatable relative to the movable element, wherein rotation of the spindle causes movement of the movable element along the spindle from an initial position to a final position, and a locking element, wherein in the final position the movable element applies a radial force onto the locking element causing the locking element to bend in the radial direction thereby preventing rotation between the first body structure and the second body structure.

Abstract: A dose counting mechanism for an aerosol dispenser is presented where the dose counting mechanism has a first body structure, a second body structure rotatably attached to the first body structure, an annular dose counter provided with a plurality of teeth along its perimeter, the dose counter being arranged coaxially with the first body structure and the second body structure, each of the first body structure and the second body structure being rotatable relative to the dose counter, a rotatable actuator that meshes with the teeth of the dose counter, the actuator being configured to follow the perimeter of the dose counter when the second body structure is rotated relative to the first body structure, and a rotator that rotates concurrently with one of the first body structure and the second body structure and that engages with the actuator when rotation of the first body structure relative to the second body structure is initiated.

Abstract: An activation mechanism for an aerosol dispenser is presented having a first housing structure, an actuation member movably arranged in the first housing structure, wherein the first housing structure is provided with an actuation member opening in level with the axial position of the actuation member, and an activation member slidably attached to the first housing structure, the activation member slides between a non-triggering position and a triggering position relative to the first housing structure, wherein the activation member has a radially flexible tab portion that is offset from the actuation member opening when the activation member is in the non-triggering position, restricting radial flexing of the tab portion, and wherein the tab portion aligns with the actuation member opening when the activation member is in the triggering position, thereby enabling the tab portion to flex radially inwards to cause movement of the actuation member.

Abstract: This application describes syringe carriers for medicament delivery devices such as autoinjectors. In particular, an example syringe carrier is tubular and extends along a longitudinal axis from a proximal end to a distal end, the syringe carrier comprising a base section at the distal end of the syringe carrier, the base section having a fixed circumference, at least one arm extending towards the proximal end of the syringe carrier from the base section, and an expandable ring attached to the proximal end of the at least one arm, wherein the ring extends entirely around the longitudinal axis of the syringe carrier in the circumferential direction. Various other syringe carriers and associated medicament delivery devices and methods are described.

Abstract: A mechanism for receiving an injector having a needle and a compressible body for driving expulsion of medicament through the needle, the mechanism having an actuating element configured to transition from a ready state to a dosing state by means of manual manipulation; a pressing device arranged to move from a starting position to a pressing position to thereby press the compressible body when the injector is received by the mechanism; and a force transmission arrangement configured to transmit a transition of the actuating element from the ready state to the dosing state to a movement of the pressing device from the starting position to the pressing position. A medicament delivery device comprising the injector and a mechanism is also provided.

Abstract: The present invention relates to a recording unit arranged to be connected to a medicament delivery device, which recording unit comprises a generally elongated housing having dimensions so as to enclose at least a distal part of the medicament delivery device, the recording unit comprising a recording mechanism provided with an electronic circuit and arranged at a distal end inside said housing, said electronic circuit comprising an activation element operably arranged to activate said electronic circuit when said medicament delivery device is inserted in said housing, said electronic circuit comprising sensor elements capable of sensing status changes of said medicament delivery device during use.

Abstract: The present disclosure relates to a device for handling medicament delivery devices and is to be used with a safety container, where the medicament delivery devices have information retaining elements having information that is unique to specific medicament delivery devices, and which medicament delivery devices are to be put in a safety container after use. The disclosed device has an information obtaining mechanism operably arranged to obtain information from the medicament delivery devices placed into the safety container.

Abstract: An automatic feedback mechanism for a medicament delivery device that notifies a user of a start of expulsion of medicament from a medicament container is presented where a plunger rod, a tubular extension member arranged to receive the plunger rod in the radial space, and wherein the tubular extension member has flexible tongues configured to releasably lock the plunger rod in a pre-tensioned state. The tubular operation member is arranged to receive the tubular extension member, where the tubular operation member in a first position is arranged to press the flexible tongues radially inwards to lock the plunger rod in the pre-tensioned state. A first resilient member is arranged inside the plunger rod to exert a force in the proximal direction. A signal generating member is arranged to partially surround the plunger rod such that movement of the signal generating member distally hits the inner distal surface generating an audible signal.

Abstract: A medicament delivery device is presented having a housing that is arranged to accommodate a medicament container, a drive unit operably arranged to act on the medicament container upon activation, an activation mechanism operably arranged to be operated by a user, an activation preventing mechanism operably arranged to prevent the activation mechanism to be activated, an usage management module arranged to be operated by a user, which usage management module is designed as an attachable unit to the medicament delivery device. First keying elements are arranged on the device and on the usage management module designed to interact with each other when attaching said usage management module, such as to cause a deactivation of the activation preventing mechanism to allow operation of the activation mechanism. The usage management module can include a monitoring circuit arranged to monitor the use of the medicament delivery device.

