Abstract: In one aspect, the disclosure relates to substituted N-(2-(2,6-dioxopiperidinyl-3-yl)-1,3-dioxoisoindolin-5-ypaiylsulfo namide analogs that useful as modulators of cereblon (CRBN) activity, methods of making same, pharmaceutical compositions comprising same, and methods of treating various clinical conditions and disorders using same, e.g., a disorder of uncontrolled cellular proliferation, such as a cancer, which may be associated with cereblon protein dysfunction and/or a GSPT1 dysfunction. In various further aspects, the disclosed compounds can selectively modulate the degradation of GSPT1 protein, i.e., the disclosed compounds can act as GSPT1 degraders. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: The invention relates to a bainite steel consisting of the following elements in weight %: C: 0.25-0.55 Si: 0.5-1.8 Mn: 0.8-3.8 Cr: 0.2-2.0 Ti: 0.0-0.1 Cu: 0.0-1.2 V: 0.0-0.5 Nb: 0.0-0.06 Al: 0.0-2.75 N: <0.004 P: <0.025 S: <0.025 and a method for manufacturing a bainite steel strip that comprises the step of cooling the coiled strip of such composition to ambient temperature, during which the bainite transformation takes place.

Abstract: The invention relates to a bainite steel consisting of the following elements in weight %: C: 0.25-0.55 Si: 0.5-1.8 Mn: 0.8-3.8 Cr: 0.2-2.0 Ti: 0.0-0.1 Cu: 0.0-1.2 V: 0.0-0.5 Nb: 0.0-0.06 Al: 0.0-2.75 N: <0.004 P: <0.025 S: <0.025 and a method for manufacturing a bainite steel strip that comprises the step of cooling the coiled strip of such composition to ambient temperature, during which the bainite transformation takes place.