Abstract: The application relates to a deep scanning mutagenesis library to interrogate phenotypic changes in a population of cells comprising a plurality of CRISPR-Cas system guide RNAs targeting genomic sequences within at least one continuous genomic region, wherein the guide RNAs target at least 100 genomic sequences upstream of a PAM sequence for every 1000 base pairs within the continuous genomic region and methods for their use.

Abstract: Devices, methods and graphical user interfaces for manipulating user interfaces based on fingerprint sensor inputs are provided. While a display of an electronic device with a fingerprint sensor displays a first user interface, the device may detect movement of a fingerprint on the fingerprint sensor. In accordance with a determination that the movement of the fingerprint is in a first direction, the device allows navigating through the first user interface, and in accordance with a determination that the movement of the fingerprint is in a second direction different from the first direction, the device allows displaying a second user interface different from the first user interface on the display.

Abstract: A method is provided for determining a location to place a mass on a wheel assembly. A first set of acceleration data is collected from a plurality of inertial measurement units (IMU's) that are mounted to a removably attachable object that is attached to a wheel of the vehicle in a manner that inhibits the object from coming off of the vehicle when the vehicle is in motion. The first set of acceleration data is collected while operating the vehicle at a first speed. The first set of acceleration data is used to determine an offset between a center of the object and a bearing center of the wheel assembly. A second set of acceleration data is collected from the plurality of inertial measurement units (IMU's). The second set of acceleration data is collected while operating the vehicle at second speed that is greater than the first speed.

Abstract: This application relates to processes and intermediates for the preparation of the PD-1/PD-L1 inhibitor (R)-1-((7-cyano-2-(3?-((2-(difluoromethyl)-7-((3-hydroxypyrrolidin-1-yl)methyl)pyrido[3,2-d]pyrimidin-4-yl)amino)-2,2?-dimethyl-[1,1?-biphenyl]-3-yl)benzo[d]oxazol-5-yl)methyl)piperidine-4-carboxylic acid, and salts and crystalline forms thereof, where the PD-1/PD-L1 inhibitor and solid forms and salt forms thereof are useful in the treatment of various diseases including infectious diseases and cancer.

Abstract: An out-of-oven system for free-form fabrication of continuous carbon fiber composites includes a dielectric barrier discharge (DBD) applicator configured to create an electric field proximal to the continuous carbon fiber composite. The DBD applicator includes a first electrode disposed within a dielectric barrier, and a second electrode spaced apart from the first electrode. The first and second electrodes are configured to allow the continuous carbon fiber composite to pass therebetween to cure the continuous carbon fiber composite. The system uses Joule heating to cure the continuous carbon fiber composite.

Abstract: A solar cell includes a semiconductor material having a dielectric layer over a light-receiving surface of the semiconductor material, a plurality of printed fire-through contacts passing substantially through the dielectric layer, each contact extending longitudinally in a first dimension, and a conductive finger extending longitudinally in a second dimension substantially perpendicular to the first dimension and electrically connecting the plurality of contacts to first and second busbars at opposite ends of the conductive finger. The conductive finger has at least one first portion overlaying and electrically connecting to the plurality of contacts, wherein each of the plurality of contacts extends beyond the first portion of the conductive finger at one or both sides of the first portion of the conductive finger in the first dimension, and wherein the first portion of the conductive finger overlays the dielectric.

Abstract: At least one proof transaction for recording on a blockchain comprises at least an s-part for an Elliptic Curve Digital Signature Algorithm, ECDSA, signature. The s-part is computed from a set of signature components, each provided by a participant of a signing subset of a set of keyshare participants. Each of keyshare participant holds an ephemeral keyshare of an unknown ephemeral key, and each of the signing components is provided by the participant of the signing subset based on their ephemeral keyshare. The at least one proof transaction indicates an r-challenge of at least one challenge transaction, and a node of a blockchain network applies signature verification to: (i) the s-part of the at least one proof transaction, and (ii) one of: (iia) an r-part of the r-challenge, (iib) an r-part of the at least one proof transaction, and in that event checks that that r-part satisfies the r-challenge.

Abstract: Non-combustible aerosol provision device 100 for generating an aerosol from an aerosol-generating material comprised in a consumable for being received by the device. The device comprises a chamber 102 for receiving the consumable, wherein the device is configured to generate the aerosol from the aerosol-generating material when the consumable is received in the chamber 102. The device 100 further comprises a consumable holder 500 for holding the consumable in the chamber 102, wherein the consumable holder 500 comprises at least two selectively engageable gripping members which are spaced from one another in an axial direction of the chamber 102 to grip different respective points on the consumable, such that the consumable holder is capable of holding, by use of the selectively engageable gripping members, one at a time, each of a plurality of differently-dimensioned consumables at a desired position in the chamber 102.

Abstract: A non-combustible aerosol provision device for generating an aerosol from an aerosol-generating material is disclosed. The non-combustible aerosol provision device includes a chamber for receiving a consumable including aerosol-generating material to enable the non-combustible aerosol provision device to generate an aerosol from the aerosol-generating material, wherein the chamber is configured to accommodate, one at a time, a first consumable comprising aerosol-generating material at a first axial position in the chamber and a second consumable including aerosol-generating material having different dimensions to those of the first consumable at a second axial position in the chamber.

