Patents by Inventor Daniel Tod Smithey

Daniel Tod Smithey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutical compositions of amorphous dispersions of drugs and lipophilic microphase-forming materials
    Patent number: 10357455
    Abstract: A pharmaceutical composition comprises a solid amorphous dispersion comprising a low-solubility drug and a concentration-enhancing polymer and a lipophilic microphase-forming material. Alternatively, a solid amorphous dispersion comprising a low-solubility drug and a concentration-enhancing polymer is co-administered with a lipophilic microphase-forming material to an in vivo use environment.
    Type: Grant
    Filed: July 27, 2018
    Date of Patent: July 23, 2019
    Assignee: Bend Research, Inc.
    Inventors: Michael E. Perlman, Ravi M. Shanker, Walter C. Babcock, Dwayne Thomas Friesen, Mark D. Rabenstein, Daniel Tod Smithey
  • PHARMACEUTICAL COMPOSITIONS OF AMORPHOUS DISPERSIONS OF DRUGS AND LIPOPHILIC MICROPHASE-FORMING MATERIALS
    Publication number: 20180338915
    Abstract: A pharmaceutical composition comprises a solid amorphous dispersion comprising a low-solubility drug and a concentration-enhancing polymer and a lipophilic microphase-forming material. Alternatively, a solid amorphous dispersion comprising a low-solubility drug and a concentration-enhancing polymer is co-administered with a lipophilic microphase-forming material to an in vivo use environment.
    Type: Application
    Filed: July 27, 2018
    Publication date: November 29, 2018
    Applicant: Bend Research, Inc.
    Inventors: Michael E. Perlman, Ravi M. Shanker, Walter C. Babcock, Dwayne Thomas Friesen, Mark D. Rabenstein, Daniel Tod Smithey
  • PHARMACEUTICAL COMPOSITIONS OF AMORPHOUS DISPERSIONS OF DRUGS AND LIPOPHILIC MICROPHASE-FORMING MATERIALS
    Publication number: 20170000733
    Abstract: A pharmaceutical composition comprises a solid amorphous dispersion comprising a low-solubility drug and a concentration-enhancing polymer and a lipophilic microphase-forming material. Alternatively, a solid amorphous dispersion comprising a low-solubility drug and a concentration-enhancing polymer is co-administered with a lipophilic microphase-forming material to an in vivo use environment.
    Type: Application
    Filed: September 16, 2016
    Publication date: January 5, 2017
    Applicant: Bend Research, Inc.
    Inventors: Michael E. Perlman, Ravi M. Shanker, Walter C. Babcock, Dwayne Thomas Friesen, Mark D. Rabenstein, Daniel Tod Smithey
  • Nanoparticles comprising a non-ionizable cellulosic polymer and an amphiphilic non-ionizable block copolymer
    Patent number: 8974827
    Abstract: A pharmaceutical composition comprises nanoparticles comprising a poorly water-soluble drug, a poorly aqueous soluble non-ionizable cellulosic polymer, and a poorly aqueous soluble polymeric amphiphilic non-ionizable block copolymer.
    Type: Grant
    Filed: May 26, 2008
    Date of Patent: March 10, 2015
    Assignee: Bend Research, Inc.
    Inventors: Corey Jay Bloom, Marshall David Crew, Warren Kenyon Miller, Michael Mark Morgen, Daniel Tod Smithey
  • Solid compositions of low-solubility drugs and poloxamers
    Patent number: 8974823
    Abstract: Solid compositions of low-solubility drugs and poloxamers that provide concentration enhancement when administered to an aqueous environment of use are disclosed.
    Type: Grant
    Filed: December 20, 2004
    Date of Patent: March 10, 2015
    Assignee: Bend Research, Inc.
    Inventors: Daniel Tod Smithey, Dwayne Thomas Friesen, Warren Kenyon Miller, Walter Christian Babcock
  • Pharmaceutical compositions with enhanced performance
    Patent number: 8940800
    Abstract: Disclosed are polymers of hydroxypropyl methyl cellulose acetate succinate (HPMCAS) and hydroxypropyl methyl cellulose acetate (HPMCA) with unique degrees of substitution of hydroxypropoxy, methoxy, acetyl, and succinoyl groups. When used in making compositions comprising a low-solubility drug and such polymers, the polymers provide enhanced aqueous concentrations and/or improved physical stability.
    Type: Grant
    Filed: June 26, 2012
    Date of Patent: January 27, 2015
    Assignee: Bend Research, Inc.
