Patents by Inventor Darrell C. Conklin

Darrell C. Conklin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel FGF homolog zFGF10
    Publication number: 20020031805
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zFGF10, a novel member of the FGF family. The present invention also includes antibodies to the zFGF10 polypeptides, and methods of using the polynucleotides and polypeptides to stimulating growth of cells from the mesenchymal lineage.
    Type: Application
    Filed: December 28, 2000
    Publication date: March 14, 2002
    Inventor: Darrell C. Conklin
  • Follistatin-related protein zfsta2
    Patent number: 6355788
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zfsta2, a novel member of the follistatin family. The polypeptides, and polynucleotides encoding them are useful for binding to members of the TGF-&bgr; family and mediating central nervous system, reproductive, hematopoietic and bone-related activities. The present invention also includes antibodies to the zfsta2 polypeptides.
    Type: Grant
    Filed: October 5, 1999
    Date of Patent: March 12, 2002
    Assignee: ZymoGenetics, Inc.
    Inventors: Darrell C. Conklin, Jeff L. Ellsworth
  • FGF Homologs
    Patent number: 6352971
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zFGF-5 a novel member of the FGF family. The polypeptides, and polynucleotides encoding them, are proliferative for muscle cells and may be used for remodelling cardiac tissue and improving cardiac function. The present invention also includes antibodies to the zFGF-5 polypeptides.
    Type: Grant
    Filed: August 5, 1999
    Date of Patent: March 5, 2002
    Assignee: ZymoGenetics, Inc.
    Inventors: Theresa A. Deisher, Darrell C. Conklin, Fenella Raymond, Thomas R. Bukowski, Susan D. Holderman, Birgit Hansen, Paul O. Sheppard
  • Helical protein zalpha51
    Publication number: 20020009775
    Abstract: Novel four-helix bundle polypeptides, materials and methods for making them, and method of use are disclosed. The polypeptides comprise at least nine contiguous amino acid residues of SEQ ID NO:2 and SEQ ID NO: 5, and may be prepared as polypeptide fusions comprise heterologous sequences, such as affinity tags. The polypeptides and polynucleotides encoding them may be used within a variety of therapeutic, diagnostic, and research applications.
    Type: Application
    Filed: March 16, 2001
    Publication date: January 24, 2002
    Inventors: Darrell C. Conklin, Scott R. Presnell
  • Interferon-&egr;
    Patent number: 6329175
    Abstract: Interferons represent an important class of biopharmaceutical products, which have a proven track record in the treatment of a variety of medical conditions, including the treatment of certain autoimmune diseases, the treatment of particular cancers, and the enhancement of the immune response against infectious agents. To date, four types of interferons have been found in humans: interferon-&agr;, interferon-&bgr;, interferon-&ggr;, and interferon-&ohgr;. The present invention provides new forms of human and murine interferon, “interferon-&egr;,” which have applications in diagnosis and therapy.
    Type: Grant
    Filed: September 16, 1999
    Date of Patent: December 11, 2001
    Assignee: ZymoGenetics, Inc.
    Inventors: Darrell C. Conklin, Francis J. Grant, Mark W. Rixon, Wayne Kindsvogel
  • Human ribonuclease
    Publication number: 20010049434
    Abstract: Although ribonucleases are characterized by the hydrolysis of RNA, these enzymes perform many functions, including anti-parasitic activity, anti-bacterial activity, and anti-viral activity. Ribonucleases are also known to possess anti-neoplastic activity, and angiogenesis-stimulating activity. “Zrnase1” is a new member of the human ribonuclease family.
    Type: Application
    Filed: March 7, 2001
    Publication date: December 6, 2001
    Inventor: Darrell C. Conklin
  • Novel FGF Homolog zFGF12
    Publication number: 20010044525
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zFGF12 a novel member of the FGF family. The present invention also includes antibodies to the zFGF12 polypeptides, and methods of using the polynucleotides and polypeptides.
    Type: Application
    Filed: January 4, 2001
    Publication date: November 22, 2001
    Inventor: Darrell C. Conklin
  • Nucleic acids encoding mammalian alpha helical protein-1
    Patent number: 6303770
    Abstract: Novel mammalian alpha helical polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods including antibodies and anti-idiotypic antibodies.
