Abstract: A two-part bioactive agent delivery system, the system including a disposable part comprising an agent reservoir, a bolus chamber, the volume of the bolus chamber being less than the volume of the agent reservoir, an agent outlet, and a valve having a first position communicating the agent reservoir with the bolus chamber and a second position communicating the bolus chamber with the outlet; and a reusable part including a valve driver, a power source and control electronics, the control electronics being adapted to control the valve driver to actuate the valve to deliver bioactive agent from the agent reservoir to the agent outlet; the system further having a spring extending between the agent reservoir piston and a surface of the reusable part or of the disposable part to pressurize the agent reservoir when the spring is compressed and the agent reservoir contains a quantity of bioactive agent.

Abstract: Some embodiments relate to an electro-mechanical actuator that includes a screw, structurally segregated (split) housings, first and second nuts coupled to the screw, a sensor assembly, a plurality of motors, and a controller. The first nut is coupled to a first mounting point, and the second nut is coupled to a second mounting point. The sensor assembly may generate signals indicative of (e.g., relative) positions of left and right units of the actuator or positions of the first nut and the second nut on the screw. The controller controls the motors based on the signals generated by the sensor assembly. The motors may rotate each nut about a screw axis of the screw. This rotation results in one or both nuts moving along the screw. Movement between the first nut and the second nut along the screw adjusts a distance between the first mounting point and the second mounting point.

Abstract: A Universal Serial Bus (USB) cable includes a connector and a switch. The connector includes a housing configured for gripping by a user to manually insert/remove the connector to/from a port of an electronic device. The connector includes a power line configured to enable transfer of power to the electronic device and a data line configured to enable exchange of data with the electronic device. The switch is integrated into the outer surface of the housing and includes, for example, a toggle that is mechanically movable between a first position that activates a private mode and a second position that deactivates the private mode. The exchange of data with the electronic device is only enabled while the toggle is in the second position, and the transfer of power to the electronic device is enabled regardless of whether the toggle is in the first position or the second position.

Abstract: A humidification system can include a heater base, a chamber, and a breathing circuit. The heater base includes a heater plate positioned in a recessed region, and a heat conductive portion of the chamber is configured to contact the heater plate. The heater base includes a guard configured to control movement of the chamber into and out of the recessed region. The guard includes an anti-racking mechanism. The chamber includes an inlet port, an outlet port. A downward extension extends into the chamber from the inlet port, and a baffle is disposed at a lower end of the downward extension. A component of the breathing circuit can include a conduit hanging end cap for shipping and storage. The end cap can include a hanging component to allow the breathing circuit component to be hung from a medical stand. The system can detect when breathing circuits are connected in reverse.

Abstract: Four-wheel steering of a vehicle, e.g., in which leading wheels and trailing wheels are steered independently of each other, can provide improved maneuverability and stability. A first vehicle model may be used to determine trajectories for execution by a vehicle equipped with four-wheel steering. A second vehicle model may be used to control the vehicle relative to the determined trajectories. For instance, the second vehicle model can determine leading wheels steering angles for steering leading wheels of the vehicle and trailing wheels steering angles for steering trailing wheels of the vehicle, independently of the leading wheels.

Abstract: A doser assembly includes a hopper assembly configured to receive filler material, a vibration transmission assembly coupled to the hopper assembly, and a paddle in a hopper opening that extends through the hopper assembly. The vibration transmission assembly includes a shaft that is configured to rotate around a central rotation axis, an eccentric that is fixed to the shaft and has a center that is radially offset from the central rotation axis, a connecting rod that is pivotably connected to the center of the eccentric, and a bracket that is pivotably connected to the connecting rod. A first end of the paddle is pivotably coupled to the hopper assembly at a paddle pivot joint. The paddle is fixed to the bracket of the vibration transmission assembly separately from the hopper assembly. The vibration transmission assembly is configured to cause the paddle to reciprocatingly pivot around the paddle pivot joint.

Abstract: Compound of formula (I) or a pharmaceutically acceptable salt, or N-oxide thereof, that are inhibitors of SSAO activity: where V, W, X, Y, Z, R1, and R3 are as defined herein.

Abstract: Various computers will communicate messages back and forth over a communication network. These communications may exchange various information. In one aspect, an apparatus for communicating data over a communication network may comprise a computer processor, a receiver, and a memory. The computer processor may generate a request for transmission to a first server via the communication network. The request may include a data inquiry for data about an authorized user of a communication device. The computer processor may also generate a communication message for transmission to the authorized user with a prompt to provide user data via the communication device. The receiver may receive a response from the first server and user data from the communication device. The computer processor may further format the user data and generate a dynamic value based on the formatted response for display.

