Abstract: An absorbent article having a front waist region, a back waist region, and a crotch region extending between and interconnecting the front and back waist regions. The article comprises an outer cover, a body-side liner, an absorbent assembly between the outer cover and the body-side liner, and leg and flap elastic composites including a containment flap portion and a gasket portion. Each of the composites are attached to the liner such that one of the composites is disposed adjacent one side edge of the liner and the other composite is disposed adjacent the other side edge of the liner, each of the composites extend longitudinally from the front waist region to the back waist region, and each of the composites have a deadened portion in the front waist region or the back waist region. The article further includes a waist elastic member extending longitudinally between the deadened portions.

Abstract: An absorbent article having a front waist region, a back waist region, and a crotch region extending between and interconnecting the front and back waist regions. The article comprises an outer cover, a body-side liner, an absorbent assembly between the outer cover and the body-side liner, and leg and flap elastic composites including a containment flap portion and a gasket portion. Each of the composites are attached to the liner such that one of the composites is disposed adjacent one side edge of the liner and the other composite is disposed adjacent the other side edge of the liner, each of the composites extend longitudinally from the front waist region to the back waist region, and each of the composites have a deadened portion in the front waist region or the back waist region. The article further includes a waist elastic member extending longitudinally between the deadened portions.

Abstract: A method of manufacturing a liner/composite web for use in an absorbent article includes joining a leg elastic member to a web moving in a machine direction and joining a flap elastic member to the web. The flap elastic member is spaced from the leg elastic member. The web is folded to form a leg and flap elastics composite including an outer side edge. The web is joined to a substrate to form the liner/composite web. The liner/composite web is joined to a web of material such that the outer side edge of the leg and flap elastics composite is coterminous with one of a pair of laterally opposing side edges of the web of material.

Abstract: The present invention provides methods of preparing 4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropteridin-6(5H)-one and related compounds.

Abstract: The present invention provides methods of preparing 4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropteridin-6(5H)-one and related compounds.

Abstract: A method of manufacturing a liner/composite web for use in an absorbent article includes joining a leg elastic member to a web moving in a machine direction and joining a flap elastic member to the web. The flap elastic member is spaced from the leg elastic member. The web is folded to form a leg and flap elastics composite including an outer side edge. The web is joined to a substrate to form the liner/composite web. The liner/composite web is joined to a web of material such that the outer side edge of the leg and flap elastics composite is coterminous with one of a pair of laterally opposing side edges of the web of material.

Abstract: A method of manufacturing a leg and flap elastics composite for use in an absorbent article includes joining a leg elastic member to a web moving in a machine direction. A flap elastic member is joined to the web and spaced from the leg elastic member. The web is fed to a chopper assembly wherein portions of the leg and flap elastic members are rendered less elastic at spaced-apart intervals to define deadened portions of the leg and flap elastic members.

Abstract: A method of manufacturing a leg and flap elastics composite for use in an absorbent article includes joining a leg elastic member to a web moving in a machine direction. A flap elastic member is joined to the web and spaced from the leg elastic member. The web is fed to a chopper assembly wherein portions of the leg and flap elastic members are rendered less elastic at spaced-apart intervals to define deadened portions of the leg and flap elastic members.

Abstract: Monocyclic aminopropyl tetrahydro-pyrazolo-pyridine compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis.

Abstract: Bicyclic aminopropyl tetrahydro-pyrazolo-pyridine compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis.

Abstract: Biaryl-substituted tetrahydro-pyrazolo-pyridine compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis.

Abstract: A method of accumulating a web includes pivoting subsets of rolls to a generally vertical alignment; moving one set of rolls past the other; passing the web between the sets of rolls; moving one set of rolls past the other to engage the web; pivoting the subsets to a generally horizontal alignment; moving the web alternatively between the subsets; and moving the sets apart to accumulate the web and together to discharge the web. A web accumulator includes at least two sets of rolls. Each set of rolls has subsets of rolls. The subsets have two consecutive staggered rolls. The accumulator has a web path defined by alternating between subsets of the first set and subsets of the second set.

Abstract: A method and apparatus for bonding and aperturing one or more fibrous webs including bonding at least one fibrous web in a bonding nip created by a rotatable bonding roll and a rotatable anvil roll and aperturing the at least one fibrous web in an aperturing nip created by a rotatable aperture roll and an anvil roll. The bonding roll has a plurality of protuberances extending from the peripheral bonding surface that define a bonding pattern and result in highly bonded regions within the fibrous web. The aperture roll has a plurality of projections extending from the peripheral aperture surface that define an aperturing pattern. The aperturing pattern substantially aligns with the bonding pattern thereby creating apertures within the highly bonded regions.

Abstract: The invention provides compounds of Formula I and derivatives thereof, pharmaceutical compositions comprising a compound of Formula I, and methods of treatment utilizing such compounds and compositions: wherein: R1 is chosen from optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, and optionally substituted heteroaralkyl; L is a linker; R2 is chosen from optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, and optionally substituted heteroaralkyl; and or single stereoisomers, mixtures of stereoisomers, or the pharmaceutically acceptable salts, amides, or esters thereof.

Abstract: A system for locking cargo containers. The container locking system comprises a lock housing comprising a box, a lock bar housing disposed behind the lock housing, a lock bar disposed within the lock bar housing, a staple attached to the lock bar, a slot disposed between the lock housing and the lock bar housing, and a lock. The staple translates and rotates as the lock bar translates and rotates. The staple may be disposed in the slot and accessed from an opening in the front of the lock housing. A shackle of the lock may be disposed through a hole in the staple, thus securing the system.

Abstract: The present invention provides novel compounds of the Formula (I): A-B, its prodrug forms, or pharmaceutically acceptable salts thereof, wherein A represents a saturated, unsaturated, or a partially unsaturated bicyclic heterocyclic ring structure, and B represents an aryl or a heteroaryl group. Preferred compounds of the present invention comprise a benzimidazole or indole nucleus. The compounds of this invention are inhibitors of serine proteases, Urokinase (uPA), Factor Xa (FXa), and/or Factor VIIa (FVIIa), and have utility as anti cancer agents and/or as anticoagulants for the treatment or prevention of thromboembolic disorders in mammals.

Abstract: The invention provides compounds of Formula I and derivatives thereof, pharmaceutical compositions comprising a compound of Formula I, and methods of treatment utilizing such compounds and compositions: 1

Abstract: Compounds of formula I: ##STR1## where: R.sub.10 is a group represented by formula (A), (B), or (C): ##STR2## and the other substituents are as defined in the specification; and their pharmaceutically acceptable salts are inhibitors of prostaglandin G/H synthase and are anti-inflammatory and analgesic agents.