Patents by Inventor Darby Thomas

Darby Thomas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FRATAXIN EXPRESSION CONSTRUCTS
    Publication number: 20240000973
    Abstract: The invention provides polynucleotides, vectors and viruses expressing frataxin and methods of treating Friedreich's Ataxia.
    Type: Application
    Filed: July 24, 2023
    Publication date: January 4, 2024
    Inventors: Stephen SCHAUER, Darby THOMAS, Gregory ROBINSON, Mark PYKETT, Richard THORN, Kirsten GRUIS
  • Systems and methods to recommend benefit types of benefit items to offer within a membership platform
    Patent number: 11790391
    Abstract: Systems and methods are provided for recommending benefit types of benefit items to offer within a membership platform.
    Type: Grant
    Filed: March 17, 2020
    Date of Patent: October 17, 2023
    Assignee: PATREON, INC.
    Inventors: Darby Thomas, Jennifer Pugh, Jenna Lee, Nicholas Swanson, Claudia Gold, Elana Koren
  • SYSTEMS AND METHODS TO RECOMMEND BENEFIT TYPES OF BENEFIT ITEMS TO OFFER WITHIN A MEMBERSHIP PLATFORM
    Publication number: 20230245162
    Abstract: Systems and methods are provided for recommending benefit types of benefit items to offer within a membership platform.
    Type: Application
    Filed: April 13, 2023
    Publication date: August 3, 2023
    Inventors: Darby Thomas, Jennifer Pugh, Jenna Lee, Nicholas Swanson, Claudia Gold, Elana Koren
  • RECOMBINANT VIRAL VECTORS AND NUCLEIC ACIDS FOR PRODUCING THE SAME
    Publication number: 20210324418
    Abstract: Described herein are nucleic acids, AAV transfer cassettes and plasmids used in the production of recombinant adeno-associated viral (rAAV) vectors. The disclosed nucleic acids, cassettes and plasmids comprise sequences that express one or more transgenes having therapeutic efficacy in the amelioration, treatment and/or prevention of one or more diseases or disorders.
    Type: Application
    Filed: May 21, 2021
    Publication date: October 21, 2021
    Inventors: Darby Thomas, David Dismuke
  • Frataxin expression constructs
    Patent number: 11116852
    Abstract: The invention provides polynucleotides, vectors and viruses expressing frataxin and methods of treating Friedreich's Ataxia.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: September 14, 2021
    Assignee: PRECIGEN, INC.
    Inventors: Stephen Schauer, Darby Thomas, Gregory Robinson, Mark Pykett, Richard Thorn, Kirsten Gruis
  • FRATAXIN EXPRESSION CONSTRUCTS
    Publication number: 20210177991
    Abstract: The invention provides polynucleotides, vectors and viruses expressing frataxin and methods of treating Friedreich's Ataxia.
    Type: Application
    Filed: December 17, 2020
    Publication date: June 17, 2021
    Inventors: Stephen SCHAUER, Darby THOMAS, Gregory ROBINSON, Mark PYKETT, Richard THORN, Kirsten GRUIS
  • DELIVERY OF AUTOLOGOUS CELLS COMPRISING MATRIX METALLOPROTEINASE FOR TREATMENT OF SCLERODERMA
    Publication number: 20200129561
    Abstract: The present invention relates to a method for the treatment of scleroderma through the delivery of matrix metalloproteinase (MMP) to a patient in need thereof, preferably under the control of a gene switch. In this manner, the use of a ligand activator to activate or deactivate the expression of MMP controls the gene switch. In another embodiment, the invention is directed to the delivery of autologous genetically modified cells transfected/transduced with a polynucleotide encoding MMP under the control of a gene switch activatable through the use of an activator ligand for the treatment or scleroderma.
    Type: Application
    Filed: April 20, 2018
    Publication date: April 30, 2020
    Applicant: Intrexon Corporation
    Inventors: Darby Thomas, John Maslowski, Anna Malyala
  • RECOMBINANT VIRUS PRODUCTION USING MAMMALIAN CELLS IN SUSPENSION
    Publication number: 20180312872
    Abstract: The invention generally provides methods for producing recombinant AAV viral particles using cells grown in suspension. The invention provides recombinant AAV particles for use in methods for delivering genes encoding therapeutic proteins, and methods for using the recombinant AAV particles in gene therapy.
    Type: Application
    Filed: September 7, 2017
    Publication date: November 1, 2018
    Inventors: David R. Knop, Darby Thomas, Gabor Veres
  • FRATAXIN EXPRESSION CONSTRUCTS
    Publication number: 20180140721
    Abstract: The invention provides polynucleotides, vectors and viruses expressing frataxin and methods of treating Friedreich's Ataxia.
    Type: Application
    Filed: November 8, 2017
    Publication date: May 24, 2018
    Applicant: Intrexon Corporation
    Inventors: Stephen SCHAUER, Darby THOMAS, Gregory ROBINSON, Mark PYKETT, Richard THORN, Kirsten GRUIS
  • Recombinant virus production using mammalian cells in suspension
    Patent number: 9783826
    Abstract: The invention generally provides methods for producing recombinant AAV viral particles using cells grown in suspension. The invention provides recombinant AAV particles for use in methods for delivering genes encoding therapeutic proteins, and methods for using the recombinant AAV particles in gene therapy.
    Type: Grant
    Filed: November 21, 2012
    Date of Patent: October 10, 2017
    Assignee: Applied Genetic Technologies Corporation
    Inventors: David R. Knop, Darby Thomas, Gabor Veres
  • RECOMBINANT VIRUS PRODUCTION USING MAMMALIAN CELLS IN SUSPENSION
    Publication number: 20130244331
    Abstract: The invention generally provides methods for producing recombinant AAV viral particles using cells grown in suspension. The invention provides recombinant AAV particles for use in methods for delivering genes encoding therapeutic proteins, and methods for using the recombinant AAV particles in gene therapy.
    Type: Application
    Filed: November 21, 2012
    Publication date: September 19, 2013
    Applicant: Applied Genetic Technologies Corporation
    Inventors: Dave Knop, Darby Thomas, Gabor Veres
  • RECOMBINANT VIRUS PRODUCTION USING MAMMALIAN CELLS IN SUSPENSION
    Publication number: 20110229971
    Abstract: The invention generally provides methods for producing recombinant AAV viral particles using cells grown in suspension. The invention provides recombinant AAV particles for use in methods for delivering genes encoding therapeutic proteins, and methods for using the recombinant AAV particles in gene therapy.
    Type: Application
    Filed: July 13, 2010
    Publication date: September 22, 2011
    Applicant: APPLIED GENETIC TECHNOLOGIES CORPORATION
    Inventors: David Knop, Darby Thomas, Gabor Veres