Patents by Inventor David A. Markovitz
David A. Markovitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200181620Abstract: The present invention provides methods of treatment using inhibitors of DEK protein and DEK activity. Such methods include, but are not limited to, methods of preventing, treating, and/or ameliorating inflammatory diseases, infections, autoimmune diseases, malignant diseases, and other diseases or conditions in which DEK has been implicated. Such inhibitors of DEK protein include, but are not limited to, pharmaceutical compositions including single stranded DNA or RNA aptamers capable of binding to DEK. In some embodiments, such aptamers are useful for diagnosing DEK related diseases or conditions. Related kits and compositions are further provided.Type: ApplicationFiled: February 11, 2020Publication date: June 11, 2020Inventors: David Markovitz, Nirit Mor-Vaknin, Maureen Legendre, David Engelke, Kristine Benford, Dave Pai
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Publication number: 20190071675Abstract: The present invention provides methods of treatment using inhibitors of DEK protein and DEK activity. Such methods include, but are not limited to, methods of preventing, treating, and/or ameliorating inflammatory diseases, infections, autoimmune diseases, malignant diseases, and other diseases or conditions in which DEK has been implicated. Such inhibitors of DEK protein include, but are not limited to, pharmaceutical compositions including single stranded DNA or RNA aptamers capable of binding to DEK. In some embodiments, such aptamers are useful for diagnosing DEK related diseases or conditions. Related kits and compositions are further provided.Type: ApplicationFiled: November 15, 2018Publication date: March 7, 2019Inventors: David Markovitz, Nirit Mor-Vaknin, Maureen Legendre, David Engelke, Kristine Benford, Dave Pai
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Patent number: 10138486Abstract: The present invention provides methods of treatment using inhibitors of DEK protein and DEK activity. Such methods include, but are not limited to, methods of preventing, treating, and/or ameliorating inflammatory diseases, infections, autoimmune diseases, malignant diseases, and other diseases or conditions in which DEK has been implicated. Such inhibitors of DEK protein include, but are not limited to, pharmaceutical compositions including single stranded DNA or RNA aptamers capable of binding to DEK. In some embodiments, such aptamers are useful for diagnosing DEK related diseases or conditions. Related kits and compositions are further provided.Type: GrantFiled: March 11, 2016Date of Patent: November 27, 2018Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: David Markovitz, Nirit Mor-Vaknin, Maureen Legendre, David Engelke, Kristine Benford, Dave Pai
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Publication number: 20180187196Abstract: The present invention provides methods of treatment using inhibitors of DEK protein and DEK activity. Such methods include, but are not limited to, methods of preventing, treating, and/or ameliorating inflammatory diseases, infections, autoimmune diseases, malignant diseases, and other diseases or conditions in which DEK has been implicated. Such inhibitors of DEK protein include, but are not limited to, pharmaceutical compositions including single stranded DNA or RNA aptamers capable of binding to DEK. In some embodiments, such aptamers are useful for diagnosing DEK related diseases or conditions. Related kits and compositions are further provided.Type: ApplicationFiled: March 11, 2016Publication date: July 5, 2018Inventors: David MARKOVITZ, Nirit MOR-VAKNIN, Maureen LEGENDRE, David ENGELKE, Kristine ANGEVINE, David PAI
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Patent number: 9481717Abstract: The present invention relates to chemical compounds, methods for their discovery, and their therapeutic and research use. In particular, the present invention provides antiviral and antimicrobial lectin compounds and methods of their use.Type: GrantFiled: October 2, 2014Date of Patent: November 1, 2016Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: David Markovitz, Michael Swanson, Irwin Goldstein, Harry Winter
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Publication number: 20150246067Abstract: The present invention provides compositions and methods to treat lymphoma and cancer. In particular, the present invention provides treatment of lymphoma and cancer using anti-HERV-K(HML-2) therapies. The present invention further provides compositions and methods for characterizing patient samples to, for example, select or identify therapeutic options or assess the impact of therapies.Type: ApplicationFiled: March 6, 2015Publication date: September 3, 2015Inventors: Mark H. Kaplan, Rafael Contreras-Galindo, David Markovitz