Abstract: This application describes systems and techniques for adjusting one or more setting(s) of a vehicle based on detected condition(s) to avoid damage due to contact of the tires with a body, chassis, or other components of the vehicle. In some instances, the vehicle may determine a ride height of the vehicle, determine a limited range of steering angles based at least in part on the ride height, and control operation of the steering system of the vehicle based at least in part on the limited range of steering angles. In some instances, the vehicle may determine a steering angle of the vehicle, determine a limited range of ride heights based at least in part on the steering angle, and control operation of the suspension system of the vehicle based at least in part on the limited range of ride heights.

Abstract: A watercraft comprises a vehicle payload bay; a sail connected to the payload bay for propelling the watercraft in a foiling mode; and three or more hydrofoils connected to the payload bay. The hydrofoils are configured to provide control of the roll, pitch, and yaw of the watercraft and to elevate the vehicle payload by above a water surface when the watercraft is in the foiling mode. The hydrofoils can also provide control of roll, pitch, yaw, and elevation of the watercraft during the transition from a prone mode to a foiling mode. A mechanical propulsive system can be used for propelling the watercraft at least during transition from the prone mode to the foiling mode. The watercraft may not include a hull such that during the transition from the prone mode to the foiling mode, pitch and roll control are not substantially provided through the actions of gravity and buoyancy.

Abstract: A method of data storage includes determining a latency distance from a primary node to each of two or more replica nodes, choosing a preferred replica node of the two or more replica nodes based on the determined latency distances, and write-caching data into the preferred replica node.

Abstract: The subject matter described herein includes methods, systems, and computer readable media for proactive network testing. One method for proactive network testing includes receiving, by a test controller and via a network tap, at least one metric associated with live network traffic; determining, by the test controller and using the at least one metric and a threshold value associated with the at least one metric, that a network test is to be performed; configuring, by the test controller, a first test agent to execute the network test; and executing, by the first test agent, the network test.

Abstract: The invention relates, in general, to synthetic chimeric poxviruses, compositions comprising such viruses, and the development and use of systems and methods for producing such synthetic chimeric poxviruses. The synthetic chimeric poxviruses are well suited for live virus vaccines and pharmaceutical formulations.

Abstract: Systems, methods, computer-readable media, and apparatuses for providing hazard detection and broadcast functions are provided. In some examples, sensor data may be captured by a mobile device, vehicle, or the like. The data may be used to detect a hazard, identify a type of hazard, and the like. One or more users or groups of users for notification of the hazard may be identified and one or more notifications may be transmitted to users within the group.

Abstract: Four-wheel steering of a vehicle, e.g., in which leading wheels and trailing wheels are steered independently of each other, can provide improved maneuverability and stability. A first vehicle model may be used to determine trajectories for execution by a vehicle equipped with four-wheel steering. A second vehicle model may be used to control the vehicle relative to the determined trajectories. For instance, the second vehicle model can determine leading wheels steering angles for steering leading wheels of the vehicle and trailing wheels steering angles for steering trailing wheels of the vehicle, independently of the leading wheels.

Abstract: A humidification system can include a heater base, a chamber, and a breathing circuit. The heater base includes a heater plate positioned in a recessed region, and a heat conductive portion of the chamber is configured to contact the heater plate. The heater base includes a guard configured to control movement of the chamber into and out of the recessed region. The guard includes an anti-racking mechanism. The chamber includes an inlet port, an outlet port. A downward extension extends into the chamber from the inlet port, and a baffle is disposed at a lower end of the downward extension. A component of the breathing circuit can include a conduit hanging end cap for shipping and storage. The end cap can include a hanging component to allow the breathing circuit component to be hung from a medical stand. The system can detect when breathing circuits are connected in reverse.

Abstract: Compound of formula (I) or a pharmaceutically acceptable salt, or N-oxide thereof, that are inhibitors of SSAO activity: where V, W, X, Y, Z, R1, and R3 are as defined herein.

Abstract: A method of adapting a first key-value store to a second key-value store may include determining a conversion strategy based on one or more characteristics of the first key-value store and one or more characteristics of the second key-value store, converting the second key-value store to a converted key-value store based on the conversion strategy, and mapping the first key-value store to the converted key-value store based on a mapping function. The converted key-value store may be accessed on-the-fly. A data storage system may include a key-value interface configured to provide access to a lower key-value store, and a key-value adapter coupled to the key-value interface and configured to adapt an upper key-value store to the lower key-value store, wherein the key-value adapter may be configured to adapt at least two different types of the upper key-value store to the lower key-value store.

Abstract: Various embodiments relate generally to data science and data analysis, computer software and systems, and control systems to provide a platform to implement automated responses to data representing electronic messages, among other things, and, more specifically, to a computing and data platform that implements logic to facilitate implementation of an automated predictive response computing system being configured to implement, for example, an automated predictive response engine configured to access internal (e.g., in-conversation) data and external (e.g., extra-conversation) data to predictively generate automated responses, such as assisting an agent or an agent computing device, among other things.