Abstract: The present invention relates to a sustained release composition for the targeted delivery of biologically active agents to specific tissues and cells. The composition comprises microparticles containing a biocompatible polymer, a water-soluble polymer and a biologically active agent. In one embodiment, the biologically active agent is an antigen or an immunomodulator. In another embodiment, the biologically is a labile agent. The microparticles have a number median diameter of greater than 20 microns upon administration. The water-soluble polymer is present in the sustained released composition in at least about 20% of the dry weight of the microparticle. the sustained release composition provides for the dissolution of the water-soluble polymer of the composition upon hydration, at a much greater rate than the degradation of the biocompatible polymer.

Abstract: Microparticles that include a bisphosphonate and a polymer are produced by a method that includes forming a water-in-oil emulsion by mixing an aqueous solution of the bisphosphonate with a combination of a biocompatible polymer and a polymer solvent. At least one aqueous liquid can be mixed with the water-in-oil emulsion to form a water-in-oil-in-water emulsion and to extract the polymer solvent from the polymer, thereby forming the microparticles. Methods of treating a patient in need of therapy include administering the microparticles described to the patient. In one embodiment, the microparticles are formulated for the sustained release of the bisphosphonate.

Abstract: An apparatus and process for the manufacture of silk-screens is provided for use in the printing of halftones, e.g. in a four color printing process. The angle at which the mesh of a silk-screen should be relative to the screen frame to eliminate or at least minimize or localize moire' is predetermined for each of the color film separations. This angle is then carried to stretching apparatus for the woven fabric from which the silk-screens are to be made. The stretching appararatus has a table that is provided with a plurality of rotatable members. A screen frame is placed on each of the rotatable members and the rotable member is rotated to the angle determined by the pre-registration apparatus. The fabric is stretched to the desired tension and the screen frames having been provided at the desired angles are adhered to the stretched fabric, resulting in the mesh in each silk-screen being at the correct angle with respect to the screen frame.

Abstract: Silk-screens of annular-shape are provided for the silk-screen printing of halftones on compact discs. The silk-screens are rotatably provided in a carrier so that the angle at which moire can be eliminated or at least minimized or localized for the printing of a particular color can be determined. Following the determination of that angle for each of the colors to be printed, the screens are each then provided with photosensitive emulsion, exposed to light, and washed. The silk-screens are then placed in another carrier at the same angle as before determined for the elimination or at least the minimization or localization of moire, this carrier being capable of being placed directly into the nest of a print head of a conventional silk-screen printing machine.

Abstract: Silk-screens of annular-shape are provided for the silk-screen printing of halftones on compact discs. The silk-screens are rotatably provided in a carrier so that the angle at which moire can be eliminated or at least minimized or localized for the printing of a particular color can be determined. Following the determination of that angle for each of the colors to be printed, the screens are each then provided with photosensitive emulsion, exposed to light, and washed. The silk-screens are then placed in another carrier at the same angle as before determined for the elimination or at least the minimalization or localization of moire, this carrier being capable of being placed directly into the nest of a print head of a conventional silk-screen printing machine.

Abstract: Silk-screens of annular-shape are provided for the silk-screen printing of halftones on compact discs. The silk-screens are rotatably provided in a carrier so that the angle at which molre can be eliminated or at least minimized or localized for the printing of a particular color can be determined. Following the determination of that angle for each of the colors to be printed, the screens are each then provided with photosensitive emulsion, exposed to light, and washed. The silk-screens are then placed in another carrier at the same angle as before determined for the elimination or at least the minimalization or localization of molre, this carrier being capable of being placed directly into the nest of a print head of a conventional silk-screen printing machine.

Abstract: Silk-screens of annular-shape are provided for the silk-screen printing of halftones on compact discs. The silk-screens are rotatably provided in a carrier so that the angle at which moire can be eliminated or at least minimized or localized for the printing of a particular color can be determined. Following the determination of that angle for each of the colors to be printed, the screens are each then provided with photosensitive emulsion, exposed to light, and washed. The silk-screens are then placed in another carrier at the same angle as before determined for the elimination or at least the mimimalization or localization of moire, this carrier being capable of being placed directly into the nest of a print head of a conventional silk-screen printing machine.

Abstract: An apparatus and process for the manufacture of silk-screens is provided for use in the printing of halftones, e.g. in a four color printing process. The angle at which the mesh of a silk-screen should be relative to the screen frame to eliminate or at least minimize or localize moire' is predetermined for each of the color film separations. This angle is then carried to stretching apparatus for the woven fabric from which the silk-screens are to be made. The stretching appararatus has a table that is provided with a plurality of rotatable members. A screen frame is placed on each of the rotatable members and the rotable member is rotated to the angle determined by the pre-registration apparatus. The fabric is stretched to the desired tension and the screen frames having been provided at the desired angles are adhered to the stretched fabric, resulting in the mesh in each silk-screen being at the correct angle with respect to the screen frame.