Patents by Inventor Dante Nardi
Dante Nardi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4968832Abstract: Novel antihypertensive and coronary dilating asymmetric diesters of 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylic acid (or the stereoisomers or pharmaceutically acceptable acid addition salts thereof) have the general formula (I): ##STR1## wherein Ph is phenyl, Ar is 2-nitrophenyl, 3-nitrophenyl, 2,3-dichlorophenyl or benzofurazan-4-yl, A is a straight or branched chain alkylene radical having from 2 to 6 carbon atoms, R is a straight or branched chain alkyl radical having from 1 to 6 carbon atoms, optionally mono-substituted by an alkoxy substituent having from 1 to 6 carbon atoms, R.sub.1 is hydrogen, hydroxy or an alkyl radical having from 1 to 4 carbon atoms, and R.sub.2 is hydrogen or methyl. The subject diesters are facilely prepared from the aldehydes ArCHO and esters of acetoacetic and 3-aminocrotonic acids.Type: GrantFiled: June 28, 1988Date of Patent: November 6, 1990Assignee: Recordati S.A., Chemical and Pharmaceutical CompanyInventors: Giorgio Bianchi, Dante Nardi, Amedeo Leonardo, Gabriel Kraziani
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Patent number: 4940711Abstract: N-piperazinylalkanoylanilides of the formula ##STR1## wherein n is 0, 1 or 2, each of R and R.sub.1 is H or alkyl, and each of R.sub.2, R.sub.3 and R.sub.4 is H, halogen, alkyl, hydroxyalkyl, alkoxy, aralkoxy, alkylthio, aralkylthio, alkylsulphonyl, alkylsulphenyl, NO.sub.2, NH.sub.2, alkylamino, acylamino, ureido, alkylureido, alkylsulphonylamino, CF.sub.3, acyl, CN, COOH, alkoxycarbonyl, NH.sub.2 CO, SO.sub.3 H, guanidinosulphonyl, carbamoyloxy, OH, acyloxy, alkylsulphonyloxy, alkylenedioxy or SO.sub.2 NR.sub.5 R.sub.6 wherein each of R.sub.5 and R.sub.6 is H, alkyl, aryl or acyl and their pharmaceutically acceptable acid addition salts, are antihypertensive agents.Type: GrantFiled: June 30, 1989Date of Patent: July 10, 1990Assignee: Recordati, S.A., Chemical and Pharmaceutical CompanyInventors: Dante Nardi, Amedeo Leonardi, Alberto Catto, Gabriele Graziani
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Patent number: 4806534Abstract: The novel flavonyl-1,4-dihydropyridines having the general formula (I): ##STR1## are therapeutically effective calcium antagonists and smooth muscle relaxant.Type: GrantFiled: October 22, 1986Date of Patent: February 21, 1989Assignee: Recordati S.A., Chemical & Pharmaceutical CompanyInventors: Amedeo Leonardi, Renzo Pennini, Pietro Cazzulani, Dante Nardi
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Patent number: 4772621Abstract: Novel antihypertensive and coronary dilating asymmetric diesters of 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylic acid (or the stereoisomers or pharmaceutically acceptable acid addition salts thereof) have the general formula (I): ##STR1## wherein Ph is phenyl, Ar is 2-nitrophenyl, 3-nitrophenyl, 2,3-dichlorophenyl or benzofurazan-4-yl, A is a straight or branched chain alkylene radical having from 2 to 6 carbon atoms, R is a straight or branched chain alkyl radical having from 1 to 6 carbon atoms, optionally mono-substituted by an alkoxy substituent having from 1 to 6 carbon atoms, R.sub.1 is hydrogen, hydroxy or an alkyl radical having from 1 to 4 carbon atoms, and R.sub.2 is hydrogen or methyl. The subject diesters are facilely prepared from the aldehydes ArCHO and esters of acetoacetic and 3-aminocrotonic acids.Type: GrantFiled: August 19, 1987Date of Patent: September 20, 1988Assignee: Recordati S.A., Chemical and Pharmaceutical CompanyInventors: Dante Nardi, Amedeo Leonardi, Gabriele Graziani, Giorgio Bianchi
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Patent number: 4705797Abstract: Novel antihypertensive and coronary dilating asymmetric diesters of 1,4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylic acid (or the stereoisomers or pharmaceutically acceptable acid addition salts thereof) have the general formula (I): ##STR1## wherein Ph is phenyl, Ar is 2-nitrophenyl, 3-nitrophenyl, 2,3-dichlorophenyl or benzofurazan-4-yl, A is a straight or branched chain alkylene radical having from 2 to 6 carbon atoms, R is a straight or branched chain alkyl radical having from 1 to 6 carbon atoms, optionally mono-substituted by an alkoxy substituent having from 1 to 6 carbon atoms, R.sub.1 is hydrogen, hydroxy or an alkyl radical having from 1 to 4 carbon atoms, and R.sub.2 is hydrogen or methyl. The subject diesters are facilely prepared from the aldehydes ArCHO and esters of acetoacetic and 3-aminocrotonic acids.Type: GrantFiled: February 14, 1985Date of Patent: November 10, 1987Assignee: Recordati S.A., Chemical and Pharmaceutical CompanyInventors: Dante Nardi, Amedeo Leonardi, Gabriele Graziani, Giorgio Bianchi
