Patents by Inventor Darius Francescatti
Darius Francescatti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 8529427Abstract: A device for administering brachytherapy to a patient includes a vessel that may be in the form of a hollow cylindrical cup, for fleshing into and substantially filling the open-ended cavity. The vessel has a closed outer end, which may be a removable cover, and a source guide penetrates the closed outer end so as to extend deep into the vessel, to receive a radiation source in the source guide. A manipulator can be connected to the radiation source, and also to the source guide, for allowing several different types of manipulation of the source orientation and position within the vessel during the brachytherapy procedure.Type: GrantFiled: October 11, 2012Date of Patent: September 10, 2013Assignee: Xoft, Inc.Inventors: Darius Francescatti, James E. Jervis
-
Patent number: 8303476Abstract: A device for administering brachytherapy to a patient includes a vessel that may be in the form of a hollow cylindrical cup, for fleshing into and substantially filling the open-ended cavity. The vessel has a closed outer end, which may be a removable cover, and a source guide penetrates the closed outer end so as to extend deep into the vessel, to receive a radiation source in the source guide. A manipulator can be connected to the radiation source, and also to the source guide, for allowing several different types of manipulation of the source orientation and position within the vessel during the brachytherapy procedure.Type: GrantFiled: May 30, 2008Date of Patent: November 6, 2012Assignee: Xoft, Inc.Inventors: Darius Francescatti, James E. Jervis
-
Patent number: 7914434Abstract: Treatment of lesions in any luminal or organ system of mammalian anatomy is performed using an electronic source of ionizing radiation and aided by an endoscopic or percutaneous approach.Type: GrantFiled: July 3, 2006Date of Patent: March 29, 2011Assignee: Xoft, Inc.Inventors: Darius Francescatti, Paul A. Lovoi
-
Patent number: 7885382Abstract: Methods and apparatus are described for irradiating living tissue via a cavity or lumen, using an inflatable balloon applicator. In a preferred embodiment the applicator balloon has a balloon skin with x-ray contrast material in relatively low concentration, so that an outline of the balloon will appear sharply when imaged externally. In another preferred embodiment the balloon catheter has a drain for withdrawing liquids from the cavity, which may include channels or texture on the exterior of the balloon. Methods are described for using a switchable miniature x-ray tube, variable as to voltage and current, to achieve accuracy in an isodose profile.Type: GrantFiled: June 18, 2007Date of Patent: February 8, 2011Assignee: Xoft, Inc.Inventors: Daren L. Stewart, Paul A. Lovoi, Thomas W. Rusch, Alex Lim, Darius Francescatti
-
Patent number: 7815561Abstract: A breast brachytherapy applicator providing a stable semi permanent/permanent in dwelling platform that is configured to replicate anatomically the excised cancer bed and allows for a more precise anatomically correct delivery of limited field radiation treatment. This device may be used to reconstitute a resected tissue space to its pre-operative size and shape to 1) facilitate the accurate and precise delivery of adjunctive breast brachytherapy following breast cancer surgery and 2) prevent/decrease post-operative deformity as a result of surgical resection, whether for benign or malignant disease, and in particular after radiation treatment of malignant disease in the post lumpectomy patient.Type: GrantFiled: December 19, 2003Date of Patent: October 19, 2010Assignee: Xoft, Inc.Inventors: Michael R. Forman, Darius Francescatti, Ni Ding
-
Patent number: 7783006Abstract: Methods and apparatus are described for irradiating living tissue via a cavity or lumen, using an inflatable balloon applicator. In a preferred embodiment the applicator balloon has a balloon skin with x-ray contrast material in relatively low concentration, so that an outline of the balloon will appear sharply when imaged externally. In another preferred embodiment the balloon catheter has a drain for withdrawing liquids from the cavity, which may include channels or texture on the exterior of the balloon. Methods are described for using a switchable miniature x-ray tube, variable as to voltage and current, to achieve accuracy in an isodose profile.Type: GrantFiled: October 8, 2004Date of Patent: August 24, 2010Assignee: Xoft, Inc.Inventors: Daren L. Stewart, Paul A. Lovoi, Thomas W. Rusch, Alex Lim, Darius Francescatti
-
Patent number: 7744521Abstract: A customized gynecological brachytherapy applicator is formed by placing a molded balloon, which is secured to a handle, into a vaginal cavity and then filling the mold balloon with a settable liquid material. The material may be an expanding foam or any other form of curable material that becomes solid, rigid or pliable, when set by chemical action, temperature change, oxidation, a curing means such as a light, or other curing regime. The mold balloon can be elastic or inelastic, depending on the degree to which the applicator is to conform its external surfaces to the vaginal contours. One or more lumina are provided in the set filler material to receive a radiation source, with additional lumina optionally provided for purposes such as drainage or administration of therapeutic agents. The applicator may be withdrawn and reinserted into the vagina during treatment, and selected tissues adjacent to the applicator are irradiated in accordance with a radiation prescription.Type: GrantFiled: May 21, 2007Date of Patent: June 29, 2010Assignee: Xoft, Inc.Inventors: Darius Francescatti, Paul A. Lovoi
