Patents by Inventor Danith Ly

Danith Ly has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stabilized STAT3 decoy oligonucleotides and uses therefor
    Patent number: 10183977
    Abstract: The present invention is based, at least in part, on novel, unimolecular STAT3 oligonucleotide decoys exhibiting increased in vivo stability as compared to previously known decoys which are effective in inhibiting STAT3 when administered systemically. The invention is also based on pharmaceutical compositions comprising these unimolecular decoys, and methods for using these decoys in the treatment of cancer.
    Type: Grant
    Filed: June 1, 2017
    Date of Patent: January 22, 2019
    Assignees: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, CARNEGIE MELLON UNIVERSITY
    Inventors: Jennifer R. Grandis, Daniel E. Johnson, Danith Ly
  • Stabilized STAT3 Decoy Oligonucleotides and Uses Therefor
    Publication number: 20180134758
    Abstract: The present invention is based, at least in part, on novel, unimolecular STAT3 oligonucleotide decoys exhibiting increased in vivo stability as compared to previously known decoys which are effective in inhibiting STAT3 when administered systemically.
    Type: Application
    Filed: June 1, 2017
    Publication date: May 17, 2018
    Applicants: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, CARNEGIE MELLON UNIVERSITY
    Inventors: JENNIFER R. GRANDIS, DANIEL E. JOHNSON, DANITH LY
  • Gamma-PNA miniprobes for fluorescent labeling
    Patent number: 9926592
    Abstract: A category of ?PNA miniprobes and chimeric ?PNA probes is especially useful for detecting RNA and telomeric DNA in a cell sample. In particular, the probes can be used to deliver fluorescent dyes to the telomeres, allowing direct visualization of telomeres in cells.
    Type: Grant
    Filed: November 14, 2012
    Date of Patent: March 27, 2018
    Assignees: CARNEGIE MELLON UNIVERSITY, UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Bruce A. Armitage, Patricia L. Opresko, Danith Ly, Nathaniel Shank
  • STABILIZED STAT3 DECOY OLIGONUCLEOTIDES AND USES THEREFORE
    Publication number: 20150353613
    Abstract: The present invention is based, at least in part, on novel, unimolecular STAT3 oligonucleotide decoys exhibiting increased in vivo stability as compared to previously known decoys which are effective in inhibiting STAT3 when administered systemically. The invention is also based on pharmaceutical compositions comprising these unimolecular decoys, and methods for using these decoys in the treatment of cancer.
    Type: Application
    Filed: June 15, 2015
    Publication date: December 10, 2015
    Inventors: JENNIFER R. GRANDIS, Daniel Johnson, Danith Ly
  • GAMMA-PNA MINIPROBES FOR FLUORESCENT LABELING
    Publication number: 20150197793
    Abstract: A category of ?PNA miniprobes and chimeric ?PNA probes is especially useful for detecting RNA and telomeric DNA in a cell sample. In particular, the probes can be used to deliver fluorescent dyes to the telomeres, allowing direct visualization of telomeres in cells.
    Type: Application
    Filed: November 14, 2012
    Publication date: July 16, 2015
    Inventors: Bruce A. Armitage, Patricia L. Opresko, Danith Ly, Nathaniel Shank
  • METHOD FOR ENHANCING TRANSPORT OF SEMICONDUCTOR NANOCRYSTALS ACROSS BIOLOGICAL MEMBRANES
    Publication number: 20150198606
    Abstract: Semiconductor nanoparticle complexes comprising semiconductor nanoparticles in association with cationic polymers are described. Also described are methods for enhancing the transport of semiconductor nanoparticles across biological membranes to provide encoded cells. The methods are particularly useful in multiplex settings where a plurality of encoded cells are to be assayed. Kits comprising reagents for performing such methods are also provided.
    Type: Application
    Filed: January 22, 2015
    Publication date: July 16, 2015
    Inventors: Marcel BRUCHEZ, R. Daniels, Jennifer Dias, Larry Mattheakis, Hongjian Liu, Aquanette Burt, Berndt Lagerholm, Danith Ly
  • Stabilized STAT3 decoy oligonucleotides and uses therefore
    Patent number: 9062121
    Abstract: The present invention is based, at least in part, on novel, unimolecular STAT3 oligonucleotide decoys exhibiting increased in vivo stability as compared to previously known decoys which are effective in inhibiting STAT3 when administered systemically. The invention is also based on pharmaceutical compositions comprising these unimolecular decoys, and methods for using these decoys in the treatment of cancer.