Abstract: The present disclosure relates to a device for handling medicament delivery devices and is to be used with a safety container, where the medicament delivery devices have information retaining elements having information that is unique to specific medicament delivery devices, and which medicament delivery devices are to be put in a safety container after use. The disclosed device has an information obtaining mechanism operably arranged to obtain information from the medicament delivery devices placed into the safety container.

Abstract: The present disclosure relates to an activation system for a supplemental device that is attached to an existing design of a medicament delivery device, where the removal of a protective cap or other covering from the medicament delivery device pulls a blocking element from between electrical contacts to close a circuit between a battery module and a power source, thus activating the battery module. The supplemental device can further have a transmitter for communicating information about the use of the medicament delivery device to an external device, such as a smart device. Memory storage elements can also be included having unique identification data. The present disclosure also relates to a medicament delivery device having attached the supplemental device.

Abstract: An aerosol assembly for a medicament delivery device is provided having a nozzle chip assembly including a carrier and a nozzle chip provided on the carrier, a holding structure having a fluid channel extending through the holding structure, wherein the nozzle chip assembly is configured to be mounted into the fluid channel such that fluid flowing through the fluid channel passes through the nozzle chip, and an elastic sealing member configured to be arranged with a tight fit in the fluid channel, the sealing member having a central through-opening configured to receive the nozzle chip to seal the nozzle chip towards the carrier.

Abstract: A medicament delivery device is presented having a housing that is arranged to accommodate a medicament container, a drive unit operably arranged to act on the medicament container upon activation, an activation mechanism operably arranged to be operated by a user, an activation preventing mechanism operably arranged to prevent the activation mechanism to be activated, an usage management module arranged to be operated by a user, which usage management module is designed as an attachable unit to the medicament delivery device. First keying elements are arranged on the device and on the usage management module designed to interact with each other when attaching said usage management module, such as to cause a deactivation of the activation preventing mechanism to allow operation of the activation mechanism. The usage management module can include a monitoring circuit arranged to monitor the use of the medicament delivery device.

Abstract: A spray nozzle chip is presented having a substrate with a spray side and a sieve side, a spray membrane provided on the spray side, a sieve membrane provided on the sieve side, wherein the spray membrane is provided with spray orifices and the sieve membrane is provided with sieve orifices, wherein the substrate has a fluid channel which connects the spray orifices with the sieve orifices, and a pressure sensing device configured to measure deformation of the spray membrane to obtain a measure of pressure on the spray membrane.

Abstract: An aerosol generator for an aerosol dispenser is presented where, the aerosol generator has a housing having an inlet part comprising a liquid inlet configured to guide a liquid jet (L) into the housing and an air inlet configured to guide an air flow into the housing. The housing further having an outlet part having an aerosol outlet configured to guide an aerosol (C) of liquid mixed with air out of the housing. The air inlet is configured such that at least part of the air flow entering the housing through the air inlet is obstructed at a distance from the liquid jet (L) entering the housing through the liquid inlet, thereby creating a source of turbulence in the housing to interact with droplets of the liquid jet (L) to prevent coalescence of the droplets.

Abstract: An electrical information device configured to communicate information related to a medicament delivery performed by a medicament delivery device is presented. The device includes at least one information communication unit configured to communicate the information, and at least one power providing arrangement including at least one power source, at least one electrical switch and at least one switch lock member. The at least one switch lock member being configured to be movable in an axial direction from a first position to a second position by an axial movement of at least one triggering member of the medicament delivery device, to cause a change of state of the at least one electrical switch in the second position, thereby providing electrical power to the at least one information communication unit from the at least one power source, and to be locked in the second position, such that the change of state of the electrical switch is maintained.

Abstract: The present invention relates to a medicament delivery device comprising a housing (10), which housing is arranged to accommodate a medicament container (20); a power unit (88) comprising: a drive force element (98), an actuation unit (90, 102) operably connected to said drive force element (98); which actuation unit (90, 102) is movable, upon activation of said drive force element (98), for expelling a dose of medicament from said medicament container (20); a monitoring unit (130) provided with an electrical power source (140) for operating said monitoring unit (130). The invention is characterised in that the medicament delivery device further comprises an activation element (160) operably connected to said actuation unit (90, 102), to said monitoring unit (130) and to said electrical power source (140), wherein said activation element (160) is arranged to allow connection between said electrical power source (140) and said monitoring unit (130) when said actuation unit (98, 102) is moved.

Abstract: A medicament delivery device is presented having a housing that is arranged to accommodate a medicament container, a drive mechanism capable of, upon activation, act on said medicament container, a communication unit arranged in the housing, a switch operably connectable to the drive mechanism and connected to the communication unit for activating the communication unit when the switch is operated, wherein the switch is operated by the drive mechanism at the end of a dose delivery sequence.