Abstract: Control system configured for sample tracking in an electron microscope environment registers a movement associated with a region of interest located within an active area of a sample under observation with an electron microscope. The registered movement includes at least one directional constituent. The region of interest is positioned within a field of view of the electron microscope. The control system directs an adjustment of the electron microscope control component to one or more of dynamically center and dynamically focus the view through the electron microscope of the region of interest. The adjustment comprises one or more of a magnitude element and a direction element.

Abstract: This disclosure relates to mRNA therapy for the treatment of ornithine transcarbamylase deficiency (OTCD). mRNAs for use in the invention, when administered in vivo, encode human ornithine transcarbamylase (OTC). mRNA therapies of the disclosure increase and/or restore deficient levels of OTC expression and/or activity in subjects. mRNA therapies of the disclosure further decrease levels of toxic ammonia associated with deficient OTC activity in subjects.

Abstract: Control system configured for sample tracking in an electron microscope environment registers a movement associated with a region of interest located within an active area of a sample under observation with an electron microscope. The registered movement includes at least one directional constituent. The region of interest is positioned within a field of view of the electron microscope. The control system directs an adjustment of the electron microscope control component to one or more of dynamically center and dynamically focus the view through the electron microscope of the region of interest. The adjustment comprises one or more of a magnitude element and a direction element.

Abstract: Filtering device for filtering cerebrospinal fluid are disclosed. An example filtering device may include a filter housing having an inlet for receiving cerebrospinal fluid from a patient and an outlet for returning filtered cerebrospinal fluid to the patient. The filter housing may include a plurality of layers coupled together and defining a fluid pathway therein between the inlet and the outlet. A filtering section may be defined within the filter housing along the fluid pathway. The filtering section may include a widened region of the fluid pathway that is configured to slow the passage of fluid therethrough.

Abstract: A floating barrier system has a plurality of connected floating barrier units. Capture net segments are positioned on the floating barrier units by support post members, forming a barrier to vessel passage. Lanyards attach the ends of the capture net segments to the floating barrier units. Upon a vessel striking the capture net segments with sufficient force, the capture nets detach from the support post members and/or pull the support post members over, and the forces from the vessel are transferred via the lanyards to the floating barrier unit. The vessel is prevented from fully passing over the floating barrier unit, thus itself forming a barrier to passage by other vessels.

Abstract: An electrochemical cell that oxidizes a solution provides a continuous and stable supply of an oxidizing ion solution to a fixture or vessel used for the purposes of decontaminating metal and metal alloys. The electrochemical cell includes an anode compartment that oxidizes the solution in nitric acid or methane sulfonic acid at a rate equal to or greater than a rate of reduction, or generates the oxidizing ions prior to use in a batch. The electrochemical cell is part of a larger system that facilitates online measurement system which measures the oxidizing ion solution and the dissolved PuO2, UO2, AmO2, other radionuclides, or other contaminates in real-time. Solution decontamination system removes the dissolved PuO2/UO2/AmO2, other radionuclides, or other contaminates from the oxidizing ion solution, real time acoustic monitoring of the thickness of the surface being contaminated, and automation of a delivery system facilitates flow between surface and electrochemical cell.

Abstract: Devices, systems and methods for treating diseases and disorders effecting the cardiovascular system of the human body are disclosed. An exemplary device in accordance with this disclosure comprises a shaft, tip member fixed to the shaft, and a probe extending beyond a distal surface of the tip member. In some useful embodiments, the tip member is relatively atraumatic and the probe is shaped so as to be more likely to produce trauma than the tip member.

Abstract: Aspects of the present disclosure are directed to apparatuses for generating a magnetic field for tracking of a target object. Such an apparatus may include a localized magnetic field transmitter that generates a magnetic field and exhibits minimal X-ray absorption when used in proximity to a fluoroscopic imaging system, for example.

Abstract: A disposable staining system is provided including an insertable module configured to receive a biological sample therein, the insertable module including a well in which the biological sample is positioned; and a staining cartridge configured to receive the insertable module including the biological sample therein, the insertable module being positioned in the staining cartridge. The insertable module has first and second inclined planes on opposing sides of an upper surface of the insertable module. A sled configured to receive the insertable module has corresponding first and second inclined planes on a bottom surface thereof. The first and second inclined planes of the insertable module and the first and second inclined planes of the sled are configured to transform horizontal movement of the insertable module into the staining cartridge into a vertical movement of the sled such that the sled is pushed upward.

Abstract: Methods and apparatuses for detecting full waste canister and/or fluid flow path blockage conditions are disclosed. Also disclosed are methods and apparatuses for controlling a pump. In some embodiments, flow of fluid can be restricted in a portion of the fluid flow path. A controller can be configured to compare a difference in pressure values upstream and downstream of a fluid flow restrictor to a pressure difference threshold, and determine based on the comparison whether to activate an alarm indicating the full waste canister condition or the fluid flow path blockage condition. The controller can be additionally or alternatively configured to determine a fluid flow using a flow meter, open a selectable valve in response to a comparison of the fluid flow with a fluid flow threshold, determine fluid flow after opening the valve, and determine based on the fluid flow after opening the valve whether to activate the alarm.

