Abstract: The present disclosure is directed to compositions and methods for formulating a pharmaceutical dosage form by forming a composition comprising acetyl-11-keto-?-boswellic acid, diindolylmethane, or curcumin with one or more pharmaceutically acceptable excipients for enhanced solubility to increase bioavailability and improve therapeutic efficacy. The composition can be processed by thermo-kinetic compounding along with conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.

Abstract: Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.

Abstract: Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.

Abstract: A method of detecting and diagnosing system faults, includes detecting the noisy status of a monitor during operations and incorporating a quantified monitor uncertainty level to support fault isolation reasoning. A sequential probability ratio test is used to statistically test the noisy status of a monitor and Shannon's entropy theory is used to quantify the uncertainty levels of the monitor to support the use of the monitor values in fault isolation.

Abstract: A method of detecting and diagnosing system faults, includes detecting the noisy status of a monitor during operations and incorporating a quantified monitor uncertainty level to support fault isolation reasoning. A sequential probability ratio test is used to statistically test the noisy status of a monitor and Shannon's entropy theory is used to quantify the uncertainty levels of the monitor to support the use of the monitor values in fault isolation.

Abstract: Provided are methods and systems distributing a data message to an unknown destination device across at least one spatial boundary and at least one administrative domain boundary from an originating device. The system includes at least one distributor module that exists within each administrative domain of a network through which the data message may originate, may terminate or may traverses in route from the originating device to the unknown destination device. Each administrative domain within each of a plurality of equipment platforms has at least one distributor module. The system also includes a domain bridge spanning the at least one administrative domain boundary within an equipment platform of the plurality through which the data message traverses in route to the unknown destination device. The system operates using a network discovery service whereby an advertisement is published for a specific type of data by the unknown destination device. The advertisement is promulgated throughout the network.

Abstract: A mounting bracket for a prefabricated column assembly comprising a column having an external wall and an internal wall defining a channel for receiving a mounting post, the mounting bracket configured to be received by the channel having a body defining a hole for receivingly engaging the mounting post and having a peripheral edge. The peripheral edge defining a slot for receiving an elongated support strip for providing a lateral support anchor for the column assembly.

Abstract: A health monitoring system includes a first monitoring unit configured to monitor health status indicators of a subject system; and a second monitoring unit configured to monitor the health status indicators of the subject system upon receiving a transfer signal.

Abstract: Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.

Abstract: A hot-melt extruded composition having finely divided drug-containing particles dispersed within a polymeric and/or lipophyllic carrier matrix is provided. The carrier softens or melts during hot-melt extrusion but it does not dissolve the drug-containing particles during extrusion. As a result, a majority or at least 90% wt. of the drug-containing particles in the extrudate are deaggregated during extrusion into essentially primary crystalline and/or amorphous particles. PEO is a suitable carrier material for drugs insoluble in the solid state in this carrier. Various functional excipients can be included in the carrier system to stabilize the particle size and physical state of the drug substance in either a crystalline and/or amorphous state. The carrier system is comprised of at least one thermal binder, and may also contain various functional excipients, such as: super-disintegrants, antioxidants, surfactants, wetting agents, stabilizing agents, retardants, or similar functional excipients.

Abstract: A mounting bracket for a prefabricated column assembly comprising a column having an external wall and an internal wall defining a channel for receiving a mounting post, the mounting bracket configured to be received by the channel having a body defining a hole for receivingly engaging the mounting post and having a peripheral edge. The peripheral edge defining a slot for receiving an elongated support strip for providing a lateral support anchor for the column assembly.

Abstract: Computerized resource accounting methods and systems, and in particular computerized utility resource management methods and systems, multi-user utility resource management methods and systems, and energy-consumption-based tracking methods and systems are described. In one implementation, a host computer includes a processor, an interface device and a database defined therein for maintaining information pertaining to one or more customers of one or more resources. Resource usage information is received into the host computer pertaining to consumption of one or more of the resources by one or more of the customers at one or more customer site. The resource usage information is processed to provide usage-based, computer-viewable data associated with a respective customer's consumption of one or more of the resources.

Abstract: Computerized billing and payment authorization methods and systems are described. In one aspect, a host system includes a database in which information associated with a billable entity from which payment is to be received is stored. Billing information is received from a billing entity and is associated with a bill for payment by the billable entity. The billable entity is provided with remote electronic access to the billing information in the host computer and can authorization payment thereof. In one implementation, the billing information is scrutinized in accordance with pre-determined tolerance parameters prior to the billable entity gaining access thereto. In another implementation, a plurality of billing entities provide billing information to the host system, with the billing information being subsequently checked and consolidated into a consolidated amount which can be remotely accessed by the billable entity.

Abstract: Computerized billing and payment authorization methods and systems are described. In one aspect, a host system includes a database in which information associated with a billable entity from which payment is to be received is stored. Billing information is received from a billing entity and is associated with a bill for payment by the billable entity. The billable entity is provided with remote electronic access to the billing information in the host computer and can authorization payment thereof. In one implementation, the billing information is scrutinized in accordance with pre-determined tolerance parameters prior to the billable entity gaining access thereto. In another implementation, a plurality of billing entities provide billing information to the host system, with the billing information being subsequently checked and consolidated into a consolidated amount which can be remotely accessed by the billable entity.

Abstract: Computerized resource accounting methods and systems, and in particular computerized utility resource management methods and systems, multi-user utility resource management methods and systems, and energy-consumption-based tracking methods and systems are described. In one implementation, a host computer includes a processor, an interface device and a database defined therein for maintaining information pertaining to one or more customers of one or more resources. Resource usage information is received into the host computer pertaining to consumption of one or more of the resources by one or more of the customers at one or more customer site. The resource usage information is processed to provide usage-based, computer-viewable data associated with a respective customer's consumption of one or more of the resources.