Patents by Inventor Darwin Prockop

Darwin Prockop has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enhanced growth of adult stem cells with Dkk-1
    Patent number: 7485460
    Abstract: The present invention encompasses methods and compositions for enhancing the growth of adult marrow stromal cells.
    Type: Grant
    Filed: May 21, 2003
    Date of Patent: February 3, 2009
    Assignee: Tulane University Health Sciences Center
    Inventors: Darwin Prockop, Ichiro Sekiya, Carl Gregory, Jeffrey Spees, Jason Smith, Radhika Pochampally
  • Inhibitors of Dkk-1
    Publication number: 20080085281
    Abstract: The present invention encompasses methods and compositions for enhancing the growth of adult marrow stromal cells. The present invention also encompasses methods and compositions for regulating the effects of Dkk-1. Methods and compositions for treatment of osteolytic lesions in multiple myeloma and enhancing osteogenesis are also included.
    Type: Application
    Filed: July 25, 2007
    Publication date: April 10, 2008
    Applicant: The Administrators of the Tulane Educational Fund
    Inventors: Darwin Prockop, Carl Gregory, William Gunn
  • Directed in vitro differentiation of marrow stromal cells into neural cell progenitors
    Publication number: 20070036772
    Abstract: The invention relates to methods for inducing marrow stromal cells to differentiate into neural cells by way of increasing intracellular levels of cyclic AMP. The invention also encompasses methods of producing a neural cell by causing a marrow stromal cell to differentiate into a neural cell by increasing intracellular levels of cyclic AMP. Methods for treating a human patient in need of neural cells are also disclosed, as well as methods for treating a human patient having a disease, condition, or disorder of the central nervous system.
    Type: Application
    Filed: July 12, 2006
    Publication date: February 15, 2007
    Inventors: Darwin Prockop, Weiwen Deng
  • Early-stage multipotential stem cells in colonies of bone marrow stromal cells
    Publication number: 20060223106
    Abstract: Marrow stromal cells (MSCs) are adult stem cells from bone marrow that can differentiate into multiple non-hematopoietic cell lineages. Colonies of human MSCs were shown to contain both small, rapidly self-renewing stem cells (RS cells) and large, more mature cells (mMSCs). Samples enriched for RS cells had a greater potential for multipotential differentiation than samples enriched for mMSCs. Also, RS cells have a series of surface epitopes and expressed proteins that can be used to differentiate RS cells from mMSCs. The results suggest that it will be important to distinguish the two major sub-populations of MSCs in defining their biology and their potentials for cell and gene therapy.
    Type: Application
    Filed: June 2, 2006
    Publication date: October 5, 2006
    Inventors: Darwin Prockop, David Colter, Ichiro Sekiya
  • Inhibitors of Dkk-1
    Publication number: 20050084494
    Abstract: The present invention encompasses methods and compositions for enhancing the growth of adult marrow stromal cells. The present invention also encompasses methods and compositions for regulating the effects of Dkk-1. Methods and compositions for treatment of osteolytic lesions in multiple myeloma and enhancing osteogenesis are also included.
    Type: Application
    Filed: May 5, 2004
    Publication date: April 21, 2005
    Inventors: Darwin Prockop, Carl Gregory, William Gunn
  • In vitro differentiation of adult stem cells
    Publication number: 20040235165
    Abstract: The present invention includes a method for differentiating marrow stromal cells (MSCs) in vitro. The present invention also includes a method for improving the recovery rate of a mammal afflicted with a neuronal injury. The present invention also includes a method for enhancing the differentiation of marrow stromal cells to hypertrophic chondrocytes.
    Type: Application
    Filed: May 19, 2003
    Publication date: November 25, 2004
    Inventors: Darwin Prockop, Jeffrey L. Spees, Ichiro Sekiya
  • Enhanced growth of adult stem cells
    Publication number: 20040235166
    Abstract: The present invention encompasses methods and compositions for enhancing the growth of adult marrow stromal cells.
    Type: Application
    Filed: May 21, 2003
    Publication date: November 25, 2004
    Inventors: Darwin Prockop, Ichiro Sekiya, Carl Gregory, Jeffrey Spees, Jason Smith, Radhika Pochampally
  • Antisense oligonucleotides to inhibit expression of mutated and wild type genes for collagen
    Patent number: 5861502
    Abstract: The present invention is directed to oligonucleotides that inhibit mutant COL1A1 and/or wild type COL1A1 gene expression. The present invention is further directed to methods of inhibiting mutant and/or wild type collagen gene expression using the disclosed inhibitory oligonucleotides. The oligonucleotides and methods of the present invention are useful for the treatment of mammals having diseases related to inappropriate mutant or wild type COL1A1 gene expression.
    Type: Grant
    Filed: June 30, 1995
    Date of Patent: January 19, 1999
    Assignee: Thomas Jefferson University
    Inventors: Darwin Prockop, Alain Colige, Renato Baserga, Paul Nugent