Abstract: A method for combining multiple interactions into a single record entry is disclosed. A data package can be created that represents a set of interactions, and each entity associated with an interaction can review the data package. Each entity can indicate agreement with the interactions by digitally signing the data package. Once signed by each involved entity, the data package can be stored in a record such as a blockchain.

Abstract: A data migration and integration system is disclosed. In various embodiments, the system includes a memory configured to store a mapping from a source schema to a target schema; and a processor coupled to the memory and configured to migrate to a target schema an instance of source data organized according to the source schema, including by using a chase engine to perform an ordered sequence of steps comprising adding a bounded layer of new elements to a current canonical chase state associated with migrating the source data to the target schema; adding coincidences associated with one or more of the target schema data integrity constraints and a mapping from the source schema to the target schema; and merging equal elements based on the coincidences; and repeat the preceding ordered sequence of steps iteratively until an end condition is met.

Abstract: A registration fixture is configured for use with a medical imaging system. The registration fixture comprises a rigid internal structure comprising a plurality of fiducial markers arranged in a predefined pattern. The registration fixture further comprises a housing configured to surround the rigid internal structure. The registration fixture is configured to be mounted on a patient table.

Abstract: Provided are binding molecules, such as TCRs or antigen binding fragments thereof and antibodies and antigen-binding fragments thereof, such as those that recognize or bind human papilloma virus (HPV) 16, including HPV 16 E6 and HPV 16 E7. Also provided are engineered cells containing such binding molecules, compositions containing the binding molecules or engineered cells, and methods of treatment, such as administration of the binding molecules, engineered cells, or compositions.

Abstract: Systems, computer program products, and methods are described herein for virtualization of non-fungible tokens. The present invention is configured to receive, via a first user input device, a resource transfer request using a virtual token from a first user, wherein the virtual token is electronically linked to an NFT of a resource transfer instrument; retrieve the NFT associated with the resource transfer instrument in response to receiving the resource transfer request; retrieve an NFT credential descriptor for the resource transfer request from a first metadata layer of the NFT associated with the resource transfer instrument; receive an authentication credential from the first user; determine whether the authentication credential matches an NFT credential descriptor that is electronically linked to the NFT associated with the resource transfer instrument; and authorize the resource transfer request based on at least determining that the authentication credential matches an NFT credential descriptor.

Abstract: Systems and techniques are described for robust radar-based gesture-recognition. A radar system detects radar-based gestures on behalf of application subscribers. A state machine transitions between multiple states based on inertial sensor data. A no-gating state enables the radar system to output radar-based gestures to application subscribers. The state machine also includes a soft-gating state that prevents the radar system from outputting the radar-based gestures to the application subscribers. A hard-gating state prevents the radar system from detecting radar-based gestures altogether. The techniques and systems enable the radar system to determine when not to perform gesture-recognition, enabling user equipment to automatically reconfigure the radar system to meet user demand. By so doing, the techniques conserve power, improve accuracy, or reduce latency relative to many common techniques and systems for radar-based gesture-recognition.

Abstract: Core-shell particles, composite anode material, anodes made therefrom, lithium ion cells and methods are provided, which enable production of fast charging lithium ion batteries. The composite anode material has core-shell particles which are configured to receive and release lithium ions at their cores and to have shells that are configured to allow for core expansion upon lithiation. The cores of the core-shell particles are connected to the respective shells by conductive material such as carbon fibers, which may form a network throughout the anode material and possibly interconnect cores of many core-shell particles to enhance the electrical conductivity of the anode. Ionic conductive material and possibly mechanical elements may be incorporated in the core-shell particles to enhance ionic conductivity and mechanical robustness toward expansion and contraction of the cores during lithiation and de-lithiation.

Abstract: The invention relates to a silane, to a rubber mixture containing the silane and to a vehicle tire comprising the rubber mixture in at least one component.

Abstract: The present disclosure relates to a cartridge for an aerosol delivery device such as a smoking article. The cartridge may include a base, a reservoir substrate, and an atomizer. The reservoir substrate may define a cavity therethrough. The atomizer may comprise a liquid transport element and a heating element extending at least partially about the liquid transport element. The atomizer may extend through the cavity through the reservoir substrate such that the heating element is positioned proximate an end of the reservoir substrate. Ends of the liquid transport element may extend to an opposing end of the reservoir substrate. A related method for assembling a cartridge for a smoking article is also provided.

Abstract: A steerable delivery system is provided for delivering a replacement heart valve to a native heart valve location. The steerable delivery system includes an outer sheath assembly having a capsule along a distal end portion for retaining the replacement heart valve in a compressed configuration. The capsule is constructed to provide both compression resistance and flexibility. The capsule may be formed with an outer polymer layer, a metal middle layer located on a radially inner surface of the outer polymer layer, and an inner liner located on a radially inner surface of the metal middle layer. A fluoroelastomer layer is provided for bonding the inner liner to the metal middle layer. The metal middle layer is preferably a metal hypotube.