Abstract: An apparatus including: a housing configured for installation in a landfill; a differential pressure sensor and at least one gas sensor in the housing; and a first valve configured to control landfill gas (LFG) flow to the at least one gas sensor, wherein the first valve is configured to open when the differential pressure sensor detects a selected pressure difference or pressure difference change between the atmospheric air pressure and the LFG pressure.

Abstract: The present application is directed to, in part, nucleotide analogs with a novel design of a 3?-OH reversible terminator that comprises an enzyme-cleavable linkage.

Abstract: An analytics system uses soil health indicators to determine metrics for soil samples. In an embodiment, the analytics system receives metadata describing a soil sample, where the metadata indicates one or more types of crops grown in a geographical location having the soil sample. The analytics system determines nucleic acid sequence reads of the soil sample. The analytics system determines taxonomic information of the nucleic acid sequence reads. The analytics system determines microbial composition of the soil sample using the taxonomic information. The analytics system determines reference metrics of soil samples from geographical locations in which the one or more types of crop were grown. The analytics system determines a metric of the soil sample using the microbial composition and the reference metrics. The analytics system transmits the metric to a client device.

Abstract: The invention provides flow batteries and methods of using flow batteries that reduce loss of capacity. The loss of capacity may be mitigated by electrically oxidizing an organic species in the negolyte.

Abstract: Disclosed herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, that are inhibitors of Polo Like Kinase 4 (PLK4). Also disclosed herein are pharmaceutical compositions comprising the compounds of Formula (I), or pharmaceutically acceptable salts thereof, and one or more pharmaceutically acceptable excipients. Further disclosed herein are methods of treating cancer in a subject in need thereof, comprising administering to the subject an amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: The present invention relates to compounds useful for degrading BTK via a ubiquitin proteolytic pathway. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Abstract: An electro-hydraulic brake assembly comprises a hydraulic control unit (HCU) body having a top surface and a bottom surface opposite the top surface and defining a master cylinder bore and a pressure supply bore. A fluid reservoir is disposed on the top surface. A primary piston is slidably disposed in the master cylinder bore and configured to supply brake fluid to a wheel brake in response to pressing of a brake pedal. A pressure supply unit includes: a pressure supply piston disposed within the pressure supply bore; a motor located on the bottom surface of the HCU body and having a motor shaft. An actuator mechanism includes a threaded shaft configured to be rotated by the motor shaft, and a nut coupled to the pressure supply piston, together causing the pressure supply piston to translate linearly through the pressure supply bore in response to rotation of the motor shaft.

Abstract: The present application describes various methods and devices for providing content to users. In one aspect, a method includes, for each content item of a set of content items, obtaining a score for the content item using a recommender system, the score corresponding to a calculation of subsequent repeated engagement by a user with the content item. The method also includes ranking the set of content items based on the respective scores and providing recommendation information to the user for one or more highest ranked content items in the set of content items.

Abstract: A method of thermal cycling a droplet, including providing a droplet actuator with heaters establishing a first thermal zone and second thermal zone in a substantially oil-filled droplet operations gap; a thermal cycling path comprising droplet operations electrodes comprising a first droplet operations electrode in the first thermal zone and a second droplet operations electrode in the second thermal zone, wherein the first and second droplet operations electrodes are within 5 mm of each other; a first temperature at the first droplet operations electrode and a second temperature at the second droplet operations electrode, wherein the first and second temperatures differ by at least about 10° C.; and using the droplet operations electrodes, transporting the droplet in a cycling pattern for multiple cycles along the thermal cycling path between the first droplet operations electrode and the second droplet operations electrode. Cartridges and systems are also provided.

Abstract: Techniques for managing network-accessible infrastructure metadata are provided. A method includes receiving a resource request comprising resource metadata corresponding to a network-accessible infrastructure resource, determining whether to commit the resource request based at least in part on a constraint associated with the network-accessible infrastructure resource, and, in accordance with a determination to commit the resource request: generating, by the computer system, a resource identifier describing resource metadata in accordance with the resource request, storing, by the computer system, the resource metadata in a data store in communication with the computer system, receiving, by the computer system, a data request to provide the resource metadata described by the resource identifier, and providing, by the computer system, the resource metadata described by the resource identifier in accordance with the data request.

