Patents by Inventor Daniel Zabetakis

Daniel Zabetakis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10928351
    Abstract: An electrochemical cell includes a working electrode in contact with an aqueous electrolyte solution, a counter electrode in contact with the aqueous electrolyte solution, and a reference electrode in contact with the aqueous electrolyte solution. The working electrode comprises a plasma modified epitaxial synthesized graphene surface fabricated on SiC.
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: February 23, 2021
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Scott A. Trammell, Rachael L. Myers-Ward, Sandra C. Hangarter, Daniel Zabetakis, David A. Stenger, David Kurt Gaskill, Scott G. Walton
  • Publication number: 20200315025
    Abstract: Patterns of homogenous, electroless-plated metals within and on one or both sides of a porous substrate (such as nanocellulose sheets) enable the formation of an matrix of metal within pores of the substrate that can connect patterns on both sides of the substrate. These can serve as circuits with applications in, for example, wearable electronics.
    Type: Application
    Filed: March 24, 2020
    Publication date: October 1, 2020
    Inventors: Jonathan D. Yuen, David A. Stenger, Daniel Zabetakis, Scott Walper, Banahalli R. Ratna
  • Patent number: 10611809
    Abstract: A single-domain antibody (sdAb) is produced by causing a bacteria to express the sdAb into cytoplasm of the bacteria, wherein the sdAb is expressed as a fusion protein with the acid tail of ?-synuclein. In embodiments, the protein is free of a periplasmic location tag. Such antibodies have the unexpected ability to refold after thermal denaturation.
    Type: Grant
    Filed: March 27, 2019
    Date of Patent: April 7, 2020
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Daniel Zabetakis, George P. Anderson, Ellen R. Goldman, Kendrick Turner, P. Audrey Brozozog Lee
  • Patent number: 10577401
    Abstract: A nucleic acid encodes a single-domain antibody (sdAb) is produced by causing a bacteria to express the sdAb into cytoplasm of the bacteria, wherein the sdAb is expressed as a fusion protein with the acid tail of ?-synuclein. In embodiments, the protein is free of a periplasmic location tag. Such antibodies have the unexpected ability to refold after thermal denaturation.
    Type: Grant
    Filed: March 27, 2019
    Date of Patent: March 3, 2020
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Daniel Zabetakis, George P. Anderson, Ellen R. Goldman, Kendrick Turner, P. Audrey Brozozog Lee
  • Publication number: 20190211068
    Abstract: A single-domain antibody (sdAb) is produced by causing a bacteria to express the sdAb into cytoplasm of the bacteria, wherein the sdAb is expressed as a fusion protein with the acid tail of ?-synuclein. In embodiments, the protein is free of a periplasmic location tag. Such antibodies have the unexpected ability to refold after thermal denaturation.
    Type: Application
    Filed: March 27, 2019
    Publication date: July 11, 2019
    Inventors: Daniel Zabetakis, George P. Anderson, Ellen R. Goldman, Kendrick Turner, P. Audrey Brozozog Lee
  • Publication number: 20190211069
    Abstract: A nucleic acid encodes a single-domain antibody (sdAb) is produced by causing a bacteria to express the sdAb into cytoplasm of the bacteria, wherein the sdAb is expressed as a fusion protein with the acid tail of ?-synuclein. In embodiments, the protein is free of a periplasmic location tag. Such antibodies have the unexpected ability to refold after thermal denaturation.
    Type: Application
    Filed: March 27, 2019
    Publication date: July 11, 2019
    Inventors: Daniel Zabetakis, George P. Anderson, Ellen R. Goldman, Kendrick Turner, P. Audrey Brozozog Lee
  • Patent number: 10294283
    Abstract: Methods of producing a single-domain antibody (sdAb) include causing a bacteria to express the sdAb into cytoplasm of the bacteria, wherein the sdAb is expressed as a fusion protein with the acid tail of ?-synuclein; and then purifying the sdAb, wherein the fusion protein is expressed free of a periplasmic location tag. Such antibodies have the unexpected ability to refold after thermal denaturation.
