Abstract: An electro-absorption modulator (EAM) is configured to include an on-chip AC ground plane that is used to terminate the high frequency RF input signal within the chip itself. This on-chip ground termination of the modulation input signal improves the frequency response of the EAM, which is an important feature when the EAM needs to support data rates in excess of 50 Gbd. By virtue of using an on-chip ground for the very high frequency signal content, it is possible to use less expensive off-chip components to address the lower frequency range of the data signal (i.e., for frequencies less than about 1 GHz).

Abstract: An adaptive billboard frame mount system, and methods of use thereof, that is configured to mount to a plurality of fixedly positioned pre-existing poles. The billboard frame mount system includes a frame assembly and a plurality of mount assemblies configured to be coupled to the plurality of fixedly positioned pre-existing poles and the frame assembly such that a formed frame of the frame assembly can be positioned in a display plane that is oriented at a desired angle relative to vertical.

Abstract: The instant disclosure provides antibodies that specifically bind to LAG-3 (e.g., human LAG-3) and antagonize LAG-3 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Abstract: Purifying target biomolecules, such as nucleic acids or proteins, from a biological source is a time intensive process and is typically performed by a skilled technician or scientist owing to the highly technical nature of the work. Systems, devices, and methods disclosed herein enable the automated bioprocessing and purification of target biomolecules from a biological source. For example, an instrument and disposable cartridge are provided for automatedly isolating and purifying nucleic acids (such as plasmid DNA from a bacterial culture) or for isolating protein from any biological sample. Such an exemplary instrument and cartridge can work in concert to timely release, mix, and move the target biomolecule and various reagents and buffers through a target biomolecule purification process, resulting in a purified target biomolecule with less manual oversight than traditional approaches.

Abstract: Provided are antibodies that specifically bind to CTLA-4 and/or PD-1 and antagonize CTLA-4 and/or PD-1 function. Also provided are pharmaceutical compositions and kits comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies either alone or in combination.

Abstract: The present disclosure generally relates to auditory nerve stimulation to create the perception of sound in the brain of a subject such as an animal or human being. In one form, a system includes an implantable electrode array including a plurality of spaced apart micro-needles. The system also includes a first electrical lead electrically coupled to and extending from the implantable electrode array, and an auditory signal device configured to produce one or more electrical signals representative of communications received from an external processor. An interposer is configured to electrically couple the implantable electrode array and the auditory signal device in an arrangement where one or more electrical signals produced by the auditory signal device may be transmitted through the first electrical lead to the implantable electrode array. Various novel stimulation strategies can be employed, such as place modulated stimulation signals.

Abstract: An interactive system may be implemented in part by an audio device located within a user environment, which may accept speech commands from a user and may also interact with the user by means of generated speech. In order to improve performance of the interactive system, a user may use a separate device, such as a personal computer or mobile device, to access a graphical user interface that lists details of historical speech interactions. The graphical user interface may be configured to allow the user to provide feedback and/or corrections regarding the details of specific interactions.

Abstract: Charged nutritive proteins are provided. In some embodiments the nutritive proteins an aqueous solubility of at least 12.5 g/L at pH 7. In some embodiments the nutritive proteins an aqueous solubility of at least 50 g/L at pH 7. In some embodiments the nutritive proteins an aqueous solubility of at least 100 g/L at pH 7.

Abstract: Implementations of the present disclosure include actions of receiving image data of an image capturing a scene, receiving data describing one or more entities determined from the scene, the one or more entities being determined from the scene, determining one or more actions based on the one or more entities, each action being provided at least partly based on search results from searching the one or more entities, and providing instructions to display an action interface comprising one or more action elements, each action element being to induce execution of a respective action, the action interface being displayed in a viewfinder.

Abstract: A mounting device may include a top plate including a cone-shaped center portion, a flange coupled to the cone-shaped center portion, a number of apertures defined in the flange, and a number of fasteners engaged with the apertures to couple the top plate to a surface of a structure. The flange seals a bottom side of the top plate to the surface of the structure. The flange includes a seal coupled to the bottom of the flange. The cone-shaped center portion has a convex paraboloid shape. The flange includes at least one surface that is parallel to a surface of the structure, and a transition between the cone-shaped center portion and the flange forms an angle. The top plate has a diameter sufficient to displace a load greater than 50 pounds over the surface of the structure.

Abstract: Aspects of the present disclosure relate to systems and methods for sorting one or more files hosted by a collaborative application. In one aspect, one or more activity signals associated with one or more files hosted by the collaborative application may be received from a substrate. An activity-based sort order may be determined using at least a combination of the one or more activity signals. The activity-based sort order may be applied to sort the one or more files hosted by the collaborative application for display in a user interface to an activity object of the collaborative application.

