Patents by Inventor Darcy K. Kelly-Greene
Darcy K. Kelly-Greene has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230313107Abstract: Cartridge for manufacturing a population of cells suitable for formulation as a cellular therapeutic are disclosed herein, along with systems for operating the cartridges and performing methods to generate the population of cells suitable for formulation as a cellular therapeutic. The population of cells suitable for formulation as a cellular therapeutic can be T-cells, including CAR T-cells. The systems and methods can be largely automated.Type: ApplicationFiled: December 28, 2022Publication date: October 5, 2023Applicant: BERKELEY LIGHTS, INC.Inventors: Andrew W. McFarland, Peter J. Beemiller, Guido K. Stadler, Alexander J. Mastroianni, Joshua J. Cardiel Rivera, Darcy K. Kelly-Greene, Jonathan Cloud Dragon Hubbard, Natalie C. Marks, Long Van Le, Ke-Chih Lin
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Publication number: 20230242860Abstract: Incubators including an enclosure with an internal chamber configured to support a cell culture plate comprising a plurality of wells are disclosed. The enclosure includes a plurality of openings configured to allow access to the wells. The incubators include a sealing element configured to seal the plurality of openings in the enclosure. The sealing element comprises a plurality of openings corresponding to at least a subset of the plurality of openings in the enclosure. Access to the internal chamber can be provided by aligning the plurality of openings in the sealing element with the plurality of openings in the enclosure. Methods for using the incubators are also provided.Type: ApplicationFiled: September 29, 2022Publication date: August 3, 2023Inventors: Russell A. NEWSTROM, Andrew W. MCFARLAND, Darcy K. KELLY-GREENE, J. Tanner NEVILL, Gang F. WANG
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Patent number: 11492584Abstract: Incubators including an enclosure with an internal chamber configured to support a cell culture plate comprising a plurality of wells are disclosed. The enclosure includes a plurality of openings configured to allow access to the wells. The incubators include a sealing element configured to seal the plurality of openings in the enclosure. The sealing element comprises a plurality of openings corresponding to at least a subset of the plurality of openings in the enclosure. Access to the internal chamber can be provided by aligning the plurality of openings in the sealing element with the plurality of openings in the enclosure. Methods for using the incubators are also provided.Type: GrantFiled: August 9, 2019Date of Patent: November 8, 2022Assignee: Berkeley Lights, Inc.Inventors: Russell A. Newstrom, Andrew W. McFarland, Darcy K. Kelly-Greene, J. Tanner Nevill, Gang F. Wang
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Publication number: 20220325240Abstract: Cartridges for manufacturing a population of cells suitable for formulation as a cellular therapeutic are disclosed herein, along with systems and instruments for operating the cartridges and performing methods to generate the population of cells suitable for formulation as a cellular therapeutic. The population of cells suitable for formulation as a cellular therapeutic can be immunological cells, such as T lymphocytes, including endogenous T cells (ETCs), tumor infiltrating lymphocytes (TILs), CAR T-cells, TCR engineered T-cells, or otherwise engineered T-cells. The systems and methods can be largely automated.Type: ApplicationFiled: January 12, 2022Publication date: October 13, 2022Inventors: Andrew W. McFarland, Peter J. Beemiller, Guido K. Stadler, Alexander J. Mastroianni, Joshua J. Cardiel Rivera, Darcy K. Kelly-Greene, Jonathan Cloud Dragon Hubbard, Natalie C. Marks, Long Van Le, Ke-Chih Lin
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Patent number: 11434462Abstract: Incubators are disclosed which include an enclosure with an internal chamber configured to support a cell culture plate and provide an environment suitable for maintaining and/or culturing biological cells. The enclosure can include one or more openings configured to allow access to the cell culture plate. The incubators can further include a structure having a plurality of openings configured to be aligned with a corresponding plurality of wells in the cell culture plate, and a sealing element configured to moveably seal the plurality of openings in the structure. The sealing element can comprise a plurality of openings corresponding to at least a subset of the plurality of openings of the structure. Access to the internal chamber can be provided by aligning the plurality of openings in the sealing element with the plurality of openings in the structure. Methods for using the incubators are also provided.Type: GrantFiled: May 31, 2019Date of Patent: September 6, 2022Assignee: Berkeley Lights, Inc.Inventors: Darcy K. Kelly-Greene, Russell A. Newstrom, Andrew W. McFarland, J. Tanner Nevill, Gang F. Wang
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Publication number: 20200171501Abstract: Microfluidic devices having an electrowetting configuration and an optimized droplet actuation surface are provided for processing biological cells, e.g., for use in nucleic acid library preparation and/or synthesis (including amplification). The devices include a dielectric layer, a hydrophobic layer covalently bonded to the dielectric layer, and a first electrode. Methods of nucleic acid library preparation and/or synthesis can involve providing reagents to cells or nucleic acids by merging appropriate droplets on a droplet actuation surface within a water-immiscible organic liquid and can be performed in the presence of appropriate surfactants. The hydrophobic layer features self-associating molecules covalently bonded to a surface of the dielectric layer in a manner that produces a densely-packed monolayer that resists intercalation and or penetration by polar molecules or species.Type: ApplicationFiled: October 23, 2019Publication date: June 4, 2020Applicant: Berkeley Lights, Inc.Inventors: Jason M. McEwen, Magali Soumillon, Shao Ning Pei, Randall D. Lowe, Jr., Samira A. Nedungadi, Volker L.S. Kurz, Jian Gong, Yara X. Mejia Gonzalez, Mckenzi S. Toh, Brian A. Rabkin, Jason C. Briggs, Darcy K. Kelly-Greene, James M. Porter, Jr.