    Inventors: Walter C. Babcock, Dwayne T. Friesen, David Keith Lyon, Warren Kenyon Miller, Daniel Tod Smithey
  • Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and anon-ionizable polymer
    Patent number: 8703204
    Abstract: A pharmaceutical composition comprises nanoparticles comprising a cholesteryl ester transfer protein inhibitor and a poorly aqueous soluble non-ionizable polymer.
    Type: Grant
    Filed: April 23, 2008
    Date of Patent: April 22, 2014
    Assignee: Bend Research, Inc.
    Inventors: Corey Jay Bloom, Marshall David Crew, Daniel Tod Smithey, Warren Kenyon Miller, Michael Mark Morgen
  • Pharmaceutical compositions with enhanced performance
    Patent number: 8617604
    Abstract: Pharmaceutical compositions of a low-solubility drug and lower alkanoate-, phthalate- and trimellitate esters of hydroxypropyl methyl cellulose and lower alkanoate- and succinate esters of cellulose and methyl cellulose are disclosed that provide enhanced concentrations of the drug in a use environment.
    Type: Grant
    Filed: January 23, 2006
    Date of Patent: December 31, 2013
    Assignee: Bend Research, Inc.
    Inventors: Walter Christian Babcock, Dwayne Thomas Friesen, David Kenneth Lyon, Warren Kenyon Miller, Daniel Tod Smithey
  • Nanoparticles comprising a drug, ethylcellulose, and a bile salt
    Patent number: 8309129
    Abstract: A pharmaceutical composition comprises nanoparticles comprising a poorly water-soluble drug, ethylcellulose, and a bile salt.
    Type: Grant
    Filed: April 21, 2008
    Date of Patent: November 13, 2012
    Assignee: Bend Research, Inc.
    Inventors: Warren Kenyon Miller, Michael Mark Morgen, Daniel Tod Smithey
  • PHARMACEUTICAL COMPOSITIONS WITH ENHANCED PERFORMANCE
    Publication number: 20120264833
    Abstract: Disclosed are polymers of hydroxypropyl methyl cellulose acetate succinate (HPMCAS) and hydroxypropyl methyl cellulose acetate (HPMCA) with unique degrees of substitution of hydroxypropoxy, methoxy, acetyl, and succinoyl groups. When used in making compositions comprising a low-solubility drug and such polymers, the polymers provide enhanced aqueous concentrations and/or improved physical stability.
    Type: Application
    Filed: June 26, 2012
    Publication date: October 18, 2012
    Inventors: Walter C. Babcock, Dwayne T. Friesen, David Keith Lyon, Warren Kenyon Miller, Daniel Tod Smithey
  • Pharmaceutical compositions with enhanced performance
    Patent number: 8207232
    Abstract: Disclosed are polymers of hydroxypropyl methyl cellulose acetate succinate (HPMCAS) and hydroxypropyl methyl cellulose acetate (HPMCA) with unique degrees of substitution of hydroxypropoxy, methoxy, acetyl, and succinoyl groups. When used in making compositions comprising a low-solubility drug and such polymers, the polymers provide enhanced aqueous concentrations and/or improved physical stability.
    Type: Grant
    Filed: May 18, 2005
    Date of Patent: June 26, 2012
    Assignee: Bend Research, Inc.
    Inventors: Walter C. Babcock, Dwayne T. Friesen, David Keith Lyon, Warren Kenyon Miller, Daniel Tod Smithey
  • NANOPARTICLES COMPRISING A NON-IONIZABLE CELLULOSIC POLYMER AND AN AMPHIPHILIC NON-IONIZABLE BLOCK COPOLYMER
    Publication number: 20100323014
    Abstract: A pharmaceutical composition comprises nanoparticles comprising a poorly water-soluble drug, a poorly aqueous soluble non-ionizable cellulosic polymer, and a poorly aqueous soluble polymeric amphiphilic non-ionizable block copolymer.
    Type: Application
    Filed: May 26, 2008
    Publication date: December 23, 2010
    Inventors: Corey Jay Bloom, Marshall David Crew, Warren Kenyon Miller, Michael Mark Morgen, Daniel Tod Smithey
  • NANOPARTICLES COMPRISING A NON-IONIZABLE POLYMER AND AN ANIONIC CELLULOSIC POLYMER
    Publication number: 20100266692
    Abstract: A pharmaceutical composition comprises nanoparticles comprising a poorly water soluble drug, a poorly aqueous soluble non-ionizable polymer, and an anionic cellulosic polymer.
    Type: Application
    Filed: June 30, 2008
    Publication date: October 21, 2010
    Inventors: Corey Jay Bloom, Marshall David Crew, Warren Kenyon Miller, Daniel Tod Smithey
  • NANOPARTICLES COMPRISING IONIZABLE, POORLY WATER SOLUBLE CELLULOSIC POLYMERS
    Publication number: 20100215747
    Abstract: A pharmaceutical composition comprises nanoparticles comprising ionizable, poorly water soluble cellulosic polymers.
    Type: Application
    Filed: June 30, 2008
    Publication date: August 26, 2010
    Inventors: Corey Jay Bloom, Marshall David Crew, Dwayne T. Friesen, Warren Kenyon Miller, Michael Mark Morgen, Daniel Tod Smithey
  • NANOPARTICLES COMPRISING A CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITOR AND ANON-IONIZABLE POLYMER
    Publication number: 20100129447
    Abstract: A pharmaceutical composition comprises nanoparticles comprising a cholesteryl ester transfer protein inhibitor and a poorly aqueous soluble non-ionizable polymer.
    Type: Application
    Filed: April 23, 2008
    Publication date: May 27, 2010
    Inventors: Corey Jay Bloom, Marshall David Crew, Daniel Tod Smithey, Warren Kenyon Miller, Michael Mark Morgen
  • NANOPARTICLES COMPRISING NON-CRYSTALLINE DRUG
    Publication number: 20100119612
    Abstract: A pharmaceutical composition comprises nanoparticles comprising a core of non-crystalline drug and surface stabilizers consisting of a phospholipid and a bile salt.
    Type: Application
    Filed: April 7, 2008
    Publication date: May 13, 2010
    Inventors: Dwayne Thomas Friesen, Daniel Tod Smithey, Michael Mark Morgen, Ralph Tadday
  • NANOPARTICLES COMPRISING A DRUG,ETHYCELLULOSE,AND A BILE SALT
    Publication number: 20100119603
    Abstract: A pharmaceutical composition comprises nanoparticles comprising a poorly water-soluble drug, ethylcellulose, and a bile salt.
    Type: Application
    Filed: April 21, 2008
    Publication date: May 13, 2010
    Inventors: warren Kenyon Miller, Michael Mark Morgen, Daniel Tod Smithey
  • PHARMACEUTICAL COMPOSITIONS COMPRISING NANOPARTICLES COMPRISING ENTERIC POLYMERS CASEIN
    Publication number: 20100062073
    Abstract: A pharmaceutical composition comprises nanoparticles comprising a poorly water-soluble drug and an enteric polymer, and casein.
    Type: Application
    Filed: November 16, 2007
    Publication date: March 11, 2010
    Inventors: Ronald Arthur Beyerinck, Corey Jay Bloom, Marshall David Crew, Dwayne Thomas Friesen, Michael Mark Morgen, Daniel Tod Smithey
  • SUSTAINED RELEASE DOSAGE FORMS OF ZIPRASIDONE
    Publication number: 20100003331
    Abstract: A sustained release solid oral dosage form for treatment of a psychotic disorder, for example schizophrenia, in a mammal is provided, which oral dosage form comprises ziprasidone in an amount effective in treating said psychotic disorder and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: September 3, 2009
    Publication date: January 7, 2010
    Applicant: Pfizer Inc.
    Inventors: Imran Ahmed, Leah Elizabeth Appel, Walter Christian Babcock, Dwayne Thomas Friesen, Scott Herbig, David Keith Lyon, Sheri L. Shamblin, Ravi Mysore Shanker, Daniel Tod Smithey, Steven C. Sutton, Avinash Govind Thombre, Kenneth C. Waterman, Jaymin C. Shah, Parag Suresh Shah, Peter Wisniecki, Dawn Renee Wagner
  • Solid Adsorbates of Hydrophobic Drugs
    Publication number: 20090169583
    Abstract: A solid pharmaceutical composition comprises a solid adsorbate comprising a hydrophobic drug, a lipophilic vehicle, and a porous substrate, wherein the hydrophobic drug and lipophilic vehicle are adsorbed to the porous substrate.
    Type: Application
    Filed: January 30, 2006
    Publication date: July 2, 2009
    Inventors: Timothy James Brodeur, Daniel Tod Smithey, Ralph Tadday