Abstract: Methods for calibrating a multispectral analysis system include calibrating the system to detect fluorescence emission from a first fluorescent entity in a biological sample that includes the first fluorescent entity and a second fluorescent entity using a calibration sample, where the calibration sample features a first concentration of the first fluorescent entity and a second concentration of the second fluorescent entity, and where the first concentration is larger than the second concentration.

Abstract: A robotic cleaner includes a housing, a suction conduit with an opening, and a leading roller mounted in front of a brush roll. An inter-roller air passageway may be defined between the leading roller and the brush roll wherein the lower portion of the leading roller is exposed to a flow path to the suction conduit and an upper portion of the leading roller is outside of the flow path. Optionally, a combing unit includes a plurality of combing protrusions extending into the leading roller and having leading edges not aligned with a center of the leading roller. Optionally, a sealing strip is located along a rear side of the opening and along a portion of left and right sides of the opening. The underside may define side edge vacuum passageways extending from the sides of the housing partially between the leading roller and the sealing strip towards the opening.

Abstract: Examples described herein relate to offload reliable transport management to a network interface device and store packets to be resent, based on received packet receipt acknowledgements (ACKs), into one or more kernel space queues that are also accessible in user space.

Abstract: A computer-implemented system and method for planning recurring events is provided. Event objects for events are stored in a database. A trigger notifying the beginning of an event is received and an event object representing the event is generated in response to the trigger. An event class is associated with a set of parameters and is assigned to the event object. A set of activity data is created for the event object and each activity data includes structured and unstructured data describing an event activity occurred during the event. At least one event object is retrieved from the database as a model and the parameter values of the model event object are displayed. At least one of the parameter values of the model event object is modified and the modification is reflected against other parameter values of the model event object that are dependent on the modified parameter value.

Abstract: Aspects of a charging system may involve altering the duty cycle of the shaped charge signal over a period of time to alter an average current supplied to an electrochemical device while maintain the maximum current of the charge signal. For example, the average current of the charge signal used to charge a battery may be adjusted by varying the duty cycle or peak current of the shaped charge signal, and may be based, in some instances, on the state of charge, temperature, and/or impedance of the battery. In some instances, control over the average or total current of the charge signal is constrained by the maximum current that the system can supply, such that altering the duty cycle of the charge signal provides control over an average current of the charge signal without needing to supply additional current sources.

Abstract: The invention provides anti-Jagged2 antibodies and methods of using the same.

Abstract: Disclosed are techniques for employing deep learning to analyze radar signals. In an aspect, an on-board computer of a host vehicle receives, from a radar sensor of the vehicle, a plurality of radar frames, executes a neural network on a subset of the plurality of radar frames, and detects one or more objects in the subset of the plurality of radar frames based on execution of the neural network on the subset of the plurality of radar frames. Further, techniques for transforming polar coordinates to Cartesian coordinates in a neural network are disclosed. In an aspect, a neural network receives a plurality of radar frames in polar coordinate space, a polar-to-Cartesian transformation layer of the neural network transforms the plurality of radar frames to Cartesian coordinate space, and the neural network outputs the plurality of radar frames in the Cartesian coordinate space.

Abstract: The present invention provides anti-HtrA1 antibodies (including bispecific anti-HtrA1 anti-Factor D antibodies) and methods of making and using the same, for example, in methods of treating HtrA1-associated disorders, ocular disorders, and/or complement-associated disorders.

Abstract: The present invention provides, among other aspects, functionalized chromophoric polymer dots comprising a hydrophobic core and a hydrophilic cap, and bioconjugates thereof. Also provided are improved methods for preparing functionalized chromophoric polymer dots. Methods for in vivo imaging and molecular labeling are also disclosed.

Abstract: Provided herein are methods and systems for analyzing a sample of a subject to determine whether the subject has, or is at risk of having or developing, a cancer, such as lung cancer.