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Publication number: 20200032193Abstract: Incubators including an enclosure with an internal chamber configured to support a cell culture plate comprising a plurality of wells are disclosed. The enclosure includes a plurality of openings configured to allow access to the wells. The incubators include a sealing element configured to seal the plurality of openings in the enclosure. The sealing element comprises a plurality of openings corresponding to at least a subset of the plurality of openings in the enclosure. Access to the internal chamber can be provided by aligning the plurality of openings in the sealing element with the plurality of openings in the enclosure. Methods for using the incubators are also provided.Type: ApplicationFiled: August 9, 2019Publication date: January 30, 2020Inventors: Russell A. NEWSTROM, Andrew W. McFarland, Darcy K. Kelly-Greene, J. Tanner Nevill, Gang F. Wang
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Publication number: 20200017817Abstract: Incubators are disclosed which include an enclosure with an internal chamber configured to support a cell culture plate and provide an environment suitable for maintaining and/or culturing biological cells. The enclosure can include one or more openings configured to allow access to the cell culture plate. The incubators can further include a structure having a plurality of openings configured to be aligned with a corresponding plurality of wells in the cell culture plate, and a sealing element configured to moveably seal the plurality of openings in the structure. The sealing element can comprise a plurality of openings corresponding to at least a subset of the plurality of openings of the structure. Access to the internal chamber can be provided by aligning the plurality of openings in the sealing element with the plurality of openings in the structure. Methods for using the incubators are also provided.Type: ApplicationFiled: May 31, 2019Publication date: January 16, 2020Inventors: Darcy K. KELLY-GREENE, Russell A. Newstrom, Andrew W. McFarland, J. Tanner Nevill, Gang F. Wang
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Patent number: 10407658Abstract: Incubators including an enclosure with an internal chamber configured to support a cell culture plate comprising a plurality of wells are disclosed. The enclosure includes a plurality of openings configured to allow access to the wells. The incubators include a sealing element configured to seal the plurality of openings in the enclosure. The sealing element comprises a plurality of openings corresponding to at least a subset of the plurality of openings in the enclosure. Access to the internal chamber can be provided by aligning the plurality of openings in the sealing element with the plurality of openings in the enclosure. Methods for using the incubators are also provided.Type: GrantFiled: September 30, 2016Date of Patent: September 10, 2019Assignee: Berkeley Lights, Inc.Inventors: Russell A. Newstrom, Andrew W. McFarland, Darcy K. Kelly-Greene, J. Tanner Nevill, Gang F. Wang
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Publication number: 20170114316Abstract: Incubators including an enclosure with an internal chamber configured to support a cell culture plate comprising a plurality of wells are disclosed. The enclosure includes a plurality of openings configured to allow access to the wells. The incubators include a sealing element configured to seal the plurality of openings in the enclosure. The sealing element comprises a plurality of openings corresponding to at least a subset of the plurality of openings in the enclosure. Access to the internal chamber can be provided by aligning the plurality of openings in the sealing element with the plurality of openings in the enclosure. Methods for using the incubators are also provided.Type: ApplicationFiled: September 30, 2016Publication date: April 27, 2017Applicant: Berkeley Lights, Inc.Inventors: Russell A. NEWSTROM, Andrew W. MCFARLAND, Darcy K. KELLY-GREENE, J. Tanner NEVILL, Gang F. WANG
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Patent number: 9588139Abstract: A probe card assembly can comprise a guide plate comprising probe guides for holding probes in predetermined positions. The probe card assembly can also comprise a wiring structure attached to the guide plate so that connection tips of the probes are positioned against and attached to contacts on the wiring structure. The attachment of the guide plate to the wiring structure can allow the wiring structure to expand or contract at a greater rate than the guide plate. The probes can include compliant elements that fail upon high electrical current and thermal stresses located away from the contact tips.Type: GrantFiled: May 5, 2014Date of Patent: March 7, 2017Assignee: FormFactor, Inc.Inventors: Li Fan, Darcy K. Kelly-Greene, Edward J. Milovic, Gensaku Nagai, Mukesh K. Selvaraj, Jim Zhang
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Publication number: 20140327461Abstract: A probe card assembly can comprise a guide plate comprising probe guides for holding probes in predetermined positions. The probe card assembly can also comprise a wiring structure attached to the guide plate so that connection tips of the probes are positioned against and attached to contacts on the wiring structure. The attachment of the guide plate to the wiring structure can allow the wiring structure to expand or contract at a greater rate than the guide plate. The probes can include compliant elements that fail upon high electrical current and thermal stresses located away from the contact tips.Type: ApplicationFiled: May 5, 2014Publication date: November 6, 2014Applicant: FormFactor, Inc.Inventors: Li Fan, Darcy K. Kelly-Greene, Edward J. Milovic, Gensaku Nagai, Mukesh K. Selvaraj, Jim Zhang