-
Patent number: 7727137Abstract: Methods and applicator apparatus are disclosed for brachytherapy treatment of tissue surrounding a cavity in a patient, particularly a resection cavity. In treatment regimes requiring recovery time between successive radiation treatments, applicators of the invention are retained under the skin, with the skin allowed to at least partially heal, and are re-accessed later for one or more subsequent treatments. To reduce patient discomfort an anesthetic agent can be infused through the applicator to patient tissue, for insertion, balloon inflation or removal of the applicator.Type: GrantFiled: October 11, 2007Date of Patent: June 1, 2010Assignee: Xoft, Inc.Inventors: Darius Francescatti, David J. Hoffmann, Scott Tremberth, Michael Klein, Paul A. Lovoi, James E. Jervis
-
Patent number: 7726318Abstract: A flexible, relatively flat and thin patch, optionally made of biodegradable material, substantially attenuates ionizing radiation from normal but sensitive anatomy during radio-therapy, particularly breast brachytherapy. The patch is of such a thickness as to substantially attenuate radiation by distance or consists of a material that has been formulated with radio-attenuating filler or is of radio-attenuating material. An alternative version consists of a thin patch that is coated with radio-attenuating material.Type: GrantFiled: March 20, 2006Date of Patent: June 1, 2010Assignee: Xoft, Inc.Inventors: Darius Francescatti, Michael Forman
-
Patent number: 7678040Abstract: A customized gynecological brachytherapy applicator is formed by placing a molded balloon, which is secured to a handle, into a vaginal cavity and then filling the mold balloon with a settable liquid material. The material may be an expanding foam or any other form of curable material that becomes solid, rigid or pliable, when set by chemical action, temperature change, oxidation, a curing means such as a light, or other curing regime. The mold balloon can be elastic or inelastic, depending on the degree to which the applicator is to conform its external surfaces to the vaginal contours. One or more lumina are provided in the set filler material to receive a radiation source, with additional lumina optionally provided for purposes such as drainage or administration of therapeutic agents. The applicator may be withdrawn and reinserted into the vagina during treatment, and selected tissues adjacent to the applicator are irradiated in accordance with a radiation prescription.Type: GrantFiled: May 31, 2007Date of Patent: March 16, 2010Assignee: Xoft, Inc.Inventors: Darius Francescatti, Paul A. Lovoi
-
Publication number: 20090299124Abstract: A device for administering brachytherapy to a patient includes a vessel that may be in the form of a hollow cylindrical cup, for fleshing into and substantially filling the open-ended cavity. The vessel has a closed outer end, which may be a removable cover, and a source guide penetrates the closed outer end so as to extend deep into the vessel, to receive a radiation source in the source guide. A manipulator can be connected to the radiation source, and also to the source guide, for allowing several different types of manipulation of the source orientation and position within the vessel during the brachytherapy procedure.Type: ApplicationFiled: May 30, 2008Publication date: December 3, 2009Inventors: Darius Francescatti, James E. Jervis
-
Publication number: 20090209802Abstract: Methods and applicator apparatus are disclosed for brachytherapy treatment of tissue surrounding a cavity in a patient, particularly a resection cavity. In treatment regimes requiring recovery time between successive radiation treatments, applicators of the invention are retained under the skin, with the skin allowed to at least partially heal, and are re-accessed later for one or more subsequent treatments. To reduce patient discomfort an anesthetic agent can be infused through the applicator to patient tissue, for insertion, balloon inflation or removal of the applicator.Type: ApplicationFiled: October 11, 2007Publication date: August 20, 2009Inventors: Darius Francescatti, David J. Hoffmann, Scott Tremberth, Michael Klein, Paul A. Lovoi, James E. Jervis
-
Patent number: 7571728Abstract: A system and method to position and orient an excised breast tissue specimen on a support structure in a duplicate anatomic orientation relative to the operated breast is provided. One embodiment of the system includes an anatomically representative map of the breast under investigation. The system allows a surgeon to suture, ink, or otherwise fix the excised specimen on the map in accordance to its original position and orientation in the operated breast or organ. A radiogram of the excised specimen can be taken that shows the location of calcifications on a grid with radiopaque markers. The system allows a pathologist to cut through the specimen utilizing the map as a template in order to perform histological analysis and correlate the position and orientation of each slice to its anatomic position in the breast and thereby direct a precise and anatomically accurate re-excision by the surgeon if so required.Type: GrantFiled: April 8, 2004Date of Patent: August 11, 2009Assignee: Xoft, Inc.Inventors: Michael R. Forman, Darius Francescatti
