Abstract: A system and computer-implemented method for container provenance tracking uses a build instruction file of a container image to output a new provenance document associated with the container image for distribution. For each file system layer of the container image specified in the build instruction file, an existing provenance document for the file system layer is inserted into the new provenance document. If there is no existing provenance document, information about each software component included in the file system layer is retrieved and inserted into the new provenance document.

Abstract: A forensic analysis method performed in respect of an endpoint device connected to a computer network. The forensic analysis method comprises collecting file system call data from the endpoint device. The file system call data corresponds to a plurality of system calls relating to file system operations arising from activity performed on the endpoint device. The forensic analysis method also comprises collecting network communication metadata from the endpoint device. The network communication metadata is based on a plurality of system calls relating to communication operations over the computer network arising from activity performed on the endpoint device.

Abstract: A system and computer-implemented method for container provenance tracking uses a build instruction file of a container image to output a new provenance document associated with the container image for distribution. For each file system layer of the container image specified in the build instruction file, an existing provenance document for the file system layer is inserted into the new provenance document. If there is no existing provenance document, information about each software component included in the file system layer is retrieved and inserted into the new provenance document.

Abstract: A forensic analysis method performed in respect of an endpoint device connected to a computer network. The forensic analysis method comprises collecting file system call data from the endpoint device. The file system call data corresponds to a plurality of system calls relating to file system operations arising from activity performed on the endpoint device. The forensic analysis method also comprises collecting network communication metadata from the endpoint device. The network communication metadata is based on a plurality of system calls relating to communication operations over the computer network arising from activity performed on the endpoint device.

Abstract: The present invention relates to soluble fragments of the Influenza virus RNA dependent RNA polymerase subunit PB2 and variants thereof, and crystallized complexes thereof comprising an RNA cap analog. This invention also relates to computational methods using the structural coordinates of said complex to screen for and design compounds that interact with the RNA cap binding pocket. In addition, this invention relates to methods identifying compounds that bind to PB2 polypeptide fragments comprising the RNA cap binding pocket, preferably inhibit the interaction with RNA caps or analogs thereof, by using said PB2 polypeptide fragments, preferably in a high-throughput setting. This invention also relates to compounds and pharmaceutical compositions comprising the identified compounds for the treatment of disease conditions due to viral infections caused by negative-sense single stranded RNA viruses.

Abstract: Communication traffic isolation and control systems and methods are disclosed. Communication traffic streams are received and either passed or filtered by respective controllable filtering modules. The operation of the filtering modules is controlled on a per-module and thus a per-stream basis, responsive to congestion of filtered communication traffic streams at a communication traffic processing element to which the filtering modules are connected. Per-stream filtering provides traffic control for each communication traffic stream, and maintains isolation between the streams. Statistics associated with communication traffic filtered out of each stream may be collected, and possibly aggregated.

Abstract: A plastic container includes an upper portion having a mouth defining an opening into the container. A shoulder region extends from the upper portion. A sidewall portion extends between the shoulder region and a base portion. The base portion closes off an end of the container. A vacuum panel region defined in part by at least two vacuum panels. Each of the vacuum panels are movable to accommodate vacuum forces generated within the container resulting from heating and cooling of its contents. The vacuum panel region occupies an area outboard of the sidewall portion.

Abstract: The present invention relates to methods of screening for expression of a soluble candidate protein within an expression library of candidate proteins. The method involves fusing each candidate protein in the library to a peptide substrate and identifying cells that express soluble candidate protein by detecting enzymatic modification of the peptide substrate.

Abstract: A system and method for providing APS (automatic protection switching) redundant pair control protocol signaling for multi-nodal APS (MN-APS) is provided. Periodic liveliness messages are exchanged between each node of a redundant pair. Each liveliness message contains an IHY (I heard you) message which indicates whether or not the sender of the liveliness message received within a duration of a hold time a previously transmitted liveliness message from the recipient. When more than one MN-APS group is configured between two redundant nodes, liveliness messages are bundled together to reduce processing loads.

Abstract: Systems and methods of monitoring a communication traffic transfer rate control mechanism are provided. The traffic transfer rate control mechanism may control a rate of transfer of communication traffic from a first communication traffic management device to a second communication traffic management device, for example. A communication traffic storage history, which is indicative of an effect of the transfer rate control mechanism, is compiled by determining amounts of communication traffic stored in at least one communication traffic queue of at least one of the communication traffic management devices, at each of a number of monitor times. An indication of the determined amounts of communication traffic is provided, and may be analyzed to determine whether the transfer rate control mechanism actually achieves a desired effect. The transfer rate control mechanism or control parameters thereof may then be adjusted if the desired effect is not currently being achieved.

Abstract: Communication traffic management systems and methods are disclosed. A threshold status of a communication traffic queue of a second communication traffic management device which is capable of receiving communication traffic from a first communication traffic management device is determined, by comparing a depth of the queue to a corresponding threshold for instance. A rate of transfer of communication traffic to the second device, and possibly to particular queues of the second device from corresponding queues of the first device, is controlled based on the threshold status. Transmission of communication traffic from the queues of the second device may thus be in accordance with one communication traffic management scheme, whereas the content of each queue of the second device is controlled according to another communication traffic management scheme used by the first device to transfer communication traffic from its queues, to thereby provide for complex combined communication traffic management.

Abstract: The present invention relates to methods of screening for expression of a soluble candidate protein within an expression library of candidate proteins. The method involves fusing each candidate protein in the library to a peptide substrate and identifying cells that express soluble candidate protein by detecting enzymatic modification of the peptide substrate.

Abstract: The Inventors herein describe methods for the production of a functional human, animal, plant or microbe protein arrays and methods to assay for interactions between the proteins on the array with molecules of interest, for example, using such arrays to determine the in vitro metabolite profile of any drug. Such protein arrays can be used, for example, to assay, in a parallel fashion, the protein products of DNA sequences encoding drug metabolising enzymes (DMEs) to obtain a toxicology profile. Also described herein is a novel DME expression and purification strategy using detergents and not requiring an ultra-centrifugation step.

Abstract: The present invention provides use of a protein conjugate comprising a “ble” protein, which has specific binding properties. The protein conjugates are capable of binding reversibly to an antibiotic from the bleomycin family, which property is exploited in a variety of immobilisation methods. In preferred aspects of the invention, the conjugates are used as markers for protein expression and/or folding, or for affinity tagging. The present invention also provides a probe comprising an array of an immobilised antibody from the bleomycin family, which acts as an analyte capture moiety. In another aspect, a purification media is provided, which comprises an antibiotic of the bleomycin family as an analyte capture moiety. Also provided is a method for generating soluble forms of an insoluble protein by expressing the protein as a “ble” fusion protein and selecting in the presence of an antibiotic from the bleomycin family.

Abstract: The use of a tag moiety comprising a biotinylation domain, such as biotin carboxyl carrier protein (BCCP), as a protein folding marker and protein solubility enhancer in the orientated surface capture of products of heterologously expressed genes is described. Methods for increasing the solubility of proteins and determining the folded state of a protein are also disclosed. The uses and methods of the invention can be carried out in a multiplexed manner on more than one protein in the formation of libraries. In addition the nucleic acid molecule encoding the biotinylation domain of the tag moiety can be used to increase the proportion of clones in a library that express the protein of interest.