Patents by Inventor Danny P. C. McGee

Danny P. C. McGee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of treating cancer with an antibody-drug conjugate
    Patent number: 8034959
    Abstract: The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
    Type: Grant
    Filed: March 2, 2009
    Date of Patent: October 11, 2011
    Assignee: Medarex, Inc.
    Inventors: Howard P. Ng, Zhi-Hong Li, Danny P. C. McGee, Oliver L. Saunders, Guoxian Wu, David John King, Valeri Martichonok, Sharon Elaine Boyd, Thomas J. Lobl
  • Peptidyl prodrugs and linkers and stabilizers useful therefor
    Patent number: 7977465
    Abstract: The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
    Type: Grant
    Filed: March 4, 2009
    Date of Patent: July 12, 2011
    Assignee: Medarex, Inc.
    Inventors: Howard P. Ng, Danny P. C. McGee, Guoxian Wu, Jimmie Moore, Zhi-Hong Li, Sanjeev Gangwar, Oliver L. Saunders, Irina Astafieva
  • PEPTIDYL PRODRUGS AND LINKERS AND STABILIZERS USEFUL THEREFOR
    Publication number: 20090209734
    Abstract: The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
    Type: Application
    Filed: March 4, 2009
    Publication date: August 20, 2009
    Applicant: Medarex, Inc.
    Inventors: Howard P. Ng, Danny P.C. McGee, Guoxian Wu, Jimmie Moore, Zhihong Li, Sanjeev Gangwar, Oliver L. Saunders, Irina Astafieva
  • METHODS OF TREATING CANCER WITH AN ANTIBODY-DRUG CONJUGATE
    Publication number: 20090175888
    Abstract: The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
    Type: Application
    Filed: March 2, 2009
    Publication date: July 9, 2009
    Applicant: Medarex, Inc.
    Inventors: Howard P. Ng, Zhihong Li, Danny P.C. McGee, Oliver L. Saunders, Guoxian Wu, David J. King, Valeri Martichonok, Sharon Boyd, Thomas J. Lobl
  • Peptidyl prodrugs and linkers and stabilizers useful therefor
    Patent number: 7507420
    Abstract: The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
    Type: Grant
    Filed: September 12, 2005
    Date of Patent: March 24, 2009
    Assignee: Medarex, Inc.
    Inventors: Howard P. Ng, Danny P. C. McGee, Guoxian Wu, Jimmie Moore, Zhi-Hong Li, Sanjeev Gangwar, Oliver L. Saunders, Irina Astafieva
  • Disulfide prodrugs and linkers and stabilizers useful therefor
    Patent number: 7498302
    Abstract: The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
    Type: Grant
    Filed: May 20, 2005
    Date of Patent: March 3, 2009
    Assignee: Medarex, Inc.
    Inventors: Howard P. Ng, Zhi-Hong Li, Danny P. C. McGee, Oliver L. Saunders, Guoxian Wu, David J. King, Valeri Martichonok, Sharon Elaine Boyd, Thomas J. Lobl
  • Cytotoxic agents
    Patent number: 7129261
    Abstract: The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
    Type: Grant
    Filed: May 31, 2002
    Date of Patent: October 31, 2006
    Assignee: Medarex, Inc.
    Inventors: Howard P. Ng, Danny P.C. McGee, Oliver L. Saunders, Valeri Martichonok, Guoxian Wu, Zhihong Li, Geoffrey T. Yarranton
  • Peptidyl prodrugs and linkers and stabilizers useful therefor
    Patent number: 7087600
    Abstract: The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
    Type: Grant
    Filed: May 31, 2002
    Date of Patent: August 8, 2006
    Assignee: Medarex, Inc.
    Inventors: Howard P. Ng, Danny P. C. McGee, Guoxian Wu, Jimmie Moore, Zhihong Li, Sanjeev Gangwar, Oliver L. Saunders, Irina Astafieva
  • Disulfide prodrugs and linkers and stabilizers useful therefor
    Patent number: 6989452
    Abstract: The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
    Type: Grant
    Filed: May 31, 2002
    Date of Patent: January 24, 2006
    Assignee: Medarex, Inc.
    Inventors: Howard P. Ng, Zhihong Li, Danny P. C. McGee, Oliver L. Saunders, Guoxian Wu, David J. King, Valeri Martichonok, Sharon Boyd, Thomas J. Lobl
  • Disulfide prodrugs and linkers and stabilizers useful therefor
    Publication number: 20030073852
    Abstract: The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
    Type: Application
    Filed: May 31, 2002
    Publication date: April 17, 2003
    Applicant: Medarex, Inc.
    Inventors: Howard P. Ng, Zhihong Li, Danny P.C. McGee, Oliver L. Saunders, Guoxian Wu, David J. King, Valeri Martichonok, Sharon Boyd, Thomas J. Lobl
  • Peptidyl prodrugs and linkers and stabilizers useful therefor
    Publication number: 20030064984
    Abstract: The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
    Type: Application
    Filed: May 31, 2002
    Publication date: April 3, 2003
    Applicant: MEDAREX, INC.
    Inventors: Howard P. Ng, Danny P. C. McGee, Guoxian Wu, Jimmie Moore, Zhihong Li, Sanjeev Gangwar, Oliver L. Saunders, Irina Astafieva
  • Cytotoxic agents
    Publication number: 20030050331
    Abstract: The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
    Type: Application
    Filed: May 31, 2002
    Publication date: March 13, 2003
    Applicant: Medarex Inc.
    Inventors: Howard P. Ng, Danny P.C. McGee, Oliver L. Saunders, Valeri Martichonok, Guoxian Wu, Zhihong Li, Geoffrey T. Yarranton
  • Peptidyl prodrugs and linkers and stabilizers useful therefor
    Patent number: RE41252
    Abstract: The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
    Type: Grant
    Filed: May 23, 2008
    Date of Patent: April 20, 2010
    Assignee: Medarex, Inc.
    Inventors: Howard P. Ng, Danny P. C. McGee, Guoxian Wu, Jimmie Moore, Zhi-Hong Li, Sanjeev Gangwar, Oliver L. Saunder, Irina Astafieva, Valeri Martichonok