    Type: Grant
    Filed: January 17, 2014
    Date of Patent: May 21, 2019
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Daniel Zabetakis, George P. Anderson, Ellen R. Goldman, Kendrick Turner, P. Audrey Brozozog Lee
  • Patent number: 10247716
    Abstract: Described herein are new recognition elements (antibodies or functional fragments thereof) that effectively bind to trinitrotoluene (TNT). Also disclosed is a single chain fragment recognition element.
    Type: Grant
    Filed: January 6, 2016
    Date of Patent: April 2, 2019
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Jinny Lin Liu, Daniel Zabetakis, Ellen R. Goldman, George P. Anderson
  • Patent number: 10246514
    Abstract: Described herein is the development of recombinant single domain antibodies, also known as nanobodies, that may provide better therapeutic results or be useful for diagnostic applications of B-cell lymphomas, or in other applications where an antibody to CD20 may be useful.
    Type: Grant
    Filed: September 12, 2017
    Date of Patent: April 2, 2019
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Jinny Lin Liu, Daniel Zabetakis, Ellen R. Goldman, George P. Anderson
  • Publication number: 20190033247
    Abstract: An electrochemical cell includes a working electrode in contact with an aqueous electrolyte solution, a counter electrode in contact with the aqueous electrolyte solution, and a reference electrode in contact with the aqueous electrolyte solution. The working electrode comprises a plasma modified epitaxial synthesized graphene surface fabricated on SiC.
    Type: Application
    Filed: July 30, 2018
    Publication date: January 31, 2019
    Inventors: Scott A. Trammell, Rachael L. Myers-Ward, Sandra C. Hangarter, Daniel Zabetakis, David A. Stenger, David Kurt Gaskill, Scott G. Walton
  • Publication number: 20180079822
    Abstract: Described herein is the development of recombinant single domain antibodies, also known as nanobodies, that may provide better therapeutic results or be useful for diagnostic applications of B-cell lymphomas, or in other applications where an antibody to CD20 may be useful.
    Type: Application
    Filed: September 12, 2017
    Publication date: March 22, 2018
    Inventors: Jinny Lin Liu, Daniel Zabetakis, Ellen R. Goldman, George P. Anderson
  • Patent number: 9857294
    Abstract: Described herein is an approach using inexpensive, disposable chemical sensor probes that can be mounted on a small unmanned aerial vehicles (UAVs) and used to analyze a site (such as one known or suspected to contain explosive residue, spilled material or contaminated soil) without the need for a person to conduct ground operations at the site. The method involves contacting a soil or a surface with a filter paper wetted with a solvent, then subjecting the filter paper to spectroscopy, thus detecting a possible variation indicative of one or more analytes, wherein the solvent is a deep eutectic solvents consisting of a mixture of ethylene glycol and choline chloride.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: January 2, 2018
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Daniel Zabetakis, Scott A. Trammell, Walter J. Dressick, David A. Stenger, Jasenka Verbarg
  • Patent number: 9857293
    Abstract: Described herein is an approach using inexpensive, disposable chemical sensor probes that can be mounted on a small unmanned aerial vehicles (UAVs) and used to analyze a site (such as one known or suspected to contain explosive residue, spilled material or contaminated soil) without the need for a person to conduct ground operations at the site. The method involves contacting a soil or a surface with a filter paper wetted with a solvent, then subjecting the filter paper to voltammetry and/or spectroscopy, thus detecting a possible variation indicative of one or more analytes, wherein the solvent is the deep eutectic solvent consisting of a mixture of ethylene glycol and choline chloride.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: January 2, 2018
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Daniel Zabetakis, Scott A. Trammell, Walter J. Dressick, David A. Stenger, Jasenka Verbarg
  • Publication number: 20170074825
    Abstract: Described herein is an approach using inexpensive, disposable chemical sensor probes that can be mounted on a small unmanned aerial vehicles (UAVs) and used to analyze a site (such as one known or suspected to contain explosive residue, spilled material or contaminated soil) without the need for a person to conduct ground operations at the site. The method involves contacting a soil or a surface with a filter paper wetted with a solvent, then subjecting the filter paper to voltammetry and/or spectroscopy, thus detecting a possible variation indicative of one or more analytes, wherein the solvent is the deep eutectic solvent consisting of a mixture of ethylene glycol and choline chloride.
