Abstract: A ligature-resistant folded-sheet paper towel dispenser includes a rear housing with a rear mounting plane surface for securing the ligature-resistant paper towel dispenser to a wall. A front cover is rotatably coupled and lockable to the rear housing, and a hidden paper outlet formed by the front cover, the rear housing, or a combination of the front cover and the rear housing is fed by a paper path terminating in an outlet slot at the bottom of the towel dispenser to dispense paper towels from a stack of folded-sheet paper towels. The paper path is inclined so that an exit of the outlet slot is directed toward the rear face of the housing to prevent upward insertion of a ligature. The cover is rounded to prevent formation of a ligature by looping, and the front cover and rear housing form a blind seam to prevent insertion of a ligature.

Abstract: Methods of reducing hepatitis delta virus (HDV) viral loads in a patient are provided. In some embodiments, the method comprises treating the patient with lonafarnib-ritonavir co-therapy. In some embodiments, the method further comprises treating the patient with an interferon.

Abstract: Methods of reducing hepatitis delta virus (HDV) viral loads in a patient are provided. In some embodiments, the method comprises treating the patient with lonafarnib-ritonavir co-therapy. In some embodiments, the method further comprises treating the patient with an interferon.

Abstract: In one aspect, methods of treating non-alcoholic steatohepatitis (NASH) or preventing or delaying the progression of non-alcoholic fatty liver disease (NAFLD) to NASH are provided. In some embodiments, the method comprises administering a therapeutically effective amount of ubenimex.

Abstract: An introducer may include a layered tubular member having an inner liner including at least one folded portion extending along a distal region of the inner liner in a delivery configuration; a reinforcing member disposed over at least a portion of the inner liner, the reinforcing member including a plurality of longitudinal spines defining a plurality of openings disposed between adjacent longitudinal spines, wherein each folded portion is circumferentially overlapped by one of the plurality of openings; and an outer sheath disposed over the reinforcing member, wherein the outer sheath includes at least one perforation circumferentially overlapping each folded portion; and a tip member fixedly attached to a tapered distal region of the layered tubular member. The inner liner may extend to a distal end of the layered tubular member. At least a portion of each folded portion may terminate proximal of the distal end of the layered tubular member.

Abstract: A ligature-resistant bag hanger for supporting an intravenous (IV) bag prevents formation of ligatures over an IV pole and on the bag support hooks. Internal components of the ligature-resistant IV bag hanger are enclosed in a housing. The internal components of the ligature-resistant bag hanger include one or more bag support hooks that have an extension portion extending from an interior of the housing and that are rotatable around an axle located within the housing. In a reset position, the bag support hook(s) support(s) an intravenous bag in a saddle portion of the hook up to a threshold weight limit. In a triggered position, initiated by a downward force in excess of the threshold weight limit rotating the hook downward, the hook rotates so that an attempted ligature formed above the saddle portion of the hook is released by retraction of the saddle portion of the within the housing.

Abstract: A system and method includes a seed roll of a saw type gin stand which can easily be inspected in an efficient and safe manner within the normal course of operation. The monitoring of the seed roll is desirable for prediction of irregularities that could significantly hamper the production of a ginning facility. This monitoring can take place by manual inspection with the eye or touch of the operator. In addition, this feature will facilitate the opportunity to introduce a new automatic process by which the control system can monitor the seed roll in order to improve overall productivity of the gin stand.

Abstract: Methods of reducing hepatitis delta virus (HDV) viral loads in a patient are provided. In some embodiments, the method comprises treating the patient with lonafarnib-ritonavir co-therapy. In some embodiments, the method further comprises treating the patient with an interferon.

Abstract: Tipifarnib or a tipifarnib derivative is used to treat HDV infection as a monotherapy or in combination with an interferon and/or boosting agent such as a CYP3A4 inhibitor such as ritonavir and cobicistat.

Abstract: In one aspect, methods of treating non-alcoholic steatohepatitis (NASH) or preventing or delaying the progression of non-alcoholic fatty liver disease (NAFLD) to NASH are provided. In some embodiments, the method comprises administering a therapeutically effective amount of pirfenidone. In some embodiments, the method comprises administering therapeutically effective amounts of pirfenidone and ubenimex as part of a combination therapy.