Abstract: Electronic stethoscopes may have various accessories, modular components, and various configurations for powering the various components and accessories of the electronic stethoscope. In one embodiment, an electronic stethoscope apparatus includes a microphone configured to generate an electrical signal in response to received sound from a living subject; amplification circuitry; a speaker operably coupled to the amplification circuitry to output the electric signal after amplification; and a power supply configured to power the amplification circuitry. Circuitry for advanced signal processing may also be included, such as noise cancelling circuitry. The electronic stethoscope may also include removable electronic modules for wired or wireless headphones, battery packs, lights, and/or an electronic device for implementing the percussive method.

Abstract: A remotely deployed, inflatable device designed to reduce or eliminate falls in senior living and assisted care facilities. Upon detecting undesired movement, nurses may deploy one or more inflatable cylinders, thereby inflating the device under one or both sides of the mattress, creating a barrier that prevents the resident from exiting the bed until on-site assistance arrives. It is envisioned that initially the operation of the device will rely on the remote monitoring of residents by one or more operators via live camera feeds. In more advanced versions it is envisioned that software and artificial intelligence will be able to use one or more camera feeds and will be able to supplement or even replace the need for a person to monitor any camera feeds.

Abstract: Systems disclosed herein are directed to a display stand unit for a retail environment. The display stand unit includes a base having an interior and a display stand. The display stand includes a stem that connects to and extends upwardly from the base and a receiving surface that is suspended above and spaced away from the base by the stem. The receiving surface is configured to releasably hold an electronic device above and spaced away from the base. The display stand unit further includes a security cable that extends out from the base. The security cable is configured to attach to the electronic device to movably secure the electronic device to the base. The display stand unit further includes a retractor disposed within the interior of the base and connected to the security cable. The retractor automatically retracts the security cable.

Abstract: A joint spacer therapeutically maintains separation of bones of a joint. A carriage is slideably retained within the frame and has at least one ramped surface. An actuator screw is threadably engaged with the frame, and rotatably connected to the carriage, to cause the carriage to slideably move within the frame when the actuator screw is rotated. First and second endplates engage the bones of the joint, and each has at least one ramped surface that is mateable with the ramped surface of the carriage, whereby when the carriage is slideably moved by rotation of the actuator screw, the endplates ramped surface slides against the carriage ramped surface to cause the endplates to move along an axis transverse to the longitudinal axis of the frame, to increase the height of the spacer. Piercing elements are connected to the carriage to pierce bone of the joint when the carriage is moved.

Abstract: The present disclosure is directed to processing imagery using one or more machine learning (ML) models. In particular, data describing imagery comprising a plurality of different and distinct frames can be received; and based at least in part on one or more ML models and the data describing the imagery, and for each frame of the plurality of different and distinct frames, one or more scores can be determined for the frame. Each score of the score(s) can indicate a determined measure of suitability of the frame with respect to one or more of various different and distinct uses for which the ML model(s) are configured to determine suitability of imagery.

Abstract: A system and method of identifying objects is provided. In one aspect, the system and method includes a hand-held device with a display, camera and processor. As the camera captures images and displays them on the display, the processor compares the information retrieved in connection with one image with information retrieved in connection with subsequent images. The processor uses the result of such comparison to determine the object that is likely to be of greatest interest to the user. The display simultaneously displays the images the images as they are captured, the location of the object in an image, and information retrieved for the object.

Abstract: A guide for cutting a dowel pin of a rotor assembly is provided. The guide includes a catch basin, including a first catch basin portion and a second catch basin portion, and a shim. The first catch basin portion and the second catch basin portion form a cutting tool receiver. The shim extends from a first edge having a cross-section that is complementary to a surface of the rotor assembly. The first catch basin portion and the second catch basin portion form a receptacle that accommodates and retains portions of a dowel pin during and after removal of the dowel pin from the rotor assembly. The cutting tool receiver is defined by a receiver edge configured to guide a cutting surface of a cutting tool through a cross-section of a dowel pin.

Abstract: The referral system described herein can give users the ability to recommend a vendor (such as, e.g., a company or a service provider) to another user via electronic sharing of a dynamically generated code when one or more pre-established conditions have been met, such as when the vendor has submitted a qualifying offer to the referral system and the user is verified to have previously utilized the referral system to redeem a prior offer of the given vendor.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, that identify and issue search queries expected to be issued in the future. A set of search queries that have been issued by multiple user devices can be obtained. For each query instance, contextual data can be obtained. A first query and its contextual data can be input to a model that outputs the query's likelihood of being issued in the future. The model can be trained using contextual data for training queries and a corresponding labels for the training queries. The learning model outputs the first query's likelihood of being issued in future, and this query is stored as a repeatable query if the likelihood satisfying a repeatability threshold. Subsequently, a stored repeatable query is issued upon a selection of a user selectable interface component and the search engine provides search results for the query.