Patents by Inventor Darren Carns
Darren Carns has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200003795Abstract: The present invention relates to compositions and methods for analyzing analytes of interest in liquid samples by mass spectrometry, and preferably in patient samples. Preferred analytes of interest include sirolimus (rapamycin), corticosteroids, bile acids and lamotrigine (lamictal). In one embodiment, by careful selection of target ions, a number of corticosteroids can be analyzed simultaneously and without interference from closely related molecules. In another embodiment, the present methods combine high turbulence liquid chromatography with mass spectrometry performed in positive and negative mode in a single assay to enable the detection and quantification of the composit˜on of bile acid pools. By combining mass spectrometry and high-throughput chromatography, the methods and compositions described herein can provide a rapid, sensitive, and accurate assay for use in large clinical laboratories.Type: ApplicationFiled: September 11, 2019Publication date: January 2, 2020Inventors: Sum CHAN, Richard E. REITZ, Mildred M. GOLDMAN, Seyed A. SADJADI, Michael P. CAUFIELD, Darren A. CARNS
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Patent number: 8409862Abstract: Provided are methods for determining the presence or amount of testosterone in a test sample, comprising ionizing all or a portion of the testosterone present in the sample to produce one or more testosterone ions that are detectable in a mass spectrometer. All or a portion of the testosterone present in the sample is ionized to produce one or more testosterone ions, which may be isolated and fragmented to produce precursor ions. A separately detectable internal testosterone standard can be provided in the sample. In a preferred embodiment, the reference is 2,2,4,6,6-d5 testosterone.Type: GrantFiled: November 15, 2010Date of Patent: April 2, 2013Assignee: Quest Diagnostics Investments IncorporatedInventors: Michael P. Caulfield, Darren A Carns, Richard E Reitz
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Patent number: 8329392Abstract: Provided are methods for determining the presence or amount of testosterone in a test sample, comprising ionizing all or a portion of the testosterone present in the sample to produce one or more testosterone ions that are detectable in a mass spectrometer. All or a portion of the testosterone present in the sample is ionized to produce one or more testosterone ions, which may be isolated and fragmented to produce precursor ions. A separately detectable internal testosterone standard can be provided in the sample. In a preferred embodiment, the reference is 2,2,4,6,6-d5 testosterone.Type: GrantFiled: May 27, 2011Date of Patent: December 11, 2012Assignee: Quest Diagnostics Investments IncorporatedInventors: Michael P. Caulfield, Darren A Carns, Richard E Reitz
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Patent number: 8318418Abstract: Provided are methods for determining the presence or amount of testosterone in a test sample, comprising ionizing all or a portion of the testosterone present in the sample to produce one or more testosterone ions that are detectable in a mass spectrometer. All or a portion of the testosterone present in the sample is ionized to produce one or more testosterone ions, which may be isolated and fragmented to produce precursor ions. A separately detectable internal testosterone standard can be provided in the sample. In a preferred embodiment, the reference is 2,2,4,6,6-d5 testosterone.Type: GrantFiled: October 28, 2009Date of Patent: November 27, 2012Assignee: Quest Diagnostics Investments IncorporatedInventors: Michael P. Caulfield, Darren A Carns, Richard E Reitz
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Publication number: 20110306080Abstract: The present invention relates to compositions and methods for analyzing analytes of interest in liquid samples by mass spectrometry, and preferably in patient samples. Preferred analytes of interest include sirolimus (rapamycin), corticosteroids, bile acids and lamotrigine (lamictal). In one embodiment, by careful selection of target ions, a number of corticosteroids can be analyzed simultaneously and without interference from closely related molecules. In another embodiment, the present methods combine high turbulence liquid chromatography with mass spectrometry performed in positive and negative mode in a single assay to enable the detection and quantification of the composition of bile acid pools. By combining mass spectrometry and high-throughput chromatography, the methods and compositions described herein can provide a rapid, sensitive, and accurate assay for use in large clinical laboratories.Type: ApplicationFiled: May 6, 2011Publication date: December 15, 2011Inventors: Sum Chan, Darren A. Carns, Michael P. Caulfield, Richard E. Reitz, Mildred M. Redor-Goldman, Seyed A. Sadjadi
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Publication number: 20110226946Abstract: Provided are methods for determining the presence or amount of testosterone in a test sample, comprising ionizing all or a portion of the testosterone present in the sample to produce one or more testosterone ions that are detectable in a mass spectrometer. All or a portion of the testosterone present in the sample is ionized to produce one or more testosterone ions, which may be isolated and fragmented to produce precursor ions. A separately detectable internal testosterone standard can be provided in the sample. In a preferred embodiment, the reference is 2,2,4,6,6-d5 testosterone.Type: ApplicationFiled: May 27, 2011Publication date: September 22, 2011Inventors: Michael P. Caulfield, Darren A. Carns, Richard E. Reitz
