Patents by Inventor Darrell Koza

Darrell Koza has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 7-substituted tetracycline compounds
    Patent number: 8492365
    Abstract: The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Grant
    Filed: June 9, 2009
    Date of Patent: July 23, 2013
    Assignees: Trustees of Tufts College, Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Mohamed Ismail, Todd Bowser, Beena Bhatia, David Messersmith, Laura McIntyre, Darrell Koza, Glen Rennie, Paul Sheahan, Paul Hawkins, Atul Verma, Tadeusz Warchol, Upul Bandarage
  • 7-Phenyl-Substituted Tetracycline Compounds
    Publication number: 20110082305
    Abstract: 7-phenyl-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-phenyl-substituted tetracycline compounds are described.
    Type: Application
    Filed: December 14, 2010
    Publication date: April 7, 2011
    Applicant: Trustees of Tufts College
    Inventors: Mark L. Nelson, Glen Rennie, Darrell Koza
  • 7-phenyl-substituted tetracycline compounds
    Patent number: 7851460
    Abstract: 7-phenyl-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-phenyl-substituted tetracycline compounds are described.
    Type: Grant
    Filed: April 17, 2009
    Date of Patent: December 14, 2010
    Assignee: Trustees of Tufts College
    Inventors: Mark L. Nelson, Glen Rennie, Darrell Koza
  • 7-SUBSTITUTED TETRACYCLINE COMPOUNDS
    Publication number: 20090306022
    Abstract: The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: June 9, 2009
    Publication date: December 10, 2009
    Applicants: Trustees of Tufts College, Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Mohamed Ismail, Todd Bowser, Beena Bhatia, David Messersmith, Laura McIntyre, Darrell Koza, Glen Rennie, Paul Sheahan, Paul Hawkins, Atul Verma, Tadeusz Warchol, Upul Bandarage
  • 7-Phenyl-Substituted Tetracycline Compounds
    Publication number: 20090258842
    Abstract: 7-phenyl-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-phenyl-substituted tetracycline compounds are described.
    Type: Application
    Filed: April 17, 2009
    Publication date: October 15, 2009
    Applicant: Trustees of Tufts College
    Inventors: Mark L. Nelson, Glen Rennie, Darrell Koza
  • 7-N-substituted phenyl tetracycline compounds
    Publication number: 20090124583
    Abstract: 7-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted tetracycline compounds are described.
    Type: Application
    Filed: May 30, 2008
    Publication date: May 14, 2009
    Applicant: Trustees of Tufts College
    Inventors: Mark L. Nelson, Darrell Koza
  • 7-phenyl-substituted tetracycline compounds
    Publication number: 20070155708
    Abstract: 7-phenyl-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-phenyl-substituted tetracycline compounds are described.
    Type: Application
    Filed: February 13, 2007
    Publication date: July 5, 2007
    Applicant: Trustees of Tufts College
    Inventors: Mark Nelson, Glen Rennie, Darrell Koza
  • 7-N-substituted phenyl tetracycline compounds
    Publication number: 20060234988
    Abstract: 7-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted tetracycline compounds are described.
    Type: Application
    Filed: June 14, 2006
    Publication date: October 19, 2006
    Applicant: Trustees of Tufts College
    Inventors: Mark Nelson, Darrell Koza
  • 7, 8 And 9-substituted tetracycline compounds
    Publication number: 20060229282
    Abstract: 7, 8 and 9-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are described.
    Type: Application
    Filed: June 16, 2006
    Publication date: October 12, 2006
    Applicant: Trustees of Tufts College
    Inventors: Mark Nelson, Darrell Koza, Glen Rennie
  • Methods of preparing substituted tetracyclines with transition metal-based chemistries
    Publication number: 20060166946
    Abstract: The present invention relates to novel chemistries which allow for heretofore unobtainable substituted tetracycline compounds which exhibit significant antibacterial activity. The methods disclosed herein utilize reactive tetracycline-based precursor compounds, reactive organic substituent precursors and transition metal catalysts under conditions such that a tetracycline compound substituted with the desired organic substituent is formed. In one embodiment of the invention, a substituted tetracycline compound may be prepared by combining a reactive tetracycline-based precursor compound such as an arene tetracycline diazonium salt, and a reactive organic substituent precursor, e.g., alkenes, substituted alkenes, vinyl monomers, aromatics and heteroaromatics, in the presence of a transition metal catalyst, such as palladium chloride, under conditions such that a tetracycline compound substituted with the organic substituent is formed.
