Abstract: Pharmaceutical constructs containing a Peptide Docking Vehicle (PDoV) covalently linked to: (a) a targeting moiety; and (b) a first therapeutic nucleic acid, are provided, where the therapeutic nucleic acid inhibits replication of Hepatitis B virus (HBV). Methods of using the constructs for treating HBV in subjects also are provided.

Abstract: Compositions and methods for development of potent siRNA therapeutics for prevention and treatment of Corona Virus (2019-nCoV; COVID-19) infections are provided. The compositions include a pharmaceutical composition comprising siRNA cocktails that target critical viral genes and pharmaceutically acceptable polymeric nanoparticle carriers and liposomal nanoparticle carriers. Administration methods for prevention and treatment are provided, including airway instillation, subcutaneous injections and nebulizer aerosolization.

Abstract: A slide-over button cover having a front portion to cover a button and a rear portion that slides under a placket of a top layer of a button-down shirt (or other clothing) thereby reducing the stress caused on the thread of a button. The slide-over button cover can have a one- or two-piece construction, or two-piece magnetic construction and can also have a recessed portion under the front portion to accommodate a button.

Abstract: A slide-over button cover having a front portion to cover a button and a rear portion that slides under a placket of a top layer of a button-down shirt (or other clothing) thereby reducing the stress caused on the thread of a button. The slide-over button cover can have a one- or two-piece construction, or two-piece magnetic construction and can also have a recessed portion under the front portion to accommodate a button.

Abstract: A manipulating device suitable for connecting to a body of a portable electronic apparatus is provided, wherein the body has a first connecting unit. The manipulating device includes a manipulating body, a pivotal shaft, a fastener and a second connecting unit. The manipulating body has a button unit including a plurality of keys. The pivotal shaft connects the manipulating body. The fastener connects the pivotal shaft and is pivoted on the manipulating body through the pivotal shaft and is connected to the body. The second connecting unit is disposed at the fastener. When the fastener is connected to the portable electronic apparatus, the second connecting unit connects the first connecting unit.

Abstract: An apparatus, system, and method are disclosed for modeling and optimizing an enterprise application system. The apparatus, in one embodiment, is configured to determine the system processing capacity and workload characteristics. The apparatus is further configured to determine optimization parameters, including the system processor utilization, minimum job acquiring rates for data entry points of the system, and software component multi-parallelism recommendations. A method is disclosed, in one embodiment, to report the optimization parameters and to implement the optimization parameters within the system during run-time.