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Publication number: 20150080293Abstract: The present invention relates to chemical compounds, methods for their discovery, and their therapeutic and research use. In particular, the present invention provides antiviral and antimicrobial lectin compounds and methods of their use.Type: ApplicationFiled: October 2, 2014Publication date: March 19, 2015Inventors: David Markovitz, Michael Swanson, Irwin Goldstein, Harry Winter
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Patent number: 8865867Abstract: The present invention relates to chemical compounds, methods for their discovery, and their therapeutic and research use. In particular, the present invention provides antiviral and antimicrobial lectin compounds (BanLec) isolated from bananas. These compounds have low mitogenicity and pro-inflammatory activity while maintaining anti-HIV-1 activity.Type: GrantFiled: April 11, 2011Date of Patent: October 21, 2014Assignee: The Regents of the University of MichiganInventors: David Markovitz, Michael Swanson, Irwin Goldstein, Harry Winter
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Publication number: 20130096051Abstract: The present invention relates to chemical compounds, methods for their discovery, and their therapeutic and re-search use. In particular, the present invention provides antiviral and antimicrobial lectin compounds (BanLec) isolated from bananas. These compounds have low mitogenicity and pro-inflammatory activity whilst maintaining anti-HIV-1 activity.Type: ApplicationFiled: April 11, 2011Publication date: April 18, 2013Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: David Markovitz, Michael Swanson, Irwin Goldstein, Harry Winter
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Publication number: 20120135950Abstract: Compositions and methods to treat lymphoma and cancer are disclosed. In particular, the method teaches treatment of lymphoma and cancer using anti-HERV-K(HML-2) therapies. Further taught are compositions and methods for characterizing patient samples to, for example, select or identify therapeutic options or assess the impact of therapies.Type: ApplicationFiled: May 21, 2010Publication date: May 31, 2012Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Mark H. Kaplan, Rafael Contreras-Galindo, David Markovitz
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Publication number: 20090004197Abstract: The present invention relates to DEK protein compositions (e.g., antibodies, small molecule inhibitors, siRNAs) and methods of using the same. In particular, the present invention provides compositions and methods for treating autoimmune disease (e.g., juvenile rheumatoid arthritis, lupus, etc.) and for inhibiting inflammation (e.g., associated with autoimmune disease) and cellular chemotaxis (e.g., of neutrophils, NK cells and T cells). The present invention further provides a diagnostic marker (e.g., DEK antigen) for autoimmune disease.Type: ApplicationFiled: October 16, 2006Publication date: January 1, 2009Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: David A. Markovitz, Nirit Mor-Vaknin, Michael Khodadoust, Barbara S. Adams
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Publication number: 20080261216Abstract: The present invention relates to compositions and methods for cancer diagnosis and therapy, including but not limited to, cancer markers. In particular, the present invention relates to HERV-K(HML-2) target titers as diagnostic markers, and HERV-K(HML-2) therapeutic targets for HIV-related cancers, and other cancers.Type: ApplicationFiled: September 10, 2007Publication date: October 23, 2008Applicant: The Regents of the University of MichiganInventors: David Markovitz, Rafael Contreras-Galindo, Mark H. Kaplan, Michael H. Dosik
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Publication number: 20070202112Abstract: The present invention relates to compositions and methods for detecting cancer (e.g., prostate cancer) and for inhibiting metastasis (e.g., associated with prostate cancer). In particular, the present invention provides methods of detecting vimentin expression and secretion and for characterizing cancer (e.g., prostate cancer). In addition, the present invention provides methods for inhibiting metastasis (e.g., of prostate cancer) via altering (e.g., inhibiting) vimentin expression and/or activity.Type: ApplicationFiled: November 20, 2006Publication date: August 30, 2007Applicant: Regents of the University of MichiganInventors: David Markovitz, Nirit Mor-Vaknin, Evan Keller, Christopher Hall, Susan Hiniker