    Type: Application
    Filed: March 28, 2006
    Publication date: July 27, 2006
    Applicant: Trustees of Tufts College
    Inventors: Mark Nelson, Glen Rennie, Darrell Koza
  • Methods of preparing substituted tetracyclines with transition metal-based chemistries
    Publication number: 20050187198
    Abstract: The present invention relates to novel chemistries which allow for heretofore unobtainable substituted tetracycline compounds which exhibit significant activity in tetracycline responsive states. The methods disclosed herein utilize reactive tetracycline-based precursor compounds, reactive organic substituent precursors and transition metal catalysts under conditions such that a tetracycline compound substituted with the desired organic substituent is formed. In one embodiment of the invention, a substituted tetracycline compound may be prepared by combining a reactive tetracycline-based precursor compound such as an arene tetracycline diazonium salt, and a reactive organic substituent precursor, e.g., alkenes, substituted alkenes, vinyl monomers, aromatics and heteroaromatics, in the presence of a transition metal catalyst, such as palladium chloride, under conditions such that a tetracycline compound substituted with the organic substituent is formed.
    Type: Application
    Filed: December 3, 2004
    Publication date: August 25, 2005
    Applicant: Trustees of Tufts College
    Inventors: Mark Nelson, Glen Rennie, Darrell Koza
  • 7, 8 and 9-substituted tetracycline compounds
    Publication number: 20050148551
    Abstract: 7, 8 and 9-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are described.
    Type: Application
    Filed: June 10, 2004
    Publication date: July 7, 2005
    Applicant: Trustees of Tufts College
    Inventors: Mark Nelson, Darrell Koza, Glen Rennie
  • 7-phenyl-substituted tetracycline compounds
    Publication number: 20050119235
    Abstract: 7-phenyl-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-phenyl-substituted tetracycline compounds are described.
    Type: Application
    Filed: April 5, 2004
    Publication date: June 2, 2005
    Inventors: Mark Nelson, Glen Rennie, Darrell Koza
  • 7-Substituted tetracycline compounds
    Publication number: 20040224928
    Abstract: The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: May 24, 2004
    Publication date: November 11, 2004
    Applicants: Trustees of Tufts College, Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Mohamed Ismail, Todd Bowser, Beena Bhatia, David Messersmith, Laura McIntyre, Darrell Koza, Glen Rennie, Paul Sheahan, Paul Hawkins, Atul Verma, Tadeusz Warchol, Upul Bandarage
  • 9-Substituted minocycline compounds
    Publication number: 20040214801
    Abstract: The present invention pertains, at least in part, to novel 9- substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: May 4, 2004
    Publication date: October 28, 2004
    Applicants: Paratek Pharmaceuticals, Inc., Trustees of Tufts College
    Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Mohamed Ismail, Todd Bowser, Jimmy Dumornay, Glen Rennie, Gui Liu, Darrell Koza, Paul Sheahan, Karen Stapleton, Paul Hawkins, Beena Bhatia, Atul K. Verma, Laura McIntyre, Tadeusz Warchol, David Messersmith
  • 7,8 and 9-substituted tetracycline compounds
    Patent number: 6624168
    Abstract: 7, 8 and 9-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are described.
    Type: Grant
    Filed: June 29, 2001
    Date of Patent: September 23, 2003
    Assignee: Trustees of Tufts College
    Inventors: Mark L. Nelson, Darrell Koza
  • 9-substituted minocycline compounds
    Publication number: 20030125348
    Abstract: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: June 29, 2001
    Publication date: July 3, 2003
    Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Mohamed Ismail, Todd Bowser, Jimmy Dumornay, Glen Rennie, Gui Liu, Darrell Koza, Paul Sheahan, Karen Stapleton, Paul Hawkins, Beena Bhatia, Atul K. Verma, Laura McIntyre, Tadeusz Warchol, David Messersmith
  • 7-substituted tetracycline compounds
    Publication number: 20030055025
    Abstract: The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: June 29, 2001
    Publication date: March 20, 2003
    Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Mohamed Ismail, Todd Bowser, Beena Bhatia, David Messersmith, Laura McIntyre, Darrell Koza, Glen Rennie, Paul Sheahan, Paul Hawkins, Atul Verma, Tadeusz Warchol, Upul Bandarage
  • 7-phenyl-substituted tetracycline compounds
    Publication number: 20020132798
    Abstract: 7-phenyl-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-phenyl-substituted tetracycline compounds are described.
    Type: Application
    Filed: June 15, 2001
    Publication date: September 19, 2002
    Inventors: Mark L. Nelson, Glen Rennie, Darrell Koza
  • 7-N-substituted phenyl tetracycline compounds
    Publication number: 20020128237
    Abstract: 7-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted tetracycline compounds are described.
    Type: Application
    Filed: June 15, 2001
    Publication date: September 12, 2002
    Inventors: Mark L. Nelson, Darrell Koza