Patents by Inventor Dariush Norouzian

Dariush Norouzian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Truncated and modified serratiopeptidase and polynucleotides encoding the same
    Patent number: 11499145
    Abstract: A truncated and modified Serratiopeptidase or a variant thereof, and polynucleotides encoding the same. The truncated and modified Serratiopeptidase may have an amino acid sequence including amino acids 1 to 344, and amino acids 1 to 380 of SEQ ID NO: 1. The truncated and modified Serratiopeptidase may further include a first Cysteine (C) residue at a N-terminus of the truncated and modified Serratiopeptidase, substituted for at least one of Alanine 8 and Leucine 12 of SEQ ID NO: 1; and a second Cysteine residue at a C-terminus of the truncated and modified Serratiopeptidase, substituted for at least one of Valine 339 and Arginine 302 of SEQ ID NO: 1. The first and the second Cysteine residues may be adapted to form at least one disulfide bond including at least one of C8-C339, and C12-C302 disulfide bonds between the N-terminus and the C-terminus of the truncated and modified Serratiopeptidase.
    Type: Grant
    Filed: November 17, 2020
    Date of Patent: November 15, 2022
    Inventors: Vahideh Valizadeh, Maryam Rouhani, Dariush Norouzian, Reza Ahangari Cohan, Sara Mola Salehi
  • TRUNCATED AND MODIFIED SERRATIOPEPTIDASE AND POLYNUCLEOTIDES ENCODING THE SAME
    Publication number: 20210062174
    Abstract: A truncated and modified Serratiopeptidase or a variant thereof, and polynucleotides encoding the same. The truncated and modified Serratiopeptidase may have an amino acid sequence including amino acids 1 to 344, and amino acids 1 to 380 of SEQ ID NO: 1. The truncated and modified Serratiopeptidase may further include a first Cysteine (C) residue at a N-terminus of the truncated and modified Serratiopeptidase, substituted for at least one of Alanine 8 and Leucine 12 of SEQ ID NO: 1; and a second Cysteine residue at a C-terminus of the truncated and modified Serratiopeptidase, substituted for at least one of Valine 339 and Arginine 302 of SEQ ID NO: 1. The first and the second Cysteine residues may be adapted to form at least one disulfide bond including at least one of C8-C339, and C12-C302 disulfide bonds between the N-terminus and the C-terminus of the truncated and modified Serratiopeptidase.
    Type: Application
    Filed: November 17, 2020
    Publication date: March 4, 2021
    Applicants: Pasteur Institute of Iran
    Inventors: Vahideh Valizadeh, Maryam Rouhani, Dariush Norouzian, Reza Ahangari Cohan, Sara Mola Salehi