Abstract: In some aspects, a resonator device includes a dielectric substrate, a ground plane on a first side of the substrate, and conductors on a second, opposite side of the substrate. The conductors include first and second resonators and two baluns. Each balun includes a feed, a first branch and a second branch. The feed is connected to the first and second branches, and the first and second branches are capacitively coupled to the respective first and second resonators. The first branch includes a delay line configured to produce a phase shift relative to the second branch. The resonator device includes a sample region configured to support a magnetic resonance sample between the first and second resonators.

Abstract: A system and method includes a seed roll of a saw type gin stand which can easily be inspected in an efficient and safe manner within the normal course of operation. The monitoring of the seed roll is desirable for prediction of irregularities that could significantly hamper the production of a ginning facility. This monitoring can take place by manual inspection with the eye or touch of the operator. In addition, this feature will facilitate the opportunity to introduce a new automatic process by which the control system can monitor the seed roll in order to improve overall productivity of the gin stand.

Abstract: A medical device configured to be flexible and maintain kink resistance while also reducing strain fractures. The medical device may include an elongate tubular shaft defining a lumen extending from a proximal portion to a distal portion. The elongate tubular shaft may comprise an outer jacket forming an outer surface of the elongate tubular shaft, a support member including at least one filament extending in a helical configuration along at least a portion of the a length of the elongate tubular shaft, and a strain relief layer comprising a material that has a modulus of elasticity less than a modulus of elasticity of the outer jacket, the strain relief layer positioned at least between adjacent windings of the support member. The strain relief layer and the support member may collectively form an inner surface of the elongate tubular shaft.

Abstract: A ligature-resistant grab bar provides ligature-proof self-support of persons at toilets, showers, baths or other locations where persons require self-support assistance. The ligature-resistant grab bar includes an elongate body that may be an extruded member, which has a flange disposed at a planar rear surface extending from the elongate body on a first side and a second side of the elongate body. The sides of the elongate body have curved side channels for drainage of water that extend from an inner edge of the flange toward a central axis of the elongate body to a gripping profile forming a front of the elongate body, which may be circular or elliptical in cross-section, of a front half of the gripping profile. The ligature-resistant grab bar also includes a bottom end cap and a top end cap attached to the ends of the elongate body.

Abstract: Methods of reducing hepatitis delta virus (HDV) viral loads in a patient are provided. In some embodiments, the method comprises treating the patient with lonafarnib-ritonavir co-therapy. In some embodiments, the method further comprises treating the patient with an interferon.

Abstract: Methods of reducing hepatitis delta virus (HDV) viral loads in a patient are provided. In some embodiments, the method comprises treating the patient with lonafarnib-ritonavir co-therapy. In some embodiments, the method further comprises treating the patient with an interferon.

Abstract: A ligature-resistant thermostat cover provides restriction of access to a thermostat and prevention of ligature formation around or atop the thermostat. The thermostat cover includes a wall plate for securing to a wall with a central aperture for accommodating a thermostat, a cover portion and a locking mechanism. The cover portion is curved both toward the top and toward the bottom of the cover from an apex line to provide a continuously curving front surface of the cover portion. The rear profile of the cover portion matches a mating surface of a front profile of the wall plate in width and height and the wall plate has an incline or curvature at the top face to provide a continuously sloping surface that prevents formation of a ligature point above the top face.

Abstract: A ligature-resistant paper towel dispenser includes a rear portion with a towel recess for receiving a roll of paper towels and a planar mounting area for securing the paper towel dispenser to a wall. A front portion of the dispenser locks to the rear portion, covers the roll and completes the shape of the paper towel dispenser exterior. The mounting area of the housing may extend backwards from the planar mounting area into an aperture formed through a surface of the wall so that the towel recess projects into the wall. The housing has an upward projecting exterior that is curved or inclined downward from an apex to prevent attachment of a ligature and extends above the towel recess by a distance greater than or equal to half of a maximum forward projection of the housing to provide sufficient curvature or inclination of the exterior of the top projection.