Abstract: A hydraulic conduit bender may be provided. The hydraulic conduit bender may comprise a mast and a main bending cylinder. The mast may be disposed in a working position. The main bending cylinder may be disposed in the mast. The main bending cylinder may be operative to accept, on a throw extending from the main bending cylinder when the mast is in the working position, different sizes of a plurality of bending shoes without having to adjust a position of the main bending cylinder within the mast.

Abstract: The present disclosure is directed to a composite implant for the sustained release of a therapeutic agent from a hydrogel matrix. The hydrogel matrix may be a cross-linked bioerodible polyethylene glycol (PEG) hydrogel with a therapeutic complex dispersed within the cross-linked bioerodible PEG hydrogel. The therapeutic complex may include a therapeutic agent in association with either a fatty acid or fatty alcohol and/or any other excipients, peptides, or nucleic acids. The composite implant is configured to be delivered to or implanted into an eye of a subject or patient. The composite implant may comprise a rod shape. The composite implant may be used treat ocular disease in a subject or patient. Ocular diseases may be selected from at least one of neovascular age related macular degeneration (AMD), diabetic macular edema, or macular edema following retinal vein occlusion.

Abstract: A method for manufacturing microneedle devices and systems and tools for implementing same. The method can include manufacturing a replica mold and forming a microneedle array via the replica mold. The replica mold can be manufactured by disposing replica mold material on a master mold and curing the replica mold material. To reduce manufacturing time, the replica mold material preferably is cured at a high temperature for a relatively short time and then cooled quickly before removal from the master mold. The microneedle array can be formed by disposing microneedle material on the replica mold under vacuum and drying the microneedle material in single or successive disposing and drying operations. One or more optional backing layers can be added to the microneedle array when forming the microneedle device. Advantageously, the disclosed methods, systems and tools can be used to manufacture skin-applied patches for delivering cosmetic and therapeutic agents.

Abstract: A method for manufacturing microneedle devices and systems and tools for implementing same. The method can include manufacturing a replica mold and forming a microneedle array via the replica mold. The replica mold can be manufactured by disposing replica mold material on a master mold and curing the replica mold material. To reduce manufacturing time, the replica mold material preferably is cured at a high temperature for a relatively short time and then cooled quickly before removal from the master mold. The microneedle array can be formed by disposing microneedle material on the replica mold under vacuum and drying the microneedle material in single or successive disposing and drying operations. One or more optional backing layers can be added to the microneedle array when forming the microneedle device. Advantageously, the disclosed methods, systems and tools can be used to manufacture skin-applied patches for delivering cosmetic and therapeutic agents.

Abstract: A method for manufacturing microneedle devices and systems and tools for implementing same. The method can include manufacturing a replica mold and forming a microneedle array via the replica mold. The replica mold can be manufactured by disposing replica mold material on a master mold and curing the replica mold material. To reduce manufacturing time, the replica mold material preferably is cured at a high temperature for a relatively short time and then cooled quickly before removal from the master mold. The microneedle array can be formed by disposing microneedle material on the replica mold under vacuum and drying the microneedle material in single or successive disposing and drying operations. One or more optional backing layers can be added to the microneedle array when forming the microneedle device. Advantageously, the disclosed methods, systems and tools can be used to manufacture skin-applied patches for delivering cosmetic and therapeutic agents.

Abstract: A microneedle device suitable for application to the skin and methods for using the same. The microneedles are made of one or more biocompatible polymers that optionally provide a cosmetic benefit when dissolved within the skin. Optionally, the microneedles also may be used to deliver other active ingredients to the skin. The device is characterized by a microneedle layer, an intermediate layer of a liquid-soluble polymer, and an outer, liquid-permeable layer that is in fluid communication with the intermediate layer. In use, the device is applied to the skin such that the microneedles penetrate the skin surface. A liquid (e.g., water) is applied to the outer layer, causing dissolution of the intermediate layer, thereby detaching the microneedles within the skin from the device body. The remainder of the device is then removed and discarded.

Abstract: A wheel assembly positioning device. The device includes a wheel assembly cradle that holds a wheel assembly. A lifting device is also included that raises or lowers the wheel assembly cradle to allow a technician to dismount or mount a wheel assembly to a vehicle.

Abstract: A wheel assembly positioning device. The device includes a wheel assembly cradle that holds a wheel assembly. A lifting device is also included that raises or lowers the wheel assembly cradle to allow a technician to dismount or mount a wheel assembly to a vehicle.

Abstract: A cart, primarily for holding tools and miscellaneous other items, comprising a base tray on casters for being wheeled about, uprights extending up from the base tray carrying side trays and a removable top tray, and pegboards at opposite sides, components thereof being sized in such manner that, in disassembly, they can be compactly packaged in the base tray.