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Publication number: 20110059534Abstract: Provided are methods for determining the presence or amount of testosterone in a test sample, comprising ionizing all or a portion of the testosterone present in the sample to produce one or more testosterone ions that are detectable in a mass spectrometer. All or a portion of the testosterone present in the sample is ionized to produce one or more testosterone ions, which may be isolated and fragmented to produce precursor ions. A separately detectable internal testosterone standard can be provided in the sample. In a preferred embodiment, the reference is 2,2,4,6,6-d5 testosterone.Type: ApplicationFiled: November 15, 2010Publication date: March 10, 2011Inventors: Michael P. Caulfield, Darren A. Carns, Richard E. Reitz
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Patent number: 7754419Abstract: Provided are methods for determining the presence or amount of testosterone in a test sample, comprising ionizing all or a portion of the testosterone present in the sample to produce one or more testosterone ions that are detectable in a mass spectrometer. All or a portion of the testosterone present in the sample is ionized to produce one or more testosterone ions, which may be isolated and fragmented to produce precursor ions. A separately detectable internal testosterone standard can be provided in the sample. In a preferred embodiment, the reference is 2,2,4,6,6-d5 testosterone.Type: GrantFiled: March 21, 2008Date of Patent: July 13, 2010Assignee: Quest Diagnostics Investments IncorporatedInventors: Michael P. Caulfield, Darren A Carns, Richard E Reitz
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Publication number: 20100047849Abstract: Provided are methods for determining the presence or amount of testosterone in a test sample, comprising ionizing all or a portion of the testosterone present in the sample to produce one or more testosterone ions that are detectable in a mass spectrometer. All or a portion of the testosterone present in the sample is ionized to produce one or more testosterone ions, which may be isolated and fragmented to produce precursor ions. A separately detectable internal testosterone standard can be provided in the sample. In a preferred embodiment, the reference is 2,2,4,6,6-d5 testosterone.Type: ApplicationFiled: October 28, 2009Publication date: February 25, 2010Inventors: Michael P. Caulfield, Darren A. Carns, Richard E. Reitz
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Publication number: 20080166697Abstract: Provided are methods for determining the presence or amount of testosterone in a test sample, comprising ionizing all or a portion of the testosterone present in the sample to produce one or more testosterone ions that are detectable in a mass spectrometer. All or a portion of the testosterone present in the sample is ionized to produce one or more testosterone ions, which may be isolated and fragmented to produce precursor ions. A separately detectable internal testosterone standard can be provided in the sample. In a preferred embodiment, the reference is 2,2,4,6,6-d5 testosterone.Type: ApplicationFiled: March 21, 2008Publication date: July 10, 2008Inventors: Michael P. Caulfield, Darren A. Carns, Richard E. Reitz
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Patent number: 7348137Abstract: Provided are methods for determining the presence or amount of testosterone in a test sample, comprising ionizing all or a portion of the testosterone present in the sample to produce one or more testosterone ions that are detectable in a mass spectrometer. All or a portion of the testosterone present in the sample is ionized to produce one or more testosterone ions, which may be isolated and fragmented to produce precursor ions. A separately detectable internal testosterone standard can be provided in the sample. In a preferred embodiment, the reference is 2,2,4,6,6-d5 testosterone.Type: GrantFiled: October 11, 2005Date of Patent: March 25, 2008Assignee: Quest Diagnostics Investments IncorporatedInventors: Michael P. Caulfield, Darren A Carns, Richard E Reitz
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Publication number: 20060040256Abstract: Provided are methods for determining the presence or amount of testosterone in a test sample, comprising ionizing all or a portion of the testosterone present in the sample to produce one or more testosterone ions that are detectable in a mass spectrometer. All or a portion of the testosterone present in the sample is ionized to produce one or more testosterone ions, which may be isolated and fragmented to produce precursor ions. A separately detectable internal testosterone standard can be provided in the sample. In a preferred embodiment, the reference is 2, 2, 4, 6, 6-d5 testosterone.Type: ApplicationFiled: October 11, 2005Publication date: February 23, 2006Inventors: Michael Caulfield, Darren Carns, Richard Reitz
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Patent number: 6977143Abstract: Provided are methods for determining the presence or amount of testosterone in a test sample, comprising ionizing all or a portion of the testosterone present in the sample to produce one or more testosterone ions that are detectable in a mass spectrometer. All or a portion of the testosterone present in the sample is ionized to produce one or more testosterone ions, which may be isolated and fragmented to produce precursor ions. A separately detectable internal testosterone standard can be provided in the sample. In a preferred embodiment, the reference is 2, 2, 4, 6, 6-d5 testosterone.Type: GrantFiled: December 2, 2003Date of Patent: December 20, 2005Assignee: Quest Diagnostics Investments IncorporatedInventors: Michael P. Caulfield, Darren A. Carns, Richard E. Reitz