Abstract: The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

Abstract: The disclosed computer-implemented method for facilitating atomic delivery of bundled data sets to applications within distributed systems may include (1) receiving, at a queue of an application, a data set from at least one other application, (2) determining that the data set is incorporated in a bundle whose contents have yet to completely arrive at the queue, (3) gating the data set at the queue until the bundle's contents have completely arrived at the queue, (4) receiving, at the queue, another data set incorporated in the bundle, (5) determining that the bundle's contents have completely arrived at the queue based at least in part on receiving the other data set, and then (6) notifying the application that the bundle is ready for atomic delivery such that the application is able to consume the bundle's contents on an as-needed basis. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: Provided herein are systems, methods and computer readable media for scheduling services and other types of appointments in conjunction with purchasing and/or redeeming deal offers. Merchants may customize a scheduling system to provide scheduling capabilities and deal redemption capabilities to consumers interested in scheduling appointments. A consumer may use the scheduling system to select dates and times, merchant locations, and/or staff members, among other things, when scheduling appointments, and provide deal and/or other payment related information to the merchant. Merchants may use the scheduling system and consumer date received therefrom to track resources across numerous locations, keep apprised of their staffs' availability, receive/generate analytics data related to the affect deals have on their business, and gain a better understanding of their customers. The scheduling system may be integrated into the merchant's website and/or linked to deals offered by a third party promotional system.

Abstract: A system and device for providing power to and monitoring the energy usage of a device connected thereto includes a unit having one or more circuit boards having components for detecting the energy usage of the connected device and an interface for electrically connecting to the device. The unit communicates with a coordinator regarding the connected device or the state of the unit itself. Depending on the communication received from the unit, the coordinator relays the received data to a server and awaits instruction, or immediately commands the unit to take a certain action. If the server receives data from the coordinator, it sends such data to a remote server, saves it, generate reports based thereon, and/or alerts a user regarding same. The user can choose to send a command to the unit or device through the system, for example, to shut down, turn on, or to adjust the power being supplied to the device.

Abstract: The present invention relates to DEP2, as well as other proteins, and their uses in connection with the treatment of major depression or related disorders.

Abstract: The present invention relates to DEP2, as well as other proteins, and their uses in connection with the treatment of major depression or related disorders.

Abstract: There is provided, in accordance with an embodiment of the present invention, an platform, system, device, protocol and method are provided to enable video enhanced Push To Talk (PTT) communications. According to some embodiments, a method is provided for enabling asynchronous two-way video communications, comprising: when a video message sender records a message, recording a micro video file; encoding the video file as a binary-to-text string; storing the string in a Real Time Data (RTD) storage on the sender device; synchronizing the local RTD data change with a RTD server; synchronizing the sender binary-to-text string with receiver RTD storage; decoding said video file from the binary-to-text string; and playing the micro video file on the sender device.

Abstract: The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

Abstract: Provided herein are systems, methods and computer readable media for scheduling services and other types of appointments in conjunction with purchasing and/or redeeming deal offers. Merchants may customize a scheduling system to provide scheduling capabilities and deal redemption capabilities to consumers interested in scheduling appointments. A consumer may use the scheduling system to select dates and times, merchant locations, and/or staff members, among other things, when scheduling appointments, and provide deal and/or other payment related information to the merchant. Merchants may use the scheduling system and consumer date received therefrom to track resources across numerous locations, keep apprised of their staffs' availability, receive/generate analytics data related to the affect deals have on their business, and gain a better understanding of their customers. The scheduling system may be integrated into the merchant's website and/or linked to deals offered by a third party promotional system.

Abstract: A system and device for providing power to and monitoring the energy usage of a device connected thereto includes a unit having one or more circuit boards having components for detecting the energy usage of the connected device and an interface for electrically connecting to the device. The unit communicates with a coordinator regarding the connected device or the state of the unit itself. Depending on the communication received from the unit, the coordinator relays the received data to a server and awaits instruction, or immediately commands the unit to take a certain action. If the server receives data from the coordinator, it sends such data to a remote server, saves it, generate reports based thereon, and/or alerts a user regarding same. The user can choose to send a command to the unit or device through the system, for example, to shut down, turn on, or to adjust the power being supplied to the device.

Abstract: Provided herein is a method for detecting an HPA axis function marker in a biological sample. The method may be used to determine whether a patient is a suitable candidate for treatment with a V1B antagonist. The HPA marker may be a genomic marker, non-genomic marker, or a combination thereof. Depending on the type of HPA marker, the method of detection can be an immunoassay or genotyping, for example.

Abstract: A method for analyzing characteristics of a geological formation includes obtaining at a processor data representative of at least one of stratigraphic, structural, or physical characteristics of the geological formation, applying at the processor a wavelet transform to at least a portion of the obtained data or data interpreted or derived from the obtained data to derive one or more wavelet transform coefficients representative of the obtained data, segmenting at the processor at least one or more of the obtained data or data interpreted or derived from the obtained data into segments, determining at the processor a measure of variability of the obtained data or the data interpreted or derived from the obtained data over each segment at one or more scales of the wavelet transform.

Abstract: The present disclosure relates generally to systems and methods for the photo-inactivation of microorganisms. More specifically, the present invention is directed towards the photo-inactivation of microorganisms, such as viruses, using at least one furanocoumarin and broad spectrum pulsed light. For example, an aspect of the present invention includes a method for inactivating a herpesvirus, such as herpes B virus or herpes virus papio 2 using a psoralen and broad spectrum pulsed light.

Abstract: Nanotube-based structure and method of forming the same are disclosed. A structure having two tips is provided for defining a location for forming a nanotube connection. The nanotube connection, which can be coated with an electrically conductive polymer for enhanced conductivity, can be used in forming nanotube-based devices for various applications.

Abstract: A protocol for detecting faults in a bidirectional path between two forwarding engines, where parts of the bidirectional path checked may include interfaces, one or more data links, and to the extent possible the forwarding engines themselves, with potentially very low latency. The protocol may operate independently of media, data protocols, and routing protocols.

Abstract: A composition for treating insulin-dependent diabetes, reducing body fat, improving insulin sensitivity, reducing hyperglycemia, and reducing hypercholesterolemia with at least one chromium complex and a conjugated fatty acid or conjugated fatty alcohol is disclosed. A method of treating a subject suffering from insulin-dependent diabetes by administering a composition that includes at least one chromium complex and a conjugated fatty acid or conjugated fatty alcohol is similarly provided. The administration of a composition containing an effective dose of at least one chromium complex and a conjugated fatty acid or conjugated fatty alcohol for the treatment of obesity is likewise provided.

Abstract: A composition for treating insulin-dependent diabetes, reducing body fat, improving insulin sensitivity, reducing hyperglycemia, and reducing hypercholesterolemia with at least one chromium complex and a conjugated fatty acid or conjugated fatty alcohol is disclosed. A method of treating a subject suffering from insulin-dependent diabetes by administering a composition that includes at least one chromium complex and a conjugated fatty acid or conjugated fatty alcohol is similarly provided. The administration of a composition containing an effective dose of at least one chromium complex and a conjugated fatty acid or conjugated fatty alcohol for the treatment of obesity is likewise provided.