Abstract: Compounds of Formula I that inhibit the activity of the diacylglycerol acyltransferase 2 (DGAT2) and their uses in the treatment of diseases linked thereto in animals are described herein.

Abstract: Techniques and systems for operating a video ad exchange includes controlling an ad server to receive ad requests from viewer devices, provide ad responses to viewer devices, generate an ad delivery data file that includes information about delivery of ads to the viewer devices, and transfer the ad delivery data file to a distributed computing cloud. The technique further includes controlling an ad data infrastructure mechanism to download the cloud-based ad delivery data file into a local memory, and process the copied ad delivery data file to generate billing data. An ad data infrastructure mechanism receives a configuration file from the ad server, verifies that all items in the configuration file from the ad server were used in the generation of the first billing data, and removes non-verifiable items from the first billing data to generate a final billing data.

Abstract: Compounds of Formula I that inhibit the activity of the diacylglycerol acyltransferase 2 (DGAT2) and their uses in the treatment of diseases linked thereto in animals are described herein.

Abstract: Myeloperoxidase inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, cardiovascular conditions.

Abstract: The present invention relates to indole and indazole compounds of Formula (I) that activate 5? adenosine monophosphate-activated protein kinase (AMPK). The invention also encompasses pharmaceutical compositions containing these compounds and methods for treating or preventing diseases, conditions, or disorders ameliorated by activation of AMPK.

Abstract: A process is provided for preparing a defined starting operation of a motor vehicle selectable by the driver, having a starting element arranged between an engine and a transmission. In the event of a maximal power demand by the driver and in the event of the selection of the defined starting operation by an electronic control unit, the rotational speed or the torque of the engine is set to a specified value, wherein the specified value is automatically determined by the electronic control unit as function of a determined friction parameter, by which at least one relative prediction concerning the transmissible drive torque to be expected for the acceleration operation can be made, such that, by use of the specified during the starting and acceleration operation following the preparation, the maximally possible drive torque is achieved for the best possible acceleration.

Abstract: Systems and methods for reducing accuracy of web bugs are disclosed. In some implementations, a method includes, at a computing device, identifying an incoming electronic message addressed to an intended recipient. The incoming electronic message includes a plurality of content items provided by a content provider. The method also includes, before the intended recipient reviews the incoming electronic message, reducing accuracy of user activity tracking by the content provider, by: requesting on a modeled temporal basis, a download of a first media content item in the plurality of media content items. In some implementations, the first media content item is invisible to the intended recipient.

Abstract: Systems and methods for reducing accuracy of web bugs are disclosed. In some implementations, a method includes, at a computing device, identifying an incoming electronic message addressed to an intended recipient. The incoming electronic message includes a plurality of content items provided by a content provider. The method also includes, before the intended recipient reviews the incoming electronic message, reducing accuracy of user activity tracking by the content provider, by: requesting on a modeled temporal basis, a download of a first media content item in the plurality of media content items. In some implementations, the first media content item is invisible to the intended recipient.

Abstract: The present invention relates to indole and indazole compounds of Formula (I) that activate 5? adenosine monophosphate-activated protein kinase (AMPK). The invention also encompasses pharmaceutical compositions containing these compounds and methods for treating or preventing diseases, conditions, or disorders ameliorated by activation of AMPK.

Abstract: A urinary catheter system includes a catheter, a sheath, an enclosure and a plug. The catheter has distal and proximal ends. The sheath is slidable along the catheter between first and second positions. The enclosure encloses a majority of the catheter and includes a bottom member, a top member, an outer peripheral wall defining an outer hole to allow advancement of the distal end, and an inner peripheral wall defining an inner hole, where the catheter is extendable through the inner hole. Rotating the top or bottom member relative to the other member causes the catheter to wind within the enclosure. The plug can seal the proximal end to block liquid flow, and a user can disengage the plug to allow liquid flow.

Abstract: The invention provides a compound of Formula (I) or a pharmaceutically acceptable salt of the compound, wherein R1, R2, R3 and R4 are as described herein; pharmaceutical compositions thereof; and the use thereof in treating diseases, conditions or disorders modulated by the inhibition of an acetyl-CoA carboxylase enzyme(s) in an animal.