    Type: Grant
    Filed: December 10, 1998
    Date of Patent: October 16, 2001
    Assignee: ZymoGenetics, Inc.
    Inventors: Si Lok, Darrell C. Conklin, Julia E. Parrish
  • Disulfide core polypeptides
    Patent number: 6239254
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for a disulfide core protein (Zdsc1). The polypeptides, and polynucleotides encoding them, are serine proteinase inhibitors. Also disclosed are expression vectors containing polynucleotides which encode a Zdsc1 polypeptide, antibodies which specifically bind to Zdsc1 polypeptides and anti-idiotypic antibodies which neutralize the antibodies which specifically bind to Zdsc1 polypeptides.
    Type: Grant
    Filed: June 4, 1999
    Date of Patent: May 29, 2001
    Assignee: ZymoGenetics, Inc.
    Inventor: Darrell C. Conklin
  • Kunitz domain polypeptide and materials and methods for making it
    Patent number: 6232098
    Abstract: Proteinase inhibitors comprising a Kunitz domain are disclosed. The Kunitz domain comprises a sequence of amino acid residues as shown in SEQ ID NO:5, wherein the sequence is at least 90% identical to SEQ ID NO:2. Also disclosed are methods for making the proteinase inhibitors, and expression vectors and cultured cells that are useful within the methods. The proteinase inhibitors may be used as components of cell culture media, in protein purification, and in certain therapeutic and diagnostic applications.
    Type: Grant
    Filed: March 10, 2000
    Date of Patent: May 15, 2001
    Assignee: ZymoGenetics, Inc.
    Inventors: Darrell C. Conklin, Donald C. Foster, Zeren Gao
  • Testis-specific insulin homolog polypeptides
    Patent number: 6183991
    Abstract: The present invention provides testis-specific insulin homolog polypeptides and polynucleotides encoding the polypeptides, as well as related compositions and methods are disclosed. The polypeptides and polynucleotides may be used within methods for enhancing viability of cryopreserved sperm, for enhancing sperm motility, to enhance fertilization in methods of assisted reproduction, as contraceptives and other related uses.
    Type: Grant
    Filed: May 18, 1999
    Date of Patent: February 6, 2001
    Assignee: ZymoGenetics, Inc.
    Inventors: Si Lok, Darrell C. Conklin, Robyn L Adams, Anna C. Jelmberg, Catherine E. Lofton-Day, Stephen R. Jaspers
  • Stanniocalcin-2
    Patent number: 6171822
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for stanniocalcin-2, a novel member of the stanniocalcin family. The polypeptides, and polynucleotides encoding them, modulate electrolyte homeostasis. The present invention also includes antibodies to the stanniocalcin-2 polypeptides.
    Type: Grant
    Filed: October 11, 1999
    Date of Patent: January 9, 2001
    Assignee: ZymoGenetics, Inc.
    Inventors: Rolf E. Kuestner, Darrell C. Conklin, Si Lok, Michele Buddle, William Downey
  • Lipocalin homologs
    Patent number: 6143720
    Abstract: The present invention is directed to polynucleotides and polypeptides for a novel member of the lipocalin family. The expression of this novel polynucleotide is restricted to testis and mammary gland, particularly breast tumor tissue. The polypeptide has been designated zlipo1. The present invention also includes antibodies to the zlipo1 polypeptides.
    Type: Grant
    Filed: November 2, 1999
    Date of Patent: November 7, 2000
    Assignee: ZymoGenetics, Inc.
    Inventor: Darrell C. Conklin
  • Methods for stimulating pancreatic islet cell regeneration
    Patent number: 6114307
    Abstract: The present invention provides compositions for stimulating an increase in islet proliferation and .beta.-cell mass using an insulin homolog polypeptide. The present invention also includes methods for treating diabetes by stimulating islet proliferation and .beta.-cell mass increases and affecting insulin levels.
    Type: Grant
    Filed: December 16, 1997
    Date of Patent: September 5, 2000
    Assignee: ZymoGenetics, Inc.