    Type: Application
    Filed: November 18, 2016
    Publication date: March 16, 2017
    Inventors: Daniel Zabetakis, Scott A. Trammell, Walter J. Dressick, David A. Stenger, Jasenka Verbarg
  • Publication number: 20170074785
    Abstract: Described herein is an approach using inexpensive, disposable chemical sensor probes that can be mounted on a small unmanned aerial vehicles (UAVs) and used to analyze a site (such as one known or suspected to contain explosive residue, spilled material or contaminated soil) without the need for a person to conduct ground operations at the site. The method involves contacting a soil or a surface with a filter paper wetted with a solvent, then subjecting the filter paper to spectroscopy, thus detecting a possible variation indicative of one or more analytes, wherein the solvent is a deep eutectic solvents consisting of a mixture of ethylene glycol and choline chloride.
    Type: Application
    Filed: November 18, 2016
    Publication date: March 16, 2017
    Inventors: Daniel Zabetakis, Scott A. Trammell, Walter J. Dressick, David A. Stenger, Jasenka Verbarg
  • Patent number: 9557296
    Abstract: Described herein is an approach using inexpensive, disposable chemical sensor probes that can be mounted on a small unmanned aerial vehicles (UAVs) and used to analyze a site (such as one known or suspected to contain explosive residue, spilled material or contaminated soil) without the need for a person to conduct ground operations at the site. The method involves contacting a soil or a surface with a filter paper wetted with a solvent, then subjecting the filter paper to voltammetry and/or spectroscopy, thus detecting a possible variation indicative of one or more analytes, wherein the solvent is selected from the group consisting of polar aprotic or protic solvents having a boiling point of at least 100° C., room temperature ionic liquids, and deep eutectic solvents.
    Type: Grant
    Filed: August 27, 2014
    Date of Patent: January 31, 2017
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Daniel Zabetakis, Scott A. Trammell, Walter J. Dressick, David A. Stenger, Jasenka Verbarg
  • Publication number: 20160200834
    Abstract: Described herein are new recognition elements (antibodies or functional fragments thereof) that effectively bind to trinitrotoluene (TNT). Also disclosed is a single chain fragment recognition element.
    Type: Application
    Filed: January 6, 2016
    Publication date: July 14, 2016
    Inventors: Jinny Lin Liu, Daniel Zabetakis, Ellen R. Goldman, George P. Anderson
  • Publication number: 20160061775
    Abstract: Described herein is an approach using inexpensive, disposable chemical sensor probes that can be mounted on a small unmanned aerial vehicles (UAVs) and used to analyze a site (such as one known or suspected to contain explosive residue, spilled material or contaminated soil) without the need for a person to conduct ground operations at the site. The method involves contacting a soil or a surface with a filter paper wetted with a solvent, then subjecting the filter paper to voltammetry and/or spectroscopy, thus detecting a possible variation indicative of one or more analytes, wherein the solvent is selected from the group consisting of polar aprotic or protic solvents having a boiling point of at least 100° C., room temperature ionic liquids, and deep eutectic solvents.
    Type: Application
    Filed: August 27, 2014
    Publication date: March 3, 2016
    Applicant: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Daniel Zabetakis, Scott A. Trammell, Walter J. Dressick, David A. Stenger, Jasenka Verbarg
  • Patent number: 9267930
    Abstract: Described herein are new recognition elements (antibodies or functional fragments thereof) that effectively bind to trinitrotoluene (TNT). Also disclosed is a single chain fragment recognition element.
    Type: Grant
    Filed: October 17, 2012
    Date of Patent: February 23, 2016
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Jinny Lin Liu, Daniel Zabetakis, Ellen R. Goldman, George P. Anderson
  • Publication number: 20150268214
    Abstract: Described herein are new recognition elements (antibodies or functional fragments thereof) that effectively bind to trinitrotoluene (TNT). Also disclosed is a single chain fragment recognition element.
    Type: Application
    Filed: October 17, 2012
    Publication date: September 24, 2015
    Inventors: Jinny Lin Liu, Daniel Zabetakis, Ellen R. Goldman, George P. Anderson