Abstract: The application relates to a deep scanning mutagenesis library to interrogate phenotypic changes in a population of cells comprising a plurality of CRISPR-Cas system guide RNAs targeting genomic sequences within at least one continuous genomic region, wherein the guide RNAs target at least 100 genomic sequences upstream of a PAM sequence for every 1000 base pairs within the continuous genomic region and methods for their use.

Abstract: A telepresence robot may include a drive system, a control system, an imaging system, and a mapping module. The mapping module may access a plan view map of an area and tags associated with the area. In various embodiments, each tag may include tag coordinates and tag information, which may include a tag annotation. A tag identification system may identify tags within a predetermined range of the current position and the control system may execute an action based on an identified tag whose tag information comprises a telepresence robot action modifier. The telepresence robot may rotate an upper portion independent from a lower portion. A remote terminal may allow an operator to control the telepresence robot using any combination of control methods, including by selecting a destination in a live video feed, by selecting a destination on a plan view map, or by using a joystick or other peripheral device.

Abstract: A non-combustible aerosol provision device for generating an aerosol from an aerosol-generating material is provided. The device includes a chamber for receiving a consumable including aerosol-generating material to enable the non-combustible aerosol provision device to generate an aerosol from the aerosol-generating material. The device further includes an adjustment mechanism to allow a user to adjust a dimension of the chamber to allow the chamber to accommodate, one at a time, each of a plurality of consumables having different sizes.

Abstract: A non-combustible aerosol provision device for generating an aerosol from aerosol-generating material in a consumable is disclosed. The non-combustible aerosol provision device includes a retention apparatus configured to hold in position, one at a time, each of the plurality of consumables comprising aerosol-generating material of different sizes.

Abstract: An envelope sealing and flipping system can be incorporated into a mail inserter system to seal an envelope with a complete unbroken glue line and simultaneously flip the envelope face-up for downstream processing. The system includes a flip cage that receives an envelope and a moveable wetting brush that contacts the flap. The flip cage rotates, causing the flap to drag underneath the wetting brush, and realigning the envelope with a sealer nip which seals the envelope. The flip cage rotates continuously to receive, flip, and seal many envelopes.

Abstract: An imprinting apparatus includes a silicon master and an anti-stick layer coating the silicon master. The silicon master includes a plurality of features positioned at an average pitch of less than about 425 nm, each of the plurality of features comprises a depression having an opening with its largest opening dimension being less than about 300 nm. The anti-stick layer includes a crosslinked silane polymer network.

Abstract: A building comprises a network of energy storage and energy consuming assets, which is connected to an alternating current electric supply grid having a normal frequency through an energy management system linked to a server. The energy management system measures over a period of time the energy consumption against time of the energy consuming assets and stores the measurements taken and measures over a period of time the energy stored against time in the energy storing assets and stores the measurements taken. The measurements of energy consumption and energy stored are used to derive the base net energy need in particular time periods. The net energy need in individual time periods is exported to one or more third parties.

Abstract: A system and a method for configuring one or more fire extinguishers within a compartment include a configuration control unit configured to determine one or more fluid flow paths within the compartment from a fluid dynamics model. The configuration control unit is further configured to determine a configuration for one or more nozzles of the one or more fire extinguishers based on the one or more fluid paths.

Abstract: A massage device has a position adjustable handle along a handle slot that extends along a portion of the cane support. The cane support has a support extension portion, or the long substantially linear portion, an arc portion that extends from the support extension in an arc or cure and a head portion. The handle slot may extend a portion of the length of the cane support and along the support extension to the head portion. A vibration device is coupled to the head end of the cane support and may be decoupled from the cane support by a vibration dampening material that extends around the vibration device within a chamber. The vibration dampening material extend out to form a locking ring between the vibration assembly and the massage head. A user can comfortably hold the massage head against their body without excessive vibration in the cane support or handle.

Abstract: The present invention primarily relates to certain herbicidal compositions based on the herbicidal active ingredients (A) fluazifop or an ester thereof, (B) triclopyr or an ester or salt thereof and (C) a diquat dihalide salt, optionally additionally comprising (D) imazapic or a salt thereof. The invention also relates to the field of plant protection and environmental health, and to methods and uses of the herbicidal compositions of the present invention for controlling unwanted plant growth.

Abstract: Information associated with a controlled-environment facility resident communications and/or data device, such as device location within the controlled-environment facility, may be used to determine whether the resident device is approved for two-way video visitation or restricted to on-way video visitation. Video visitation may be initiated and voice and video captured and streamed by a non-resident communications and/or data device, as well as voice and/or video captured and streamed by the resident device, is received by a controlled-environment facility electronic communications management system. Voice and video captured at the non-resident device is transmitted to the resident device and, if the resident device is permitted two-way video visitation, voice and video captured by the resident device is transmitted to the non-resident device, if the resident device is restricted to one-way video visitation, only voice is transmitted to the non-resident device.