    Inventors: Stephen R. Jaspers, Katherine H. Sprugel, Hong Ping Ren, Jacqueline M. Humes, Darrell C. Conklin
  • Kunitz domain polypeptide and materials and methods for making it
    Patent number: 6087473
    Abstract: Proteinase inhibitors comprising a Kunitz domain are disclosed. The Kunitz domain comprises a sequence of amino acid residues as shown in SEQ ID NO:5, wherein the sequence is at least 90% identical to SEQ ID NO:2. Also disclosed are methods for making the proteinase inhibitors, and expression vectors and cultured cells that are useful within the methods. The proteinase inhibitors may be used as components of cell culture media, in protein purification, and in certain therapeutic and diagnostic applications.
    Type: Grant
    Filed: May 26, 1999
    Date of Patent: July 11, 2000
    Assignee: ZymoGenetics, Inc.
    Inventors: Darrell C. Conklin, Donald C. Foster, Zeren Gao
  • Polynucleotides encoding insulin homolog zins3
    Patent number: 6046028
    Abstract: The present invention relates to polynucleotides encoding for novel insulin homolog polypeptides that have been designated Zins3. The human and mouse polynucleotides and corresponding polypeptides are described, and comprise a B chain, A chain, and C-peptide, or portions thereof. The polynucleotide sequence maps to human chromosome 12.
    Type: Grant
    Filed: October 15, 1997
    Date of Patent: April 4, 2000
    Assignee: ZymoGenetics, Inc.
    Inventors: Darrell C. Conklin, Catherine E. Lofton-Day, Si Lok, Stephen R. Jaspers
  • Lipocalin homolog
    Patent number: 6020163
    Abstract: The present invention is directed to polynucleotides and polypeptides for a novel member of the lipocalin family. The expression of this novel polynucleotide is restricted to testis and mammary gland, particularly breast tumor tissue. The polypeptide has been designated zlipo1. The present invention also includes antibodies to the zlipo1 polypeptides.
    Type: Grant
    Filed: August 6, 1998
    Date of Patent: February 1, 2000
    Assignee: ZymoGenetics, Inc.
    Inventor: Darrell C. Conklin
  • Stanniocalcin-2
    Patent number: 6008322
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for stanniocalcin-2, a novel member of the stanniocalcin family. The polypeptides, and polynucleotides encoding them, modulate electrolyte homeostasis. The present invention also includes antibodies to the stanniocalcin-2 polypeptides.
    Type: Grant
    Filed: April 1, 1997
    Date of Patent: December 28, 1999
    Assignee: ZymoGenetics, Inc.
    Inventors: Rolf E. Kuestner, Darrell C. Conklin, Si Lok, Michele Buddle, William Downey
  • FGF homologs
    Patent number: 5989866
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zFGF-5 a novel member of the FGF family. The polypeptides, and polynucleotides encoding them, are proliferative for muscle cells and may be used for remodelling cardiac tissue and improving cardiac function. The present invention also includes antibodies to the zFGF-5 polypeptides.
    Type: Grant
    Filed: October 16, 1997
    Date of Patent: November 23, 1999
    Assignee: ZymoGenetics, Inc.
    Inventors: Theresa A. Deisher, Darrell C. Conklin, Fenella Raymond, Thomas R. Bukowski, Susan D. Holderman, Birgit Hansen, Paul O. Sheppard
  • Testis-specific insulin homolog polypeptides
    Patent number: 5959075
    Abstract: The present invention provides testis-specific insulin homolog polypeptides and polynucleotides encoding the polypeptides, as well as related compositions and methods are disclosed. The polypeptides and polynucleotides may be used within methods for enhancing viability of cryopreserved sperm, for enhancing sperm motility, to enhance fertilization in methods of assisted reproduction, as contraceptives and other related uses.
    Type: Grant
    Filed: August 1, 1997
    Date of Patent: September 28, 1999
    Assignee: ZymoGenetics, Inc.
    Inventors: Si Lok, Darrell C. Conklin, Robyn L Adams, Anna C. Jelmberg, Catherine E. Lofton-Day, Stephen R. Jaspers