Patents by Inventor Daphne Bell

Daphne Bell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments
    Publication number: 20080096212
    Abstract: The present invention is directed to a method for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) treatment. In a preferred embodiment, the presence of at least one variance in the kinase domain of the erbB1 gene confers sensitivity to the tyrosine kinase inhibitor gefitinib. Thus, a diagnostic assay for these mutations will allow for the administration of gefitinib, erlotinib and other tyrosine kinase inhibitors to those patients most likely to respond to the drug.
    Type: Application
    Filed: August 20, 2007
    Publication date: April 24, 2008
    Applicants: The General Hospital Corporation, Dana Farber Cancer Institute, Inc.
    Inventors: Daphne Bell, Daniel Haber, Pasi Janne, Bruce Johnson, Thomas Lynch, Matthew Meyerson, Juan Paez, William Sellers, Jeffrey Settleman, Raffaella Sordella
  • Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments
    Publication number: 20060147959
    Abstract: The present invention is directed to a method for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) treatment. In a preferred embodiment, the presence of at least one variance in the kinase domain of the erbB1 gene confers sensitivity to the tyrosine kinase inhibitor gefitinib. Thus, a diagnostic assay for these mutations will allow for the administration of gefitinib, erlotinib and other tyrosine kinase inhibitors to those patients most likely to respond to the drug.
    Type: Application
    Filed: December 5, 2005
    Publication date: July 6, 2006
    Applicants: The General Hospital Corporation, Dana-Farber Cancer Institute, Inc.
    Inventors: Daphne Bell, Daniel Haber, Pasi Janne, Bruce Johnson, Thomas Lynch, Matthew Meyerson, Juan Paez, William Sellers, Jeffrey Settleman, Raffaella Sordella
  • Salvador tumor suppressor gene
    Publication number: 20050089858
    Abstract: The invention relates to the discovery of a novel Drosophila gene, salavador, and to the discovery of a tumor suppressor function for its human counterpart. The salvador nucleic acid and protein molecules, their use in the diagnosis and treatment of disorders characterized by aberrant salvador molecule expression, as well as various research uses are described.
    Type: Application
    Filed: October 25, 2002
    Publication date: April 28, 2005
    Inventors: Iswar Hariharan, Nicholas Tapon, Daniel Haber, Daphne Bell, Doke Wahrer, Kiernan Harvey