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Patent number: 4675319Abstract: Novel piperazine derivatives having the general formula: ##STR1## wherein R is hydrogen or lower alkyl, A is straight or branched chain lower alkyl, and R.sub.1 and R.sub.2 are each hydrogen, amino, alkylamino, dialkylamino, mono- or di(hydroxyalkyl)amino, morpholino, pyrrolidino, piperidino, N-alkylpiperazino, 1,3-dithiolan-2-ylidenamino, or N-alkylureido, with the proviso that at least one of R.sub.1 and R.sub.2 is other than hydrogen, or the isomeric mixtures, individual enantiomers or pharmaceutically acceptable acid addition salts thereof, are therapeutically useful antianaphylactic and antibronchospastic agents.Type: GrantFiled: June 9, 1986Date of Patent: June 23, 1987Assignee: Recordati S. A. Chemical and Pharmaceutical CompanyInventors: Dante Nardi, Amedeo Leonardi, Gianni Motta, Pietro Cazzulani
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Patent number: 4634712Type: GrantFiled: May 14, 1985Date of Patent: January 6, 1987Assignee: Recordati S.A.Inventors: Dante Nardi, Amedeo Leonardi, Giorgio Bianchi
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Patent number: 4550115Abstract: Novel 3-methylflavone-8-carboxylates having the structural formula (I): ##STR1## wherein Z is N-methylpiperidinyl, tropinyl or quinuclidinyl, or a group having the structural formula (II): ##STR2## in which n is 0 or 1, R is hydrogen or alkyl having from 1 to 4 carbon atoms, or phenyl, R.sub.1 is hydrogen or alkyl having from 1 to 4 carbon atoms, R.sub.2 is hydrogen or hydroxy, and further wherein R, R.sub.1 and R.sub.2 may together form, with the carbon atoms from which they depend, a cycloalkyl ring having from 4 to 6 carbon atoms, and R.sub.3 is hydrogen or alkyl having from 1 to 4 carbon atoms, with the proviso that R, R.sub.1, R.sub.2 and R.sub.3 cannot at the same time all be hydrogen, and the pharmaceutically acceptable salts thereof, are effective smooth muscle relaxants, calcium blockers, anaesthetics and anti-inflammatories.Type: GrantFiled: July 12, 1982Date of Patent: October 29, 1985Assignee: Recordati S.A., Chemical & Pharmaceutical CompanyInventors: Dante Nardi, Alberto Tajana, Renzo Pennini, Pietro Cazzulani, Gabriele Graziani, Silvano Casadio
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Patent number: 4510140Abstract: The .omega.-[4-(2-pyridyl)-piperazino]-alkanoylanilide compounds having the structural formula (I): ##STR1## wherein n is 1, 2 or 3, each of R, R.sub.1, R.sub.2 R.sub.3, and R.sub.4 is independently hydrogen, halogen, alkyl, alkoxy, OH, NH.sub.2, CF.sub.3, CN, alkylthio, 1-hydroxyalkyl, alkanoyl, NH.sub.2 CO, NH.sub.2 SO.sub.2, alkoxycarbonyl, alkylsulfonyl, benzyloxy, alkanoylamino, NH.sub.2 CONH, 3-phenylureido, 3-alkylureido or alkoxyoxalylamino, R.sub.5 is hydrogen or alkyl, and R.sub.6 is hydrogen or alkoxy, and the pharmaceutically acceptable salts thereof, are effective antianaphylactics, antibronchospastics, antihistaminics, sedatives, analgesics, antiserotonics and blood-pressure-lowering agents.Type: GrantFiled: August 30, 1982Date of Patent: April 9, 1985Assignee: Recordati S.A.Inventors: Dante Nardi, Alberto Catto, Alberto Tajana, Pietro Cazzulani, Gabriele Graziani
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Patent number: 4507308Abstract: The novel anthranilic acid derivatives having the structural formula (I): ##STR1## wherein n is 0, 1 or 2, one of R.sub.1 and R.sub.2 is chloro or trifluoromethyl and the other is hydrogen, and R is 2-oxo-3-oxolanyl or 2-oxo-3-oxazolidinyl, are effective analgesics and anti-inflammatories.Type: GrantFiled: September 28, 1982Date of Patent: March 26, 1985Assignee: Recordati S.A.Inventors: Dante Nardi, Gianni Motta, Rodolfo Testa, Gabriele Graziani, Silvano Casadio