    Type: Grant
    Filed: April 4, 2014
    Date of Patent: June 23, 2015
    Assignee: University of Pittsburgh—of the Commonwealth System of Higher Education
    Inventors: Jennifer R. Grandis, Daniel Johnson, Danith Ly
  • STABILIZED STAT3 DECOY OLIGONUCLEOTIDES AND USES THEREFORE
    Publication number: 20140314816
    Abstract: The present invention is based, at least in part, on novel, unimolecular STAT3 oligonucleotide decoys exhibiting increased in vivo stability as compared to previously known decoys which are effective in inhibiting STAT3 when administered systemically. The invention is also based on pharmaceutical compositions comprising these unimolecular decoys, and methods for using these decoys in the treatment of cancer.
    Type: Application
    Filed: April 4, 2014
    Publication date: October 23, 2014
    Applicant: University of Pittsburgh - of the Commonwealth System of Higher Education
    Inventors: Jennifer R. Grandis, Daniel Johnson, Danith Ly
  • Stabilized STAT3 decoy oligonucleotides and uses therefor
    Patent number: 8722640
    Abstract: The present invention is based, at least in part, on novel, unimolecular STAT3 oligonucleotide decoys exhibiting increased in vivo stability as compared to previously known decoys which are effective in inhibiting STAT3 when administered systemically. The invention is also based on pharmaceutical compositions comprising these unimolecular decoys, and methods for using these decoys in the treatment of cancer.
    Type: Grant
    Filed: June 7, 2012
    Date of Patent: May 13, 2014
    Inventors: Jennifer R. Grandis, Daniel Johnson, Danith Ly
  • Stabilized Stat3 Decoy Oligonucleotides And Uses Therefor
    Publication number: 20120288536
    Abstract: The present invention is based, at least in part, on novel, unimolecular STAT3 oligonucleotide decoys exhibiting increased in vivo stability as compared to previously known decoys which are effective in inhibiting STAT3 when administered systemically. The invention is also based on pharmaceutical compositions comprising these unimolecular decoys, and methods for using these decoys in the treatment of cancer.
    Type: Application
    Filed: June 7, 2012
    Publication date: November 15, 2012
    Applicants: Carnegie Melton, University of Pittsburgh - Of The Commonwealth System of Higher Education
    Inventors: Jennifer R. Grandis, Daniel Johnson, Danith Ly
  • Method for enhancing transport of semiconductor nanocrystals across biological membranes
    Publication number: 20050059031
    Abstract: Semiconductor nanoparticle complexes comprising semiconductor nanoparticles in association with cationic polymers are described. Also described are methods for enhancing the transport of semiconductor nanoparticles across biological membranes to provide encoded cells. The methods are particularly useful in multiplex settings where a plurality of encoded cells are to be assayed. Kits comprising reagents for performing such methods are also provided.
    Type: Application
    Filed: December 12, 2003
    Publication date: March 17, 2005
    Inventors: Marcel Bruchez, R. Daniels, Jennifer Dias, Larry Mattheakis, Hongjian Liu, Aquanette Burt, Berndt Christoffer, Danith Ly
  • Method for determining a nucleic acid
    Patent number: 6225052
    Abstract: New electron transfer moiety labeled nucleic acid analogue probes are provided that can be used in methods for determining nucleic acids in a sample. The new probes can be prepared using novel monomer subunits in a chemical synthesis route. The nucleic acids can be determined by binding the probe molecules to the nucleic acid and inducing electron transfer within the complex formed. The occurrence of the electron transfer is determined as a measure of the nucleic acid.
    Type: Grant
    Filed: November 21, 1997
    Date of Patent: May 1, 2001
    Assignees: Roche Diagnostics GmbH, Georgia Tech Research Corporation
    Inventors: Hans-Georg Batz, Henrik Frydenlund Hansen, Henrik Orum, Troels Koch, Gary B. Schuster, Bruce A. Armitage, Danith Ly