-
Publication number: 20080300445Abstract: A customized gynecological brachytherapy applicator is formed by placing a molded balloon, which is secured to a handle, into a vaginal cavity and then filling the mold balloon with a settable liquid material. The material may be an expanding foam or any other form of curable material that becomes solid, rigid or pliable, when set by chemical action, temperature change, oxidation, a curing means such as a light, or other curing regime. The mold balloon can be elastic or inelastic, depending on the degree to which the applicator is to conform its external surfaces to the vaginal contours. One or more lumina are provided in the set filler material to receive a radiation source, with additional lumina optionally provided for purposes such as drainage or administration of therapeutic agents. The applicator may be withdrawn and reinserted into the vagina during treatment, and selected tissues adjacent to the applicator are irradiated in accordance with a radiation prescription.Type: ApplicationFiled: May 31, 2007Publication date: December 4, 2008Inventors: Darius Francescatti, Paul A. Lovoi
-
Publication number: 20080293994Abstract: A customized gynecological brachytherapy applicator is formed by placing a molded balloon, which is secured to a handle, into a vaginal cavity and then filling the mold balloon with a settable liquid material. The material may be an expanding foam or any other form of curable material that becomes solid, rigid or pliable, when set by chemical action, temperature change, oxidation, a curing means such as a light, or other curing regime. The mold balloon can be elastic or inelastic, depending on the degree to which the applicator is to conform its external surfaces to the vaginal contours. One or more lumina are provided in the set filler material to receive a radiation source, with additional lumina optionally provided for purposes such as drainage or administration of therapeutic agents. The applicator may be withdrawn and reinserted into the vagina during treatment, and selected tissues adjacent to the applicator are irradiated in accordance with a radiation prescription.Type: ApplicationFiled: May 21, 2007Publication date: November 27, 2008Inventors: Darius Francescatti, Paul A. Lovoi
-
Publication number: 20080004524Abstract: Treatment of lesions in any luminal or organ system of mammalian anatomy is performed using an electronic source of ionizing radiation and aided by an endoscopic or percutaneous approach.Type: ApplicationFiled: July 3, 2006Publication date: January 3, 2008Inventors: Darius Francescatti, Paul A. Lovoi
-
Publication number: 20080004479Abstract: Methods and apparatus are described for irradiating living tissue via a cavity or lumen, using an inflatable balloon applicator. In a preferred embodiment the applicator balloon has a balloon skin with x-ray contrast material in relatively low concentration, so that an outline of the balloon will appear sharply when imaged externally. In another preferred embodiment the balloon catheter has a drain for withdrawing liquids from the cavity, which may include channels or texture on the exterior of the balloon. Methods are described for using a switchable miniature x-ray tube, variable as to voltage and current, to achieve accuracy in an isodose profile.Type: ApplicationFiled: June 18, 2007Publication date: January 3, 2008Inventors: Daren Stewart, Paul Lovoi, Thomas Rusch, Alex Lim, Darius Francescatti
-
Publication number: 20080004478Abstract: Treatment of lesions in any luminal or organ system of mammalian anatomy is performed using an electronic source of ionizing radiation and aided by an endoscopic or percutaneous approach.Type: ApplicationFiled: July 3, 2006Publication date: January 3, 2008Inventors: Darius Francescatti, Paul A. Lovoi
-
Publication number: 20070219488Abstract: Cavity conforming balloons with active pressure gradients are provided to replace passive reliance on gravity flow of fluid from organs, body lumina, cavities and the like for more accurate and timely assessment and analysis of exudates. Diffuse drug delivery to cavities or lumina can be administered as an adjunct to the drainage process, as can application of brachytherapy.Type: ApplicationFiled: December 15, 2006Publication date: September 20, 2007Inventor: Darius Francescatti
-
Publication number: 20070016179Abstract: A flexible, relatively flat and thin patch, optionally made of biodegradable material, substantially attenuates ionizing radiation from normal but sensitive anatomy during radio-therapy, particularly breast brachytherapy. The patch is of such a thickness as to substantially attenuate radiation by distance or consists of a material that has been formulated with radio-attenuating filler or is of radio-attenuating material. An alternative version consists of a thin patch that is coated with radio-attenuating material.Type: ApplicationFiled: March 20, 2006Publication date: January 18, 2007Inventors: Darius Francescatti, Michael Forman