Abstract: The disclosure features fusion proteins that are conditionally active variants of a cytokine of interest. In one aspect, the full-length polypeptides of the invention have reduced or minimal cytokine-receptor activating activity even though they contain a functional cytokine polypeptide. Upon activation, e.g., by cleavage of a linker that joins a blocking moiety, e.g. a steric blocking polypeptide, in sequence to the active cytokine, the cytokine can bind its receptor and effect signaling. Typically, the fusion proteins further comprise an in vivo half-life extension element, which may be cleaved from the cytokine in the tumor microenvironment.

Abstract: The disclosure features fusion proteins that are conditionally active variants of IL-2. In one aspect, the full-length polypeptides of the invention have reduced or minimal cytokine-receptor activating activity even though they contain a functional cytokine polypeptide. Upon activation, e.g., by cleavage of a linker that joins a blocking moiety, e.g., a steric blocking polypeptide, in sequence to the active cytokine, the cytokine can bind its receptor and effect signaling.

Abstract: There is provided a packet-based communication system for conducting voice or video calls over a packet-based network. A client application on a first terminal is configured to determine an availability of one or more other, second user terminals installed with other instances of the client application, and to present a near-end user with an option to select one of said second user terminals for use by the near-end user in conjunction with the first user terminal when conducting a voice or video call with a far-end user via the client instances and packet-based communication system; thereby enabling the voice or video call to be conducted using the second terminal to consume or generate at least one stream of the call whilst the first user terminal concurrently generates or consumes at least another stream of the call or controls the call.

Abstract: A notification of a received communication relating to a communication chain is presented. An input is received in response to that notification. Until a predetermined event occurs, the presentation of at least one type of notification of further received communications relating to that communication chain is suspended in dependence on said input.

Abstract: There is provided a packet-based communication system for conducting voice or video calls over a packet-based network. A client application on a first terminal is configured to determine an availability of one or more other, second user terminals installed with other instances of the client application, and to present a near-end user with an option to select one of said second user terminals for use by the near-end user in conjunction with the first user terminal when conducting a voice or video call with a far-end user via the client instances and packet-based communication system; thereby enabling the voice or video call to be conducted using the second terminal to consume or generate at least one stream of the call whilst the first user terminal concurrently generates or consumes at least another stream of the call or controls the call.

Abstract: A user terminal comprising: a display having an available display area; a processor configured to run a client application having a user interface capable of operating in a full screen mode whereby a single layer of content is displayed in the available display area or in a split-view mode; wherein the client application is configured to: detect, while controlling the user interface to operate in the full screen mode, a user selection that the user interface operates in the split-view mode, and in response display a first layer of content in a predetermined position to partially overlap a second layer of content such that a portion of the second layer of content is displayed in the available display area and a remaining portion of the second layer of content is not displayed; and display an indicator providing an indication of how content displayed on the two layers is related.

Abstract: A notification of a received communication relating to a communication chain is presented. An input is received in response to that notification. Until a predetermined event occurs, the presentation of at least one type of notification of further received communications relating to that communication chain is suspended in dependence on said input.

Abstract: A notification of a received communication relating to a communication chain is presented. An input is received in response to that notification. Until a predetermined event occurs, the presentation of at least one type of notification of further received communications relating to that communication chain is suspended in dependence on said input.

Abstract: A user terminal comprising: a display having an available display area; a processor configured to run a client application having a user interface capable of operating in a full screen mode whereby a single layer of content is displayed in the available display area or in a split-view mode; wherein the client application is configured to: detect, whilst controlling the user interface to operate in the full screen mode, a user selection that the user interface operates in the split-view mode, and in response display a first layer of content in a predetermined position to partially overlap a second layer of content such that a portion of the second layer of content is displayed in the available display area and a remaining portion of the second layer of content is not displayed; and display an indicator providing an indication of how content displayed on the two layers is related.

Abstract: A notification of a received communication relating to a communication chain is presented. An input is received in response to that notification. Until a predetermined event occurs, the presentation of at least one type of notification of further received communications relating to that communication chain is suspended in dependence on said input.

Abstract: There is provided a packet-based communication system for conducting voice or video calls over a packet-based network. A client application on a first terminal is configured to determine an availability of one or more other, second user terminals installed with other instances of the client application, and to present a near-end user with an option to select one of said second user terminals for use by the near-end user in conjunction with the first user terminal when conducting a voice or video call with a far-end user via the client instances and packet-based communication system; thereby enabling the voice or video call to be conducted using the second terminal to consume or generate at least one stream of the call whilst the first user terminal concurrently generates or consumes at least another stream of the call or controls the call.