Patents by Inventor Danmei Dai

Danmei Dai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for synthesizing molybdopterin precursor Z derivatives
    Patent number: 9260462
    Abstract: Provided herein are synthetic methods for preparing a compound of formula (I): Also provided herein are synthetic methods for preparing a compound of formula (XIII): The disclosure also provides useful intermediates, derivatives, prodrugs, and pharmaceutically acceptable salts, solvates and hydrates of the formula (I) and formula (XIII) compounds. These compounds are useful for treating diseases associated with molybdenum cofactor deficiency.
    Type: Grant
    Filed: February 17, 2012
    Date of Patent: February 16, 2016
    Assignee: Alexion Pharmaceuticals, Inc.
    Inventors: Xiangtian Long, Danmei Dai, Andreas Brunner, Derek Kevin Watt, Keith Clinch, Sylvia Myrna Baars, Rachel Anne Dixon, Gillian Mary Little, Cyrille Abel Sébastien Landreau, Nicolas Georges Rene Proisy
  • Methods for synthesizing molybdopterin precursor Z derivatives
    Publication number: 20140323726
    Abstract: Provided herein are synthetic methods for preparing a compound of formula (I): Also provided herein are synthetic methods for preparing a compound of formula (XIII): The disclosure also provides useful intermediates, derivatives, prodrugs, and pharmaceutically acceptable salts, solvates and hydrates of the formula (I) and formula (XIII) compounds. These compounds are useful for treating diseases associated with molybdenum cofactor deficiency.
    Type: Application
    Filed: February 17, 2012
    Publication date: October 30, 2014
    Applicant: ALEXION PHARMA INTERNATIONAL SÀRL
    Inventors: Xiangtian Long, Danmei Dai, Andreas Brunner, Derek Kevin Watt, Keith Clinch, Sylvia Myrna Baars, Rachel Anne Dixon, Gillian Mary Little, Cyrille Abel Sébastien Landreau, Nicolas Georges Rene Proisy
  • Methods for Synthesizing Molybdopterin Precursor Z Derivatives
    Publication number: 20140303367
    Abstract: Provided herein are synthetic methods for preparing a compound of formula (I): Also provided herein are synthetic methods for preparing a compound of formula (XIII): The disclosure also provides useful intermediates, derivatives, prodrugs, and pharmaceutically acceptable salts, solvates and hydrates of the formula (I) and formula (XIII) compounds. These compounds are useful for treating diseases associated with molybdenum cofactor deficiency.
    Type: Application
    Filed: March 7, 2014
    Publication date: October 9, 2014
    Applicant: Alexion Pharma International Sàrl
    Inventors: Xiangtian Long, Danmei Dai, Andreas Brunner, Derek Kevin Watt, Keith Clinch, Sylvia Myrna Baars, Rachel Anne Dixon, Gillian Mary Little, Cyrille Abel Sébastien Landreau, Nicolas George Rene Proisy
  • PROCESS FOR PREPARING 2-ALKYL-3-AROYL-5-NITRO-BENZOFURANS
    Publication number: 20110178314
    Abstract: The present invention relates to a process for the preparation of a compound of formula wherein R1 is selected from C1-6-alkyl, C3-6-cycloalkyl and aralkyl, and wherein R2 at each occurrence independently is halogen or C1-6-alkyl, and m is an integer from 0 to 4, Q is selected from halogen, —NO2 and —NR3R4, wherein R3 and R4 are independently selected from hydrogen, C1-6-alkyl, C3-6-cycloalkyl, aryl, aralkyl, mesyl and tosyl, or wherein R3 and R4 together form a C4-6-alkylene group, Y at each occurrence is hydrogen or a hydroxy protection group W that can be hydrolytically cleaved under acidic conditions, and n is an integer from 1 to 3, and n is an integer from 1 to 3, with the proviso that n and m together are not greater than 5.
    Type: Application
    Filed: October 10, 2008
    Publication date: July 21, 2011
    Inventors: Alain Wellig, Jean-Paul Roduit, Danmei Dai, Rongmin Chen