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Patent number: 4482561Abstract: The N-substituted-4-(optionally substituted)-2-, 3- or 4-piperidyl N-(7- or 8-substituted-4-quinolyl)-anthraniloyloxyalkanoates having the structural formula (I): ##STR1## in which R is a straight or branched chain alkyl radical having from 1 to 4 carbon atoms; an alkenyl or alkynyl radical having from 2 to 6 carbon atoms; a benzyl, phenethyl, 4-nitrophenethyl or 4-aminophenethyl radical; or a phenacyl, benzoylethyl, .beta.-hydroxyphenethyl or .alpha.-hydroxyphenylpropyl radical, optionally substituted on the phenyl ring by one or more halogen atom, trifluoromethyl, nitro or amino substituents, or an alkyl substituent having from 1 to 4 carbon atoms or an alkoxy substituent having from 1 to 4 carbon atoms; R.sub.1 is a hydrogen atom or a phenyl radical; each of R.sub.2 and R.sub.3 is independently a hydrogen atom or an alkyl radical having from 1 to 4 carbon atoms; one of R.sub.4 and R.sub.5 is a chlorine atom or a trifluoromethyl radical and the other of R.sub.4 and R.sub.Type: GrantFiled: November 12, 1982Date of Patent: November 13, 1984Assignee: Recordati, S. A., Chemical & Pharmaceutical Co.Inventors: Dante Nardi, Gianni Motta, Rodolfo Testa, Gabriele Graziani
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Patent number: 4438133Abstract: Novel cystine derivatives having the structural formula (I): ##STR1## wherein R is benzyloxycarbonyl or tosyl, and the pharmaceutically acceptable acid addition salts thereof, are effective expectorants and antitussives, and are also effective for the liquescence of respiratory tract fluids.Type: GrantFiled: June 28, 1982Date of Patent: March 20, 1984Assignee: Recordati S.A.Inventors: Dante Nardi, Alberto Tajana, Gianni Motta, Pietro Cazzulani, Gabriele Graziani
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Patent number: 4275071Abstract: Imidazole derivatives of the formula I and pharmaceutically acceptable acid addition salts thereof are provided: ##STR1## In the formula, R.sub.4 1- or 2-naphthyl, optionally substituted with Cl, Br, or I; 1,2,3,4-tetrahydro-6-naphthyl; 3-duryl, optionally 6-substituted by Cl, Br, I, NO.sub.2, CH.sub.3 or benzyl; mesityl, phenyl 2-, 3- or 4-substituted by OH, NH.sub.2, NO.sub.2, CH.sub.3 CONH, phenyl, phenoxy, cyclohexyl, phenylthio, benzylthio, C.sub.1 -C.sub.6 alkyl or C.sub.1 C.sub.6 alkylthio; 4-bibenzylyl; 3,4-dihydroxyphenyl,n=0, 1 or 2 and(a) R=H, alkyl having 1 to 6 carbon atoms or phenyl R.sub.1 =H, alkyl having 1 to 6 carbon atoms or phenyl one of R.sub.2 and R.sub.3 =H the other of R.sub.2 and R.sub.3 =H, OH, benzoyloxy, C.sub.2 -C.sub.7 alkanoyloxy, N-(C.sub.1 -C.sub.6 alkyl)-carbamoyloxy, N,N-[di-(C.sub.1 C.sub.6)alkyl]-carbamoyloxy, but if R.sub.2 =R.sub.3 =H then R=R.sub.1 =H, or(b) R=H, C.sub.1 -C.sub.6 alkyl, phenyl R.sub.1 =H, C.sub.1 -C.sub.6 alkyl, phenyl R.sub.2 +R.sub.Type: GrantFiled: July 10, 1979Date of Patent: June 23, 1981Assignee: Recordati S.A.Inventors: Dante Nardi, Alberto Tajano, Maria J. Magistretti
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Patent number: 4221803Abstract: There are provided 2,4-dichloro-4'-phenyl-.alpha.-(N-imidazolyl-methyl)-dibenzyl ether, 2,4-dichloro-4'-phenylthio-.alpha.-(N-imidazolyl-methyl)-dibenzyl ether and pharmaceutically acceptable acid addition salts thereof. These compounds show activity against some fungi, yeasts and gram positive aerobic and anaerobic bacteria. The new compounds can be prepared by condensing 1-(2',4'-dichlorophenyl)-2-(N-imidazolyl)-ethanol with 4-chloromethyl-biphenyl, 4-bromomethyl-biphenyl, 1-phenylthio-4-chloromethyl-benzene or 1-phenylthio-4-bromomethyl-benzene in a solvent, most preferably dimethylsulphoxide.Type: GrantFiled: May 9, 1979Date of Patent: September 9, 1980Assignee: Recordati, S.A.Inventors: Dante Nardi, Elena Massarani, Alberto Tajana, Mario Veronese
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Patent number: 3933793Abstract: Novel derivatives of 3H-1,5-benzodiazepine and of their salts of addition with acids, including their quaternary ammonium salts, having the general formula: ##EQU1## are provided. Such compounds are effective therapeutically against a large spectrum of gram positive bacteria and APR8 influenza virus. The invention also provides a novel method of preparing compounds having the formula: ##EQU2## wherein R and R' are the same as above, by reacting orthophenylenediamine with a benzoyldithioacetic acid having the formula: ##EQU3## wherein R and R' are as defined above.Type: GrantFiled: October 10, 1972Date of Patent: January 20, 1976Assignee: Recordati S.A. Chemical and Pharmaceutical CompanyInventors: Dante Nardi, Elena Massarani, Ludwig Degen