Abstract: Compounds of Formula I that inhibit the activity of the diacylglycerol acyltransferase 2 (DGAT2) and their uses in the treatment of diseases linked thereto in animals are described herein.

Abstract: Systems and methods for displaying electronic messages are disclosed. In some embodiments, a method includes, at a computing device, displaying an electronic message user interface and receiving a search query while displaying the electronic message user interface. The search query corresponds to a category identifier, of a plurality of predefined category identifiers. The method also includes, in response to receiving the search query, displaying one or more electronic messages, in a plurality of electronic messages, that satisfy the search query and concurrently displaying a set of data associated with an object identifier in a respective electronic message of the one or more electronic messages. The object identifier corresponds to the category identifier, and the set of data includes one or more entries defined in a data configuration associated with the category identifier.

Abstract: Packaging including a coiled and optionally prelubricated catheter, its distal end insertable into the urethra, a slidable hygienic sheath, a proximal catheter end for voiding urine from the distal end through the assembly to the proximal end. Mutually rotatable elements providing for withdrawal of the catheter from its coiled state to an extended state, and retraction of the catheter back to its coiled state. Methods of extending the catheter, inserting it into the urethra, and voiding urine through the catheter, without requiring complete removal from the catheter packaging. A kit including automatic extrusion of the catheter's distal end upon package opening, and a water pouch for hydrophilic lubrication, and sanitary wipes for reducing the likelihood of infection. A catheter within a flexible and optionally coiled tube, a slidable hygienic sheath covering a catheter's distal end that can move along the length of the catheter during insertion.

Abstract: A process is provided for preparing a defined starting operation of a motor vehicle selectable by the driver, having a starting element arranged between an engine and a transmission. In the event of a maximal power demand by the driver and in the event of the selection of the defined starting operation by an electronic control unit, the rotational speed or the torque of the engine is set to a specified value, wherein the specified value is automatically determined by the electronic control unit as function of a determined friction parameter, by which at least one relative prediction concerning the transmissible drive torque to he expected for the acceleration operation can be made, such that, by use of the specified during the starting and acceleration operation following the preparation, the maximally possible drive torque is achieved for the best possible acceleration.

Abstract: A digital media advertisement delivery system comprising a real time bidding (RTB) platform and a plurality of bidder computers. The RTB platform is configured to receive an indication of an opportunity to display a digital media advertisement to a consumer, and generating a bid request for auctioning the opportunity to a plurality of bidders, the bid request comprising a plurality of fields including information about the opportunity. The plurality of bidder computers are configured to receive the bid request comprising a first plurality of fields including information about the opportunity, decide, based on the received information in the plurality of fields, whether or not to bid, and send a bid response, when decision is to bid, comprising a second plurality of response fields, at least some of which include information in direct response to the first plurality of fields.

Abstract: The invention provides a compound of Formula (I) or a pharmaceutically acceptable salt of the compound, wherein R1, R2, R3 and R4 are as described herein; pharmaceutical compositions thereof; and the use thereof in treating diseases, conditions or disorders modulated by the inhibition of an acetyl-CoA carboxylase enzyme(s) in an animal.

Abstract: Myeloperoxidase inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, cardiovascular conditions.

Abstract: A distributed computing system is configured to compute operational data for a video advertisement delivery system. Cloud-based resource are used to calculate operational parameters such as geographical data, unique advertisement delivery instances and segments of consumers that received the video advertisements.

Abstract: Techniques and systems for operating a video ad exchange includes controlling an ad server to receive ad requests from viewer devices, provide ad responses to viewer devices, generate an ad delivery data file that includes information about delivery of ads to the viewer devices, and transfer the ad delivery data file to a distributed computing cloud. The technique further includes controlling an ad data infrastructure mechanism to download the cloud-based ad delivery data file into a local memory, and process the copied ad delivery data file to generate billing data. An ad data infrastructure mechanism receives a configuration file from the ad server, verifies that all items in the configuration file from the ad server were used in the generation of the first billing data, and removes non-verifiable items